anti-Desmocollin 2 (DSC2) Antibodies

The protein encoded by DSC2 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. Additionally we are shipping Desmocollin 2 Proteins (15) and Desmocollin 2 Kits (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DSC2 1824 Q02487
DSC2 13506 P55292
DSC2 291760  
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Top anti-Desmocollin 2 Antibodies at antibodies-online.com

Showing 10 out of 83 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB IHC-P Image Immunohistochemical analysis of paraffin-embedded OVCAR3 xenograft , using Desmocollin 2 , antibody at 1:500 dilution. WB Image Desmocollin 2 antibody [C1C2], Internal detects Desmocollin 2 protein by western blot analysis. Whole cell extracts (30 μg) was separated by 7.5 % SDS-PAGE, and blotted with Desmocollin 2 antibody [C1C2], Internal , diluted by 1:500 100 μL Log in to see 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Desmocollin-2 Antibody [NBP1-85710] - Immunohistochemical staining of human heart muscle shows strong membranous and cytoplasmic positivity in myocytes. Immunohistochemistry-Paraffin: Desmocollin-2 Antibody  - Staining of human esophagus shows strong membranous positivity in squamous epithelial cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Rabbit Un-conjugated IHC (p), IHC, WB Immunohistochemistry-Paraffin: Desmocollin-2 Antibody [NBP1-32961] - Paraffin-embedded OVCAR3 xenograft, using antibody at 1:500 dilution. Western Blot: Desmocollin-2 Antibody [NBP1-32961] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE, antibody diluted at 1:500. 100 μL Log in to see 8 to 11 Days
$516.98
Details
Human Rabbit Un-conjugated IHC (p), ELISA Immunochemical staining of human DSC2 in human esophagus with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to membrane of the squamous epithelium. Immunochemical staining of human DSC2 in human heart with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to intercalated disk. The left panel: tissue incubated with primary antibody; The ri 100 μg Log in to see 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Log in to see 13 to 16 Days
$350.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of extract of various cells, using DSC2 antibody. Western blot analysis of extracts of various cell lines, using DSC2 antibody (ABIN4903516) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Rat Rabbit Un-conjugated IHC (p), ELISA Rat DSC2 Immunohistochemistry(IHC) 7885 100 μg Log in to see 14 to 16 Days
$247.82
Details
Human Rabbit Un-conjugated IP, WB Immunoprecipitation of DSC2 transfected lysate using anti-DSC2 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with DSC2 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of DSC2 expression in transfected 293T cell line by DSC2 MaxPab polyclonal antibody.Lane 1: DSC2 transfected lysate(93.8 KDa).Lane 2: Non-transfected lysate. 100 μL Log in to see 11 to 12 Days
$350.67
Details
Human Mouse Un-conjugated WB Western Blot analysis of DSC2 expression in transfected 293T cell line by DSC2 MaxPab polyclonal antibody.Lane 1: DSC2 transfected lysate(93.17 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$364.00
Details

Top referenced anti-Desmocollin 2 Antibodies

  1. Human Monoclonal Desmocollin 2 Primary Antibody for FACS, IF - ABIN5576844 : Buxton, Cowin, Franke, Garrod, Green, King, Koch, Magee, Rees, Stanley: Nomenclature of the desmosomal cadherins. in The Journal of cell biology 1993 (PubMed)

  2. Human Polyclonal Desmocollin 2 Primary Antibody for IHC, IHC (p) - ABIN4305005 : Gehmlich, Syrris, Peskett, Evans, Ehler, Asimaki, Anastasakis, Tsatsopoulou, Vouliotis, Stefanadis, Saffitz, Protonotarios, McKenna: Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations. in Cardiovascular research 2011 (PubMed)

More Antibodies against Desmocollin 2 Interaction Partners

Human Desmocollin 2 (DSC2) interaction partners

  1. Desmocollin-2 genetic variant contributes to Arrhythmogenic Right Ventricular Cardiomyopathy

  2. PKP3 overexpression increases the stability of other desmosomal proteins independently of the increase in DSC2 levels and regulates desmosome formation and stability by a multimodal mechanism affecting transcription, protein stability and cell border localization of desmosomal proteins.

  3. The cardiac specific DSC2 transgenic mice develop severe biventricular cardiomyopathy.

  4. A novel missense mutation (c.1090 G > A/p.V364 M) of DSC2 was identified in a Chinese family with arrhythmogenic right ventricular cardiomyopathy.

