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anti-Deoxyuridine Triphosphatase (DUT) Antibodies

DUT encodes an essential enzyme of nucleotide metabolism. Additionally we are shipping Deoxyuridine Triphosphatase Proteins (88) and Deoxyuridine Triphosphatase Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DUT 1854 P33316
DUT 110074  
DUT 497778 P70583
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Top anti-Deoxyuridine Triphosphatase Antibodies at antibodies-online.com

Showing 10 out of 124 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, WB WB Suggested Anti-DUT Antibody Titration: 1 ug/ml Positive Control: Fetal Small Intestine cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated IHC, WB Human Heart 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated ELISA, IHC, WB ABIN5539501 (0.1µg/ml) staining of HEK293 (A) and HeLa (B) lysates (35µg protein in RIPA buffer). Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: dUTPase Antibody [NBP2-33277] - liver cancer Immunohistochemistry-Paraffin: dUTPase Antibody [NBP2-33277] - liver 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated ELISA, IF, IHC, WB Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (36.3 KDa) . Dilution: 1:500~1000 100 μg Log in to see 8 to 11 Days
$527.50
Details
Bat Rabbit Un-conjugated IHC, IHC (p), WB 100 μg Log in to see 11 to 14 Days
$493.17
Details
Human Rabbit Un-conjugated IHC (p), WB DUT Antibody (C-term) (ABIN658124) western blot analysis in human normal Uterus cell line lysates (35 µg/lane). This demonstrates the DUT antibody detected the DUT protein (arrow). Anti-DUT Antibody (C-term)at 1:1000 dilution + SW620 whole cell lysates Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution Predicted band size : 26. 5 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Chicken Un-conjugated IHC, IHC (p), WB Human Kidney (formalin-fixed, paraffin-embedded) stained with DUT antibody ABIN290266 at 5 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Pancreas (formalin-fixed, paraffin-embedded) stained with DUT antibody ABIN290266 at 5 ug/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 11 to 14 Days
$550.00
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-DUT antibody, Western blotting All lanes: Anti DUT () at 0.5ug/ml Lane 1: HELA Whole Cell Lysate at 40ug Lane 2: SMMC Whole Cell Lysate at 40ug Predicted bind size: 27KD Observed bind size: 27KD Anti-DUT antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Rabbit Un-conjugated IHC (p), IP, WB Immunohistochemical analysis of paraffin embedded rat tissue sections (cardiac muscle), staining DUTPase in cytoplasm, DAB chromogenic reaction 0.1 mg Log in to see 6 to 8 Days
$456.50
Details

Top referenced anti-Deoxyuridine Triphosphatase Antibodies

  1. Human Monoclonal DUT Primary Antibody for IF, IHC (p) - ABIN560672 : Kiyonari, Iimori, Matsuoka, Watanabe, Morikawa-Ichinose, Miura, Niimi, Saeki, Tokunaga, Oki, Morita, Kadomatsu, Maehara, Kitao: The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis. in Molecular cancer therapeutics 2015 (PubMed)

  2. Cow (Bovine) Polyclonal DUT Primary Antibody for IHC, WB - ABIN2782436 : Studebaker, Lafuse, Kloesel, Williams: Modulation of human dUTPase using small interfering RNA. in Biochemical and biophysical research communications 2005 (PubMed)

  3. Human Polyclonal DUT Primary Antibody for IHC, WB - ABIN2782437 : Tóth, Varga, Kovács, Málnási-Csizmadia, Vértessy: Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against Deoxyuridine Triphosphatase Interaction Partners

Fruit Fly (Drosophila melanogaster) Deoxyuridine Triphosphatase (DUT) interaction partners

  1. revealed the importance of the PAA(10-12) tripeptide and the ID(17-18) dipeptide, as well as the role of the PAAK(10-13) segment in nuclear localization of dUTPase.

  2. there is a conformational shift essential for catalytic competence in the 60-kDa Drosophila melanogaster dUTPase trimer

  3. kinetic characterization, folding, and crystallographic studies of dUTPase

  4. dUTPase is developmentally regulated in Drosophila melanogaster

  5. dUTPase, a recently described eukaryotic model, has a similar affinity of binding towards alpha,beta-imino-dUTP as compared to the prokaryotic E. coli enzyme

  6. dUTPase localization character showed strict timing to the nuclear cleavage phases and explained how its isoforms can be present within the nuclear microenvironment, although at different stages of cell cycle.

Human Deoxyuridine Triphosphatase (DUT) interaction partners

  1. A single homozygous missense mutation (chr15.hg19:g.48,626,619A>G) located in the dUTPase (DUT) gene was associated with a syndrome of bone marrow failure and diabetes.

  2. Comparison of the cellular distribution of wild-type dUTPase with those of hyperphosphorylation- and hypophosphorylation-mimicking mutants suggests that phosphorylation at Ser11 leads to the exclusion of dUTPase from the nucleus.

