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Involved in regulating eumelanin and phaeomelanin levels. Additionally we are shipping DCT Kits (34) and DCT Proteins (8) and many more products for this protein.
Showing 10 out of 100 products:
Human Polyclonal DCT Primary Antibody for ