Dihydrolipoyl Transacetylase Proteins

DLAT encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC).

Data Quality
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Type
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    Protein
Target
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    Dihydrolipoyl Transacetylase (DLAT)
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Application
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  • 2
Reactivity
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Host
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Binding Specificity
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Conjugate
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Protein Type
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Format
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Suggested next Filters
10 Products
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityHuman
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3085256
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Insect Cells (Source), Purity >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot.
ReactivityMouse
Application Crys, ELISA, SDS, WB
Order details Cat. No. ABIN3125046
$9,371.15
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 60 Business Days
Recombinant Protein, Wheat germ (Source)
ISO
ReactivityHuman
Application AA, AP, ELISA, WB
Order details Cat. No. ABIN1351656
$230.67
2 μg
Plus shipping costs $45.00 and $22.00 dry ice
Delivery in 11 to 12 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityHuman
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN2120966
$640.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityHuman
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN3009180
$661.28
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityMouse
Application ELISA, IP, SDS, WB
Order details Cat. No. ABIN3009179
$731.63
Plus shipping costs $45.00
Delivery in 11 to 18 Business Days
Recombinant Protein, Escherichia coli (E. coli) (Source), Purity > 95 %
ReactivityMouse
Application IP, SDS, ELISA, WB
Order details Cat. No. ABIN2120968
$736.00
Plus shipping costs $45.00
Delivery in 15 to 18 Business Days
Recombinant Protein, HEK-293 Cells (Source), Purity > 80 % as determined by SDS-PAGE and Coomassie blue staining
ReactivityHuman
Application AbP, Func, PI, STD
Order details Cat. No. ABIN2719517
$888.80
20 μg
Plus shipping costs $45.00 and $22.00 dry ice
Will be delivered in 11 Business Days
Recombinant Protein, Yeast (Source), Purity > 90 %
ReactivityRat
Application ELISA
Order details Cat. No. ABIN1475200
$3,589.67
1 mg
Plus shipping costs $45.00
Delivery in 60 to 71 Business Days
Recombinant Protein
ReactivityHuman
Order details Cat. No. ABIN1062608
$6,182.79
Plus shipping costs $45.00
Will be delivered in 6 Business Days
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Dihydrolipoyl Transacetylase (DLAT) Protein Profile

Protein Summary

This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a cause of pyruvate dehydrogenase E2 deficiency which causes primary lactic acidosis in infancy and early childhood.

Gene names and symbols associated with DLAT

  • midline uncoordinated (muc) antibody
  • dihydrolipoamide S-acetyltransferase L homeolog (dlat.L) antibody
  • dihydrolipoamide S-acetyltransferase (DLAT) antibody
  • dihydrolipoamide S-acetyltransferase (Dlat) antibody
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (dlat) antibody
  • dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) (Dlat) antibody
  • 6332404G05Rik antibody
  • anon-WO0118547.121 antibody
  • DLAT antibody
  • DLTA antibody
  • Dmel\\CG5261 antibody
  • EP(2)0816 antibody
  • EP816 antibody
  • PDC-E2 antibody
  • PDCE2 antibody
  • wu:fc14f10 antibody
  • wu:fc21f08 antibody
  • wu:fc86g11 antibody
  • wu:fj57d06 antibody

Protein level used designations for DLAT

CG5261-PA , CG5261-PB , CG5261-PC , CG5261-PD , CG5261-PE , CG5261-PF , Dihydrolipoyllysine-residue acetyltransferase , dihydrolipoamide acetyltransferase , dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex) , 70 kDa mitochondrial autoantigen of primary biliary cirrhosis , E2 component of pyruvate dehydrogenase complex , M2 antigen complex 70 kDa subunit , PBC , dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex mitochondrial , dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial , pyruvate dehydrogenase complex component E2 , dihydrolipoyllysine-residue acetyltransferase , E2 , PDC-E2 , PDCE2 , fc86g11 , fj57d06 , no optokinetic nystagmus a , no optokinetic response b , noa , nrb

GENE ID SPECIES
34021 Drosophila melanogaster
398314 Xenopus laevis
419796 Gallus gallus
1737 Homo sapiens
489406 Canis lupus familiaris
397054 Sus scrofa
512723 Bos taurus
81654 Rattus norvegicus
100349212 Oryctolagus cuniculus
324201 Danio rerio
235339 Mus musculus