anti-Dopachrome Tautomerase (DCT) Antibodies

Involved in regulating eumelanin and phaeomelanin levels. Additionally we are shipping DCT Kits (37) and DCT Proteins (9) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
DCT 290484  
DCT 13190 P29812
DCT 1638 P40126
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Top anti-DCT Antibodies at antibodies-online.com

Showing 10 out of 116 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-Dct Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Mouse Heart Host:  Mouse  Target Name:  DCT  Sample Tissue:  Mouse Skeletal Muscle  Antibody Dilution:  1ug/ml 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Dct Antibody Titration: 1.0 ug/ml Positive Control: Mouse Kidney 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of TRP2 staining in A375 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of TRP2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of DCT Antibody  in NCI-H460 cell line lysates (35ug/lane). This demonstrates the DCT antibody detected the DCT protein (arrow) 0.4 mL Log in to see 6 to 8 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of TRP2 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit Western blot analysis of TRP2 expression in Hela (A), A549 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of TRP2 expression in Hela (A), A549 (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from K562 cells, using DCT Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of A549 cells, using DCT Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of DCT Antibody (N-term) (ABIN652717) in K562, A375, Ramos cell line lysates (35 µg/lane). DCT (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma reacted with DCT Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of DCT Antibody (N-term) (ABIN653914) in A375 cell line lysates (35 µg/lane). DCT (arrow) was detected using the purified polyclonal antibody. DCT Antibody (N-term) (ABIN653914) IHC analysis in formalin fixed and paraffin embedded breast carcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$385.00
Details
Human Rabbit Un-conjugated ELISA, IF, WB 100 μL Log in to see 16 Days
$181.73
Details

Top referenced anti-DCT Antibodies

  1. Human Polyclonal DCT Primary Antibody for ICC, IF - ABIN4362889 : Pontén, Jirström, Uhlen: The Human Protein Atlas--a tool for pathology. in The Journal of pathology 2008 (PubMed)

  2. Human Polyclonal DCT Primary Antibody for IHC, IHC (p) - ABIN4362890 : Abad, Wieërs, Colau, Wildmann, Delair, Dhote, Brézin, Kawakami, Coulie, van der Bruggen: Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient. in Molecular vision 2014 (PubMed)

More Antibodies against DCT Interaction Partners

Mouse (Murine) Dopachrome Tautomerase (DCT) interaction partners

  1. soyasaponin Ag inhibited TRP2 expression in a dosedependent manner. Therefore, the depigmenting effect of soyasaponin Ag may be due to the inhibition of tyrosinase expression or the enhancement of tyrosinase degradation.

  2. MIF-2/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4-dependent mechanisms.

  3. the slaty mutant melanocytes seem to be more sensitive to ultraviolet rays and oxidative stress than black melanocytes.

  4. A novel murine model of vitiligo is established by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide.

  5. study indicates that tumor antigen (TRP2) expressed in MCMV induces a strong and long-lasting anti-melanoma effect through an antibody-dependent mechanism

  6. Vaccine formulations with synthetic long peptides for treating B16F10 skin melanoma fails to elicit strong CD8 T cell responses to self-differentiation antigens TRP-2 and gp100.

  7. level of gene targeting was not improved by the DSB induction, indicating a limited capacity of I-SceI to mediate homologous recombination at the Dct locus

  8. Recombinant dopachrome tautomerase was expressed and purified, without its carboxy-terminal transmembrane region. Analysis of dopachrome tautomerase tryptic peptides by MALDI-TOF/TOF determined N-glycosylation as a primary post-translational modification.

  9. Dopachrome tautomerase inactivation elevates the level of ROS, increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation

  10. the TRP-2 polypeptide folds in the endoplasmic reticulum (ER) in the presence of calnexin, until it reaches a dithiothreitol-resistant conformation enabling its ER exit to the Golgi

  11. Results describe the generation of a knockout of the dopachrome tautomerase gene in mice with effects restricted to pigment production and coat color.

  12. We found that ionophore monensin (Mon) and the quaternary amine chloroquine (CQ) discriminate between the traffic routes of TRP-2 and TRP-1

  13. The enzymatic activity of Dct may play a role in determining whether the eumelanin or pheomelanin pathway is preferred for pigment biosynthesis.

  14. These results suggest that the slaty mutation affects both eumelanin and pheomelanin synthesis in developmental stage-specific and skin site-specific manners.

  15. Slaty mutation blocks the melanosome maturation at stage III and affects the melanosome morphology (elliptical or spherical) in a developmental stage-specific manner.

  16. Eumelanin and pheomelanin may accumulate with difficulty in slaty-mutated melanocytes and be easily released from them during skin development. L-Tyr may stimulate this release.

  17. These results suggest that the slaty mutation inhibits the development of elliptical stage IV melanosomes and that L-Tyr restores the development of elliptical stage IV melanosomes

  18. Cytotoxicity toward targets loaded with a K(b)-restricted tyrosinase-related protein 2-derived peptide correlated with depigmentation in a mouse model of autoimmune vitiligo.

  19. mice lacking DCT displayed normal cardiac development but an increased susceptibility to atrial arrhythmias

Human Dopachrome Tautomerase (DCT) interaction partners

  1. High DCT expression is associated with progressive multiple sclerosis.

  2. High DCT expression is associated with HPV16 Infection.

  3. Data indicate that the caveolin-1 (CAV1) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent.

  4. The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes.

  5. Report dopachrome tautomerase expression in mealanocytic tumors.

  6. The results suggested that the miRNAs may be involved in MITF regulation of TYR, TYRP1 and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease.

  7. Data suggest that macrophage migration inhibitory factor (MIF) and d-dopachrome tautomerase (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK in LKB1 wild type and LKB1 mutant non-small cell lung carcinomas cells.

  8. human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 pathway

  9. Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population.

  10. Data suggest that OTX2 may regulate retinal pigment epithelium (RPE)-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE.

  11. Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients.

  12. Transgenic Dct regulates neural progenitor cell proliferation in a mouse model.

  13. No genetic susceptibility or increased risk attributed to the tyrosinase gene family in Vogt-Koyanagi-Harada disease in Japanese.

  14. Anemonin, an active compound of C. crassifolia, inhibits melanin synthesis by inhibiting the transcription of the genes encoding TYR, TRP1, and TRP2.

  15. we studied a possible role of dopachrome tautomerase in the oxidative stress response in the amelanotic WM35 melanoma cell line.

  16. We observe strong evidence for positive selection for DCT in Asians

  17. Tyrosinase-, gp100-, or TRP-2-specific CD8(+) T cells could not be identified in the peripheral blood of individuals with vitiligo [TRP-2].

  18. TRP-2 acts on quinone metabolites other than DOPAchrome, e.g., in the catecholamine pathway, and limits their deleterious effects.

  19. tyrosinase-related protein 2 (TRP-2) transcript is not detected in the peripheral blood mononuclear cells (PBMC) of vitiligo patients

  20. Expression profiling demonstrated that the DCT-expressing cell population expressed adrenergic and muscarinic receptors and displayed transcriptional profiles distinct from dermal melanocytes

DCT Antigen Profile

Protein Summary

Involved in regulating eumelanin and phaeomelanin levels.

Gene names and symbols associated with DCT

  • dopachrome tautomerase (DCT) antibody
  • dopachrome tautomerase (Dct) antibody
  • dopachrome tautomerase (dct) antibody
  • dopachrome tautomerase L homeolog (dct.L) antibody
  • DT antibody
  • RGD1564975 antibody
  • slaty antibody
  • slt antibody
  • TRP-2 antibody
  • TRP2 antibody
  • Tyrp-2 antibody
  • Tyrp2 antibody
  • zgc:109860 antibody

Protein level used designations for DCT

DT , L-dopachrome Delta-isomerase , L-dopachrome tautomerase , TRP-2 , TRP2 , dopachrome delta isomerase , dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2) , tyrosinase related protein 2 , tyrosinase-related protein 2 , L-dopachrome tautomerase-like , SLATY locus protein , tyrosinase-related protein-2 , dopachrome delta-isomerase , tyrosine-related protein 2

GENE ID SPECIES
280761 Bos taurus
574066 Sus scrofa
100170232 Ovis aries
290484 Rattus norvegicus
485520 Canis lupus familiaris
549915 Xenopus (Silurana) tropicalis
694577 Macaca mulatta
100058776 Equus caballus
100230498 Taeniopygia guttata
100381161 Xenopus laevis
100389709 Callithrix jacchus
100438537 Pongo abelii
100595345 Nomascus leucogenys
13190 Mus musculus
1638 Homo sapiens
395775 Gallus gallus
100353923 Oryctolagus cuniculus
100718804 Cavia porcellus
58074 Danio rerio
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