DNA (Cytosine-5-)-Methyltransferase 3 alpha Proteins (DNMT3A)

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Additionally we are shipping DNMT3A Antibodies (267) and DNMT3A Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DNMT3A 1788 Q9Y6K1
Rat DNMT3A DNMT3A 444984 Q1LZ53
DNMT3A 13435 O88508
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Top DNMT3A Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Bioactivity measured with Activity Assay Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$860.20
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Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$400.46
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DNMT3A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Top referenced DNMT3A Proteins

  1. Human DNMT3A Protein expressed in HEK-293 Cells - ABIN2719617 : Cree, Fredericks, Miller, Pearce, Filichev, Fee, Kennedy: DNA G-quadruplexes show strong interaction with DNA methyltransferases in vitro. in FEBS letters 2016 (PubMed)

More Proteins for DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) Interaction Partners

Pig (Porcine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that the expression levels of the 5 epigenetic modifying genes Dnmt1 (show DNMT1 Proteins), Dnmt3a, Hdac1 (show HDAC1 Proteins), Kdm3a (show KDM3A Proteins) and Uhrf1 (show UHRF1 Proteins) were higher in group pig in highland (TH) than in group Yorkshire in highland (YH).

Human DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Data show that DNA methyltransferase 3A (DNMT3A) mutation was significantly associated with adverse outcome in addition to conventional risk stratification.

  2. DNMT3A polymorphisms may be potential predictive markers for acute myelogenous leukemia patients' outcomes in China

  3. this study shows that DNMT3A mutations are present in a significant proportion of SF3B1mut patients with RARS (show RARS Proteins) and its presence has a clearly negative impact on outcomes, determining a higher RBC (show CACNA1C Proteins) transfusion dependency, higher risk of progression to AML (show RUNX1 Proteins), and lower OS.

  4. DNMT1 (show DNMT1 Proteins), DNMT3A, and DNMT3B (show DNMT3B Proteins) were overexpressed in 36.9, 26, and 23 % of the OSCC patients, respectively. DNMT1 (show DNMT1 Proteins) overexpression was significantly associated with the overall survival, p = 0.029, and relapse-free survival of OSCC patients, p = 0.003. Patients with DNMT1 (show DNMT1 Proteins) overexpression, as an independent prognostic factor, had a 2.385 times higher risk to relapse than those with lower expression. The DNMT1 (show DNMT1 Proteins) A201G gene polymorphi

  5. genetic variations in STX1B (show STX1B Proteins), DNMT3A and CYP1A1 (show CYP1A1 Proteins) have roles in influencing warfarin maintenance dose

  6. DNMT3A is a de novo DNA methyltransferase (show DNMT1 Proteins) that has recently gained relevance because of its frequent mutation in a large variety of immature and mature hematologic neoplasms. DNMT3A mutations are early events during cancer development and seem to confer poor prognosis to acute myeloid leukemia (show BCL11A Proteins) patients making this gene an attractive target for new therapies. [review]

  7. the present cohort study demonstrated that FLT3 (show FLT3 Proteins)-ITD and DNMT3A R882 double mutation predicts poor prognosis in Chinese AML (show RUNX1 Proteins) patients receiving chemotherapy or allo-HSCT treatment.

  8. propose a model of the DNMT3A PWWP domain-H3K36me3 complex and build a model of DNMT3A (PWWP-ADD-CD) in a nucleosomal context

  9. Variability in placental telomere length is associated with alterations in DNAm at TERT (show TERT Proteins), DNMT1 (show DNMT1 Proteins), and DNMT3a.

  10. Dnmt1 (show DNMT1 Proteins) and Dnmt3a are critical regulators for epigenetic silencing of endothelial cell marker genes.

Horse (Equine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Among 18 genotypes analyzed, we were unable to record any significant differences in 5-methyl-2'-deoxycytidine levels, which suggested that age-related changes in global DNA methylation (show HELLS Proteins) content are rather a function of time, and not a genetic component.

Cow (Bovine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. The effect of p53 (show TP53 Proteins) expression on the development of cloned embryos, and its interaction with HDAC1 (show HDAC1 Proteins) and DNMT3A are reported.

  2. The expression levels of DNMT3a and DNMT3b (show DNMT3B Proteins) were associated with several beef quality traits.

Mouse (Murine) DNA (Cytosine-5-)-Methyltransferase 3 alpha (DNMT3A) interaction partners

  1. Deletion of DNMT3a in postnatal forebrain neurons does no alter affective behavior.

  2. Altogether, the authors demonstrate that Dnmt3a and Dnmt3b (show DNMT3B Proteins) protect the epidermis from tumorigenesis and that squamous carcinomas are sensitive to inhibition of PPAR-gamma (show PPARG Proteins).

  3. Upon lysolecithin injection in the spinal cord of transgenic mice, study detected defective oligodendrocyte progenitor cells differentiation and inefficient remyelination in the DNA methyltransferase 3a null and DNA methyltransferase 1/DNA methyltransferase (show DNMT1 Proteins) 3a null mice.

  4. This is attributed in part to ineffective repression of Tcf1 (show HNF1A Proteins) expression in knockout T cells, as DNMT3a localizes to the Tcf7 (show TCF7 Proteins) promoter and catalyzes its de novo methylation in early effector WT CD8 (show CD8A Proteins)(+) T cells. These data identify DNMT3a as a crucial regulator of CD8 (show CD8A Proteins)(+) early effector cell differentiation and effector versus memory fate decisions.

  5. Compared the activity of individual DNMT3A isoforms in embryonic stem and neuronal progenitor cells and report that these isoforms differ in their genomic binding and DNA methylation (show HELLS Proteins) activity at regulatory sites. We identify that the longer isoform DNMT3A1 preferentially localizes to the methylated shores of bivalent CpG island promoters in a tissue-specific manner.

  6. Study shows that in the mouse brain during early life, the DNA methyltransferase (show DNMT1 Proteins) DNMT3A preferentially binds transiently to intergenic regions and across transcribed regions of lowly expressed genes and that this binding primarily determines the pattern of DNA methylation (show HELLS Proteins) at CA sequences in the adult brain.

  7. conditional inactivation of Dnmt3a in mouse hematopoietic cells leads to an accumulation of immature progenitors in the thymus, which are less apoptotic. These data demonstrate that Dnmt3a is required for normal T-cell development, and acts as a T-ALL tumor suppressor

  8. These data demonstrate that haploinsufficiency for Dnmt3a alters hematopoiesis and predisposes mice (and probably humans) to myeloid malignancies by a mechanism that is not yet clear.

  9. Loss of DNMT3A expression is associated with development of malignancy.

  10. confirm the transformation potential of DNMT3A(R882H) Tet2(-/-) progenitors and represent the first cooperative model in mice involving Tet2 inactivation driving lymphoid malignancies

DNMT3A Protein Profile

Protein Summary

CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with DNMT3A

  • DNA methyltransferase 3 alpha (DNMT3A)
  • DNA methyltransferase 3 alpha (dnmt3a)
  • DNA methyltransferase 3 alpha (Dnmt3a)
  • DNA methyltransferase 3A (Dnmt3a)
  • DNMT3A protein
  • DNMT3A2 protein
  • M.HsaIIIA protein
  • MmuIIIA protein

Protein level used designations for DNMT3A

DNA (cytosine-5-)-methyltransferase 3 alpha , DNA cytosine methyltransferase 3 alpha , DNA (cytosine-5)-methyltransferase 3A , DNA methyl transferase alpha , DNA methyltransferase 3A , DNA MTase HsaIIIA , DNA cytosine methyltransferase 3A2 , DNA-methyltransferase 3a , DNA MTase MmuIIIA , DNA methyltransferase MmuIIIA

GENE ID SPECIES
482996 Canis lupus familiaris
694822 Macaca mulatta
739139 Pan troglodytes
100037301 Sus scrofa
100030681 Monodelphis domestica
100344715 Oryctolagus cuniculus
100500776 Ovis aries
100594618 Nomascus leucogenys
100529107 Anolis carolinensis
1788 Homo sapiens
421991 Gallus gallus
100510798 Felis catus
100055881 Equus caballus
359716 Bos taurus
444984 Rattus norvegicus
13435 Mus musculus
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