anti-Deoxyuridine Triphosphatase Antibodies
DUT encodes an essential enzyme of nucleotide metabolism.
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anti-Deoxyuridine Triphosphatase (DUT) (AA 68-164) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (C-Term) antibody Primary Antibody
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anti-Deoxyuridine Triphosphatase (DUT) (Internal Region) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (C-Term) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (N-Term) antibody Primary Antibody
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anti-Deoxyuridine Triphosphatase (DUT) (AA 170-198), (C-Term) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (N-Term) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (AA 212-229), (C-Term) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (AA 1-252) antibody Primary Antibody
anti-Deoxyuridine Triphosphatase (DUT) (C-Term) antibody Primary Antibody
Deoxyuridine Triphosphatase (DUT) Antigen Profile
Protein Summary
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
Gene names and symbols associated with DUT
- deoxyuridine triphosphatase (DUT) antibody
- Deoxyuridine triphosphatase (dUTPase) antibody
- deoxyuridine triphosphatase (P18) antibody
- dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 (AlHV1gp51) antibody
- deoxyuridine triphosphatase (UL50) antibody
- deoxyuridine triphosphatase (HVT058) antibody
- involved in nucleotide metabolism (UL50) antibody
- deoxyuridine triphosphatase (ORF9) antibody
- deoxyuridine triphosphatase (ORF8) antibody
- tegument protein (U45) antibody
- dUTPase (GAMMAHV.ORF54) antibody
- deoxyuridine triphosphatase (Tc00.1047053509151.130) antibody
- deoxyuridine triphosphatase (Tc00.1047053508175.160) antibody
- deoxyuridine triphosphatase (Tb927.7.5160) antibody
- deoxyuridine triphosphatase L homeolog (dut.L) antibody
- deoxyuridine triphosphatase (Dut) antibody
- 5031412I06Rik antibody
- 5133400F09Rik antibody
- anon-SAGE:Wang-077 antibody
- BcDNA:LD08534 antibody
- CG4584 antibody
- D2Bwg0749e antibody
- Dmel\\CG4584 antibody
- Dutp antibody
- dutpase antibody
- LD08534 antibody
- PIP4 antibody
- Tb07.27E10.390 antibody
- UTPase antibody
Protein level used designations for DUT
dUTP pyrophosphatase , CG4584-PA , CG4584-PB , CG4584-PC , CG4584-PD , anon-SAGE:Wang-077 , dUTPase-PA , dUTPase-PB , dUTPase-PC , dUTPase-PD , deoxyuridine triphosphatase , deoxyuridine 5'-triphosphate nucleotidohydrolase , deoxyuridine triphosphatase, dUTPase, P18 , dUTP nucleotidohydrolase , deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial , PPAR-interacting protein 4 , dUTPase
| GENE ID | SPECIES |
|---|---|
| 714401 | Macaca mulatta |
| 34529 | Drosophila melanogaster |
| 544274 | Solanum lycopersicum |
| 911778 | Alcelaphine herpesvirus 1 |
| 911900 | Gallid herpesvirus 3 |
| 918521 | Meleagrid herpesvirus 1 |
| 1487339 | Human herpesvirus 2 |
| 1487399 | Bovine herpesvirus 1 |
| 1487647 | Equid herpesvirus 4 |
| 1487671 | Human herpesvirus 3 |
| 1487924 | Human herpesvirus 6A |
| 1497169 | Murid herpesvirus 4 |
| 2703421 | Human herpesvirus 1 |
| 3545542 | Trypanosoma cruzi strain CL Brener |
| 3553795 | Trypanosoma cruzi strain CL Brener |
| 3658718 | Trypanosoma brucei brucei strain 927/4 GUTat10.1 |
| 100037200 | Xenopus laevis |
| 1854 | Homo sapiens |
| 609526 | Canis lupus familiaris |
| 110074 | Mus musculus |
| 497778 | Rattus norvegicus |
| 507945 | Bos taurus |
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