  5. Data suggest juxtamembrane regions/domains of desmocollin-2 (DSC2), plakophilin 2 (PKP2), and plakophilin 3 (PKP3) are involved in desmosome formation in epithelial cells; DSC2 participates in desmosome formation in absence of desmoglein 2 (DSG2).

  6. Oxidized low-density lipoprotein attenuated desmoglein 1 and desmocollin 2 expression in human umbilical vein endothelial cells.

  7. DSC2 promoter methylation is associated with Breast Cancer.

  8. Homozygous founder mutation in DSC2 gene identified among Italian arrhythmogenic cardiomyopathy probands, providing evidence of the occurrence of recessive DSC2 mutations presenting with biventricular forms of the disease.

  9. Desmocollin-2 mutations are described for dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy, as well. Desmocollin-2 mutation was described in a case of arrhythmogenic biventricular cardiomyopathy

  10. a novel Nrf2-miR-29-Dsc2 axis controls desmosome function and cutaneous homeostasis

  11. ECG reliably identifies homozygous p.Gln554X desmocollin-2 carriers and may be useful as an initial step in the screening of high-risk Hutterites.

  12. DSC2 may be involved in the regulation of the invasive behavior of cells by a mechanism that controls cellcell attachment and cytoskeleton rearrangement

  13. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling.

  14. Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases.

  15. Case of arrhythmogenic right ventricular cardiomyopathy with a previously unreported desmocollin-2 mutation (c.712_714delGAT). This genetic variant displays autosomal recessive inheritance without the cutaneous manifestations.

  16. Reduced cardiac desmoglein-2 and desmocollin-2 levels appear to be specifically associated with Arrhythmogenic right ventricular Dysplasia/cardiomyopathy, independent of underlying mutations.

  17. A homozygous truncation mutation, c.1660C>T (p.Q554X) in desmocollin-2 (DSC2) was idnetified in affected individuals and determined a carrier frequency of this mutation of 9.4% among 1535 Schmiedeleut Hutterites.

  18. results suggest that abnormal activation of beta-catenin contributes to adenomyosis development through the induction of epithelial-mesenchymal transition

  19. High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas.

  20. DSC2 is a useful immunohistochemical marker for separation of Urothelial carcinoma with squamous differentiation from pure Urothelial carcinoma

Mouse (Murine) Desmocollin 2 (DSC2) interaction partners

  1. these results demonstrate that Dsg2, but not desmocollin 2 is required for the integrity of the intestinal epithelial barrier in vivo

  2. Downregulation of DSC2 is associated with arrhythmogenic cardiomyopathy.

  3. Cardiac specific overexpression of desmocollin-2 induces necrosis, acute inflammation and patchy cardiac fibrotic remodeling leading to fulminant biventricular cardiomyopathy.

  4. Data demonstrate that partner desmosomal cadherins Dsg2 and Dsc2 play opposing roles in controlling colonic carcinoma cell proliferation through differential effects on EGFR signaling.

  5. plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1) differentially regulates the proximal promoters of Dsc2 and Dsc3

Desmocollin 2 (DSC2) Antigen Profile

Protein Summary

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia-11. Alternative splicing results in two transcript variants encoding distinct isoforms.

Gene names and symbols associated with anti-Desmocollin 2 (DSC2) Antibodies

  • desmocollin 2 (DSC2) antibody
  • desmocollin 2 (Dsc2) antibody
  • ARVD11 antibody
  • AW228162 antibody
  • CDHF2 antibody
  • DG2 antibody
  • DGII/III antibody
  • DSC2 antibody
  • Dsc2a antibody
  • Dsc2b antibody
  • DSC3 antibody

Protein level used designations for anti-Desmocollin 2 (DSC2) Antibodies

cadherin family member 2 , desmocollin-2 , desmosomal glycoprotein II/III , epithelial type 2 desmocollin , desmocollin type 2 , desmocollin 2 , desmocollin-2-like

GENE ID SPECIES
1824 Homo sapiens
13506 Mus musculus
281128 Bos taurus
291760 Rattus norvegicus
403860 Canis lupus familiaris
455353 Pan troglodytes
100065829 Equus caballus
100413004 Callithrix jacchus
100543299 Meleagris gallopavo
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