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DVL3 is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. Additionally we are shipping DVL3 Antibodies (14) and many more products for this protein.
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Dvl3 is overexpressed in human HCCs (show HCCS Proteins). The NP-Dvl3 is the more stable and active form of the protein and enhances HCC (show FAM126A Proteins) stemness.
we found that Wnt3a (show WNT3A Proteins) treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 (show DVL2 Proteins) and Dvl3. Our findings suggest a model of positive regulation of PKCzeta (show PRKCZ Proteins)-mediated Dvl (show DVL2 Proteins) signaling activity, to produce a strong and sustained response to Wnt3a (show WNT3A Proteins) treatment by stabilizing Dvl (show DVL2 Proteins) protein levels.
Studied and identified candidate biomarkers of biochemical recurrence (BCR (show BCR Proteins)) of prostate adenocarcinoma by integrating reverse-phase protein array (RPPA) and mRNA datafrom The Cancer Genome Atlas (TCGA). Found DVL3 was expressed in patients with a higher risk of BCR (show BCR Proteins). DVL3 may be a novel and easily applicable recurrence predictor of localised prostate adenocarcinoma.
two mutually exclusive functions of the DEP domain in Wnt (show WNT2 Proteins) signal transduction - binding to Frizzled to recruit Dishevelled (show DVL2 Proteins) to the receptor complex, is reported.
Genetic changes between MLH1 (show MLH1 Proteins) and MSH2 (show MSH2 Proteins) were significantly positively correlated (p = 0.032). We also noted a positive correlation between genetic changes of MSH2 (show MSH2 Proteins) and DVL3 genes (p = 0.034).
Data show that dishevelled (show DVL2 Proteins) proteins DVL1 (show DVL1 Proteins), 2 and 3 were exclusively expressed in chronic lymphatic leukaemia (CLL) cells as compared to normal peripheral blood mononuclear cells (PBMCs).
Kif26b, together with Dvl3/Daam1 (show DAAM1 Proteins), initiates cell polarity through the control of planar cell polarity-signaling pathway-dependent activation in endothelial cells.
DVL3 transcripts decreased in individuals with major depressive disorder
we demonstrate that normally ALFY attenuates the canonical Wnt (show WNT2 Proteins) signaling pathway via autophagy-dependent removal specifically of aggregates of DVL3 and not of Dvl1 (show DVL1 Proteins) or Dvl2 (show DVL2 Proteins).
All variants in DVL3 result in a -1 frameshift, indicating that these highly specific alterations might be a common cause of dominant Robinow syndrome.
This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
DSH homolog 3
, dishevelled 3 (homologous to Drosophila dsh)
, dishevelled, dsh homolog 3
, segment polarity protein dishevelled homolog DVL-3