anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Antibodies

Human DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) interaction partners

1. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53 (show TP53 Antibodies)-dependent apoptosis (PUMA (show BBC3 Antibodies)) and autophagy (DRAM) gene occurred, modifying the ADR (show AKR1B1 Antibodies)-induced cancer cell death in HG both in vitro and in vivo.

2. Overexpression of full-length AIFM1 (show AIFM1 Antibodies) suppresses proliferation and induces apoptosis of HepG2 and Hep3B cells. Caspase 3 (show CASP3 Antibodies) and DRAM are involved in full-length AIFM1 (show AIFM1 Antibodies)-induced apoptosis in HepG2 and Hep3B cells.

3. DRAM1 regulates apoptosis by inhibiting BAX (show BAX Antibodies) degradation.

4. DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide.

5. Suggest that promoting DRAM-mediated autophagy together with PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) inhibition might be more effective for autophagy-based therapy in hepatoma.

6. DRAM is an important gene for the enhancement of p53 (show TP53 Antibodies)-dependent apoptosis.

7. DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes.

8. DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

9. DRAM triggers lysosomal membrane permeabilization and cell death in CD4 (show CD4 Antibodies)(+) T cells infected with HIV.

10. these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells.

Mouse (Murine) DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) interaction partners

1. DRAM1 knockdown aggravates OGD (show FGFR1 Antibodies)/R-induced cell injury.

2. DRAM-1 encodes not just one mRNA, but a series of p53 (show TP53 Antibodies)-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.