DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) ELISA Kits

The protein encoded by DOT1L is a histone methyltransferase that methylates lysine-79 of histone H3. Additionally we are shipping DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Antibodies (82) and DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
DOT1L 84444 Q8TEK3
Anti-Rat DOT1L DOT1L 362831  
DOT1L 208266  
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Top DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) ELISA Kits at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.058 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$810.53
Details
Mouse 0.063 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
$833.68
Details
Human < 0.058 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$867.02
Details
Mouse < 0.063 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$874.13
Details

More ELISA Kits for DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) Interaction Partners

Human DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. human mammary epithelial cells reprogramming is dependent on gene silencing by the DNA methyltransferase (show DNMT1 ELISA Kits) DNMT3A (show DNMT3A ELISA Kits) and loss of histone transcriptional marks following downregulation of the methyltransferase DOT1L.

  2. this study shows that Dot1l expression predicts adverse postoperative prognosis of patients with clear-cell renal cell carcinoma

  3. facilitates DNA damage repair; plays a protective role in ultraviolet radiation-induced melanomagenesis

  4. DOT1L cooperates with transcription factor ETS-1 (show ETS1 ELISA Kits) to stimulate the expression of VEGFR2 (show KDR ELISA Kits), thereby activating ERK1/2 (show MAPK1/3 ELISA Kits) and AKT (show AKT1 ELISA Kits) signaling pathways and promoting angiogenesis.

  5. findings demonstrate that DOT1L over-expression has important clinical significance in ovarian cancer and also clarify that it drives cell cycle progression through transcriptional regulation of CDK6 (show CDK6 ELISA Kits) and CCND3 (show CCND3 ELISA Kits) through H3K79 methylation

  6. MLL-AF4 spreading gene expression is downregulated by inhibitors of the H3K79 methyltransferase DOT1L.

  7. our results identify DOT1L as a novel cofactor in N-Myc-mediated transcriptional activation of target genes and neuroblastoma oncogenesis. Furthermore, they characterize DOT1L inhibitors as novel anticancer agents against MYCN-amplified neuroblastoma.

  8. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  9. this indicates that DOT1L function, like MLL, does not completely rely on its methyltransferase activity. Nevertheless, the small molecule DOT1L inhibition is sufficient to block the proliferation of MLL fusion-induced leukemia cells of murine and human origin

  10. DOT1L may play a critical role in DNMT3A (show DNMT3A ELISA Kits)-mutant leukemia.

Mouse (Murine) DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) interaction partners

  1. In the absence of DOT1L, ultraviolet radiation (UVR)-induced DNA damage is inefficiently repaired, so that DOT1L loss promotes melanoma development after exposure to UVR.

  2. We will highlight the structural basis of chromatin targeting of DOT1L through its cofactors and the role of DOT1L in repelling transcription repressive complexes during leukemia development.

  3. These results reveal a cooperative transcriptional activation mechanism of AEP and DOT1L and suggest a molecular rationale for the simultaneous inhibition of the MLL fusion-AF4 complex and DOT1L for more effective treatment of MLL-rearranged leukemia.

  4. DOT1L may play a critical role in DNMT3A (show DNMT3A ELISA Kits)-mutant leukemia.

  5. DOT1L, via dimethylated histone H3 (show HIST3H3 ELISA Kits) K79, facilitates histone H4 acetylation, which in turn regulates the binding of BRD4 (show BRD4 ELISA Kits) to chromatin in acute lymphoblastic leukemia.

  6. Dot1l is a new epigenetic regulator of principal cells and intercalated cell differentiation and Atp6v1b1 is a new transcriptional target of Dot1l.

  7. results demonstrate that histone methylation, and in particular DOT1L-mediated H3K79me2 modification, drives cardiomyogenesis through the definition of a specific transcriptional landscape

  8. Interference with DOT1L activity resulted in transcriptional activation of Atf4 (show ATF4 ELISA Kits) and Ddit3 (show DDIT3 ELISA Kits) accompanied by decreased levels of H3K79 dimethylation.

  9. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia (show BCL11A ELISA Kits).

  10. DOT1L has a role in inhibiting SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia

DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) Antigen Profile

Antigen Summary

The protein encoded by this gene is a histone methyltransferase that methylates lysine-79 of histone H3. It is inactive against free core histones, but shows significant histone methyltransferase activity against nucleosomes.

Gene names and symbols associated with DOT1L

  • histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC100116648) antibody
  • DOT1 like histone lysine methyltransferase (DOT1L) antibody
  • histone methyltransferase (DOT1) antibody
  • DOT1 like histone lysine methyltransferase (Dot1l) antibody
  • DOT1-like, histone H3 methyltransferase (S. cerevisiae) (Dot1l) antibody
  • A630076O07 antibody
  • AW907654 antibody
  • Dot1 antibody
  • DOT1L antibody
  • KMT4 antibody
  • mDot1 antibody
  • NV11307 antibody

Protein level used designations for DOT1L

histone-lysine N-methyltransferase, H3 lysine-79 specific , DOT1-like, histone H3 methyltransferase (S. cerevisiae) , histone-lysine N-methyltransferase, H3 lysine-79 specific-like , possible nucleosomal histone methylase , DOT1-like protein , DOT1-like, histone H3 methyltransferase , H3-K79-HMTase , histone H3-K79 methyltransferase , histone methyltransferase DOT1L , lysine N-methyltransferase 4 , DOT1-like histone H3 methyltransferase , histone H3 methyltransferase DOT1

GENE ID SPECIES
100116648 Nasonia vitripennis
420078 Gallus gallus
100068506 Equus caballus
485073 Canis lupus familiaris
710033 Macaca mulatta
100464435 Ailuropoda melanoleuca
100619840 Monodelphis domestica
3642236 Candida albicans SC5314
84444 Homo sapiens
362831 Rattus norvegicus
208266 Mus musculus
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