anti-DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) Antibodies

Human DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) interaction partners

1. Our results indicated that DRAM1 protected cardiomyocytes from ischemia stress-induced autophagy flux obstacle and uncovered a novel DRAM1-Atg7-Atg12/Atg5 autophagy flux regulation pathway under conditions of myocardial ischemic stress.

2. these results identify that the class I PI3K-Akt-rpS6 pathway is regulated by DRAM1 and may provide new insight into the potential role of DRAM1 in human cancers.

3. Altogether, these findings suggest that in normal/high glucose condition a mutual unbalance between p53-dependent apoptosis (PUMA) and autophagy (DRAM) gene occurred, modifying the ADR-induced cancer cell death in HG both in vitro and in vivo.

4. Overexpression of full-length AIFM1 suppresses proliferation and induces apoptosis of HepG2 and Hep3B cells. Caspase 3 and DRAM are involved in full-length AIFM1-induced apoptosis in HepG2 and Hep3B cells.

5. DRAM1 regulates apoptosis by inhibiting BAX degradation.

6. DRAM1 mediates autophagic defense against a broader range of intracellular pathogens, since DRAM1 expression was also induced by the common bacterial endotoxin lipopolysaccharide.

7. Suggest that promoting DRAM-mediated autophagy together with PI3K/AKT inhibition might be more effective for autophagy-based therapy in hepatoma.

8. DRAM is an important gene for the enhancement of p53-dependent apoptosis.

9. DRAM1 affects autophagy through lysosomal acidification, fusion of lysosomes with autophagosomes and clearance of autophagosomes.

10. DRAM gene expression is down regulated by oxidative stress through the mediation of reactive oxygen species

11. DRAM triggers lysosomal membrane permeabilization and cell death in CD4(+) T cells infected with HIV.

12. these findings shed new light on the role of autophagy in GBM and reveal a novel function of the autophagy regulators DRAM1 and p62 in control of migration/invasion in cancer stem cells.

13. Overexpression of miR-199a-5p inhibits DRAM1 and Beclin1 expression.

14. p73-regulated DRAM-1 is functionally involved in neutrophil differentiation of acute promyelocytic leukemia cells.

15. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.

16. Overexpression of DRAM induces VRK1 downregulation and the opposite effect was observed by its knockdown.

17. Collectively therefore, these studies not only report a stress-induced regulator of autophagy but also highlight the relationship of DRAM and autophagy to p53 function and damage-induced programmed cell death.

18. DRAM links autophagy to p53 and programmed cell death.

19. identified FLJ11259/DRAM as a p53-inducible member of a novel family of transmembrane proteins. FLJ11259/DRAM may be an important modulator of p53 responses in diverse tumor types.

20. DRAM is activated by p53 which is required for the ability of p53 to induce autophagy and is also critical for the ability of p53 to induce programmed cell death.

Mouse (Murine) DNA-Damage Regulated Autophagy Modulator 1 (DRAM1) interaction partners

1. DRAM1 knockdown aggravates OGD/R-induced cell injury.

2. DRAM-1 encodes not just one mRNA, but a series of p53-inducible splice variants which are expressed at varying levels in multiple human and mouse cell lines.