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DRAM antibody (N-Term)

DRAM1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN6990614
  • Target See all DRAM (DRAM1) Antibodies
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Binding Specificity
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 30-80, N-Term
    Reactivity
    • 17
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Mouse, Rat
    Host
    • 17
    Rabbit
    Clonality
    • 17
    Polyclonal
    Conjugate
    • 13
    • 2
    • 1
    • 1
    This DRAM antibody is un-conjugated
    Application
    • 12
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Purification
    DRAM Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-DRAM antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human DRAM. The immunogen is located within amino acids 30-80 of DRAM.
    Isotype
    IgG
    Top Product
    Discover our top product DRAM1 Primary Antibody
  • Application Notes
    WB: 1-2 μ,g/mL, IF: 20 μ,g/mL, IHC: 2-2.5 μ,g/mL.

    Antibody validated: Western Blot in human mouse and rat samples, Immunofluorescence and Immunohistochemistry in human and mouse samples. All other applications and species not yet tested.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    DRAM Antibody is supplied in PBS containing 0.02 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,4 °C
    Storage Comment
    DRAM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Alternative Name
    DRAM (DRAM1 Products)
    Synonyms
    DRAM1 antibody, DRAM antibody, 1200002N14Rik antibody, Dram antibody, dram antibody, DNA damage regulated autophagy modulator 1 antibody, DNA-damage regulated autophagy modulator 1 antibody, DNA damage regulated autophagy modulator 1 L homeolog antibody, DRAM1 antibody, Dram1 antibody, dram1.L antibody
    Background
    DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
    Molecular Weight
    Predicted: 14kD, 26kD

    Observed: 14 kD, 26kD kDa
    Gene ID
    55332
    UniProt
    Q8N682
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