Dihydrolipoyl Transacetylase Proteins (DLAT)

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). Additionally we are shipping Dihydrolipoyl Transacetylase Antibodies (86) and Dihydrolipoyl Transacetylase Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DLAT 1737 P10515
DLAT 81654 P08461
DLAT 235339 Q8BMF4
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Top Dihydrolipoyl Transacetylase Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
$9,626.73
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 to 18 Days
$640.00
Details
Escherichia coli (E. coli) Mouse His tag 100 μg 15 to 18 Days
$736.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Yeast Rat His tag   1 mg 60 to 71 Days
$3,589.67
Details
Human Un-conjugated   1 mg 6 Days
$6,182.79
Details

DLAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

Mouse (Murine) ,

More Proteins for Dihydrolipoyl Transacetylase (DLAT) Interaction Partners

Human Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. DLAT interacts with C1QBP in mitochondria.

  2. ongoing activation of PDCE2-specific B-cells in primary biliary cirrhosis

  3. Results show that DLAT and ACAT2 as upstream acetyltransferases of K76 and K294 in 6PGD protein.

  4. These findings were used to identify potentially antigenic sequences within PDC-E2 (an important hepatic autoantigen) that contain a DR0801 motif.

  5. Solution structure and characterisation of the human pyruvate dehydrogenase complex core assembly

  6. Data suggest that the catalytic site of pyruvate dehydrogenase complex E2 rather than the previously reported lipoyl binding peptide may contain immunodominant epitopes recognized by antimitochondrial antibodies in primary biliary cirrhosis.

  7. a novel HLA-A*0201-restricted epitope PDC-E2 165 to 174 was defined in patients with primary biliary cirrhosis.

  8. study of facilitated interaction between the pyruvate dehydrogenase kinase isoform 2 and the dihydrolipoyl acetyltransferase

  9. model of the pyruvate dehydrogenase complex formed by E2 and E2 plus the E3-binding protein and binding of the E1 and E3 components

  10. Having found that there is an excellent and almost unique match between the PDC-E2 autoepitope and a sequence in mycobacterial hsp65s, we tested the corresponding peptides for cross-reactivity using sera from 90 Spanish and British PBC patients.

  11. This study report two unrelated patients with pyruvate dehydrogenase deficiency caused by defects in the E2 subunit.

  12. epitope specificity of these PDC-E2 autoantibodies was distinctive suggesting that the mechanisms leading to loss of tolerance in the transplantation patients are distinct from primary biliary cirrhosis

  13. Species specificity in the interaction between hE1beta and hE2 in pyruvate dehydrogenase complex.

  14. tissue specificity of the autoimmune injury in primary biliary cirrhosis is a consequence of the unique characteristics of HIBECs during apoptosis and can be explained by exposure to immune system of intact immunoreactive PDC-E2 within apoptotic blebs.

Zebrafish Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. Deficiency of dihydrolipoamide S-acetyltransferase (Dlat) results in neurological dysfunction, congenital lactic acidosis, growth retardation, and early death.

Mouse (Murine) Dihydrolipoyl Transacetylase (DLAT) interaction partners

  1. These data reveal a central role for Dlat in the metabolic program regulated by E4F1 in basal keratinocytes.

  2. On the basis of our ChIP data and these previous findings, we hypothesize that PDC may modulate STAT5's ability to regulate gene expression by controlling histone or STAT5 acetylation

  3. breach of tolerance to PDC-E2 is probably the first event in the natural history of primary biliary cirrhosis in genetically susceptible hosts.

  4. a novel function of pyruvate dehydrogenase complex E2 in the nucleus in up-regulating the transactivating ability of STAT5

Dihydrolipoyl Transacetylase (DLAT) Protein Profile

Protein Summary

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Gene names and symbols associated with DLAT

  • midline uncoordinated (muc)
  • dihydrolipoamide S-acetyltransferase L homeolog (dlat.L)
  • dihydrolipoamide S-acetyltransferase (DLAT)
  • dihydrolipoamide S-acetyltransferase (Dlat)
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat)
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat)
  • 6332404G05Rik protein
  • anon-WO0118547.121 protein
  • DLAT protein
  • DLTA protein
  • Dmel\\CG5261 protein
  • EP(2)0816 protein
  • EP816 protein
  • PDC-E2 protein
  • PDCE2 protein
  • wu:fc14f10 protein
  • wu:fc21f08 protein
  • wu:fc86g11 protein
  • wu:fj57d06 protein

Protein level used designations for DLAT

CG5261-PA , CG5261-PB , CG5261-PC , CG5261-PD , CG5261-PE , CG5261-PF , Dihydrolipoyllysine-residue acetyltransferase , dihydrolipoamide acetyltransferase , dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , E2 component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , PBC , dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , pyruvate dehydrogenase complex component E2 , dihydrolipoyllysine-residue acetyltransferase , E2 , PDC-E2 , PDCE2 , fc86g11 , fj57d06 , no optokinetic nystagmus a , no optokinetic response b , noa , nrb

GENE ID SPECIES
34021 Drosophila melanogaster
398314 Xenopus laevis
419796 Gallus gallus
1737 Homo sapiens
489406 Canis lupus familiaris
397054 Sus scrofa
512723 Bos taurus
81654 Rattus norvegicus
100349212 Oryctolagus cuniculus
324201 Danio rerio
235339 Mus musculus
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