  3. EBV-encoded dUTPase may act as an intercellular signaling molecule capable of modulating the cellular microenvironment

  4. Data sugget that inhibition of dUTPase is a mechanism-based therapeutic approach to significantly enhance the efficacy of thymidylate synthase (TS)-targeted chemotherapeutic agents.

  5. Repression of dUTPase induced specific expression level increments for thymidylate kinase and thymidine kinase, and also an increased sensitization to 5-fluoro-2'-deoxyuridine and 5-fluoro-uracil.

  6. High dUTP pyrophosphatase is associated with recurrence in colorectal cancer patients undergoing 5-fluorouracil adjuvant chemotherapy

  7. nuclear dUTPase may be a good biomarker for predicting prognosis in HCC patients after surgical resection

  8. significant differences between the human and Plasmodium dUTPases

  9. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

  10. Nuclear dUTPase may contain a complex nuclear localization signal that is located throughout the entire protein.

  11. dUTPase staining provides a useful measure of cell proliferation distinct from that offered by Ki-67 labeling. It proved particularly useful for the evaluation of diffuse astrocytomas.

  12. kinetic model of the human dUTPase catalytic cycle

  13. determined the crystal structure of the enzyme:alpha,beta-imino-dUTP

  14. Establishment of a direct role for both mutant and wild-type forms of p53 in modulating dUTPase promoter activity.

  15. hinge proline destabilize human and Escherichia coli dUTPases without preventing trimeric organization

Mouse (Murine) Deoxyuridine Triphosphatase (DUT) interaction partners

  1. Novel gain of function activity of p53 mutants: activation of the dUTPase gene expression leading to resistance to 5-fluorouracil.

Deoxyuridine Triphosphatase (DUT) Antigen Profile

Protein Summary

This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Gene names and symbols associated with DUT

  • deoxyuridine triphosphatase (DUT) antibody
  • Deoxyuridine triphosphatase (dUTPase) antibody
  • deoxyuridine triphosphatase (P18) antibody
  • dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 (AlHV1gp51) antibody
  • deoxyuridine triphosphatase (UL50) antibody
  • deoxyuridine triphosphatase (HVT058) antibody
  • involved in nucleotide metabolism (UL50) antibody
  • deoxyuridine triphosphatase (ORF9) antibody
  • deoxyuridine triphosphatase (ORF8) antibody
  • tegument protein (U45) antibody
  • dUTPase (GAMMAHV.ORF54) antibody
  • deoxyuridine triphosphatase (Tc00.1047053509151.130) antibody
  • deoxyuridine triphosphatase (Tc00.1047053508175.160) antibody
  • deoxyuridine triphosphatase (Tb927.7.5160) antibody
  • deoxyuridine triphosphatase L homeolog (dut.L) antibody
  • deoxyuridine triphosphatase (Dut) antibody
  • 5031412I06Rik antibody
  • 5133400F09Rik antibody
  • anon-SAGE:Wang-077 antibody
  • BcDNA:LD08534 antibody
  • CG4584 antibody
  • D2Bwg0749e antibody
  • Dmel\\CG4584 antibody
  • Dutp antibody
  • dutpase antibody
  • LD08534 antibody
  • PIP4 antibody
  • Tb07.27E10.390 antibody
  • UTPase antibody

Protein level used designations for DUT

dUTP pyrophosphatase , CG4584-PA , CG4584-PB , CG4584-PC , CG4584-PD , anon-SAGE:Wang-077 , dUTPase-PA , dUTPase-PB , dUTPase-PC , dUTPase-PD , deoxyuridine triphosphatase , deoxyuridine 5'-triphosphate nucleotidohydrolase , deoxyuridine triphosphatase, dUTPase, P18 , dUTP nucleotidohydrolase , deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial , PPAR-interacting protein 4 , dUTPase

GENE ID SPECIES
714401 Macaca mulatta
34529 Drosophila melanogaster
544274 Solanum lycopersicum
911778 Alcelaphine herpesvirus 1
911900 Gallid herpesvirus 3
918521 Meleagrid herpesvirus 1
1487339 Human herpesvirus 2
1487399 Bovine herpesvirus 1
1487647 Equid herpesvirus 4
1487671 Human herpesvirus 3
1487924 Human herpesvirus 6A
1497169 Murid herpesvirus 4
2703421 Human herpesvirus 1
3545542 Trypanosoma cruzi strain CL Brener
3553795 Trypanosoma cruzi strain CL Brener
3658718 Trypanosoma brucei brucei strain 927/4 GUTat10.1
100037200 Xenopus laevis
1854 Homo sapiens
609526 Canis lupus familiaris
110074 Mus musculus
497778 Rattus norvegicus
507945 Bos taurus
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