anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Antibodies

DRAM1 is regulated as part of the p53 tumor suppressor pathway. Additionally we are shipping DNA-Damage Regulated Autophagy Modulator 1 Kits (7) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DRAM1 55332 Q8N682
DRAM1 71712 Q9DC58
DRAM1 679937  
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Top anti-DNA-Damage Regulated Autophagy Modulator 1 Antibodies at antibodies-online.com

Showing 10 out of 55 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-DRAM Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: A549 cell lysate WB Suggested Anti-DRAM  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control: A549 cell lysate  DRAM1 is supported by BioGPS gene expression data to be expressed in A549 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Dram1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Small Intestine 100 μL 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB 100 μg 2 to 3 Days
$325.00
Details
Human Rabbit Un-conjugated IHC, WB WB on PC12 cell lysate using Rabbit antibody to DRAM (Damage-regulated autophagy modulator): whole serum (ABIN350296) at 1 : 300 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band. IHC-P on human stomach-4 150 μL 7 to 8 Days
$454.67
Details
Dog Rabbit Un-conjugated WB 100 μg 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated EIA, IHC (fro), IHC (p), WB 50 μg 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated IHC, ELISA, WB   100 μg 15 to 19 Days
$527.03
Details

Top referenced anti-DNA-Damage Regulated Autophagy Modulator 1 Antibodies

  1. Human Polyclonal DRAM1 Primary Antibody for IHC (p), WB - ABIN541581 : Chen, Chen, Liu, Wang, Pan, Teng: TW01001, a novel piperazinedione compound, induces mitotic arrest and autophagy in non-small cell lung cancer A549 cells. in Cancer letters 2013 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal DRAM1 Primary Antibody for IHC (p), WB - ABIN2473364 : Watanabe, Abe, Tanaka, Takeuchi, Yasuura, Hikosaka, Suenaga, Hosokawa, Iwasa, Yamori: [Closure of ventricular septal defect of interrupted aortic arch with left ventricular outflow obstruction]. in Kyobu geka. The Japanese journal of thoracic surgery 1992 (PubMed)
    Show all 3 Pubmed References

  3. Human Polyclonal DRAM1 Primary Antibody for IHC, ELISA - ABIN1002228 : Crighton, Wilkinson, OPrey, Syed, Smith, Harrison, Gasco, Garrone, Crook, Ryan: DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. in Cell 2006 (PubMed)
    Show all 3 Pubmed References

  4. Human Polyclonal DRAM1 Primary Antibody for IHC, ELISA - ABIN1002229 : Gozuacik, Kimchi: Autophagy as a cell death and tumor suppressor mechanism. in Oncogene 2004 (PubMed)
    Show all 3 Pubmed References

More Antibodies against DNA-Damage Regulated Autophagy Modulator 1 Interaction Partners

Human DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) interaction partners

  1. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA) and autophagy (DRAM) gene occurred, modifying the ADR-induced cancer cell death in HG both in vitro and in vivo.

  2. Overexpression of full-length AIFM1 suppresses proliferation and induces apoptosis of HepG2 and Hep3B cells. Caspase 3 and DRAM are involved in full-length AIFM1-induced apoptosis in HepG2 and Hep3B cells.

  3. DRAM1 regulates apoptosis by inhibiting BAX degradation.

  4. DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide.

  5. Suggest that promoting DRAM-mediated autophagy together with PI3K/AKT inhibition might be more effective for autophagy-based therapy in hepatoma.

  6. DRAM is an important gene for the enhancement of p53-dependent apoptosis.

  7. DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes.

  8. DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

  9. DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV.

  10. these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells.

  11. Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression.

  12. p73-regulated DRAM-1 is functionally involved in neutrophil differentiation of acute promyelocytic leukemia cells.

  13. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.

  14. Overexpression of DRAM induces VRK1 downregulation and the opposite effect was observed by its knockdown.

  15. Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death.

  16. DRAM links autophagy to p53 and programmed cell death.

  17. identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types.

  18. DRAM is activated by p53 which is required for the ability of p53 to induce autophagy and is also critical for the ability of p53 to induce programmed cell death.

  19. c-Jun NH2-terminal kinase as a novel mediator of DRAM protein regulation in Ewing sarcoma cells

Mouse (Murine) DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) interaction partners

  1. DRAM1 knockdown aggravates OGD/R-induced cell injury.

  2. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.

DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Antigen Profile

Protein Summary

This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4.

Gene names and symbols associated with DRAM1

  • DNA damage regulated autophagy modulator 1 (DRAM1) antibody
  • DNA-damage regulated autophagy modulator 1 (Dram1) antibody
  • DNA damage regulated autophagy modulator 1 L homeolog (dram1.L) antibody
  • 1200002N14Rik antibody
  • dram antibody
  • DRAM1 antibody

Protein level used designations for DRAM1

DNA-damage regulated autophagy modulator 1 , DNA damage-regulated autophagy modulator protein 1 , damage-regulated autophagy modulator , Damage-regulated autophagy modulator

GENE ID SPECIES
418095 Gallus gallus
612179 Canis lupus familiaris
100462750 Sus scrofa
55332 Homo sapiens
71712 Mus musculus
679937 Rattus norvegicus
533992 Bos taurus
431986 Xenopus laevis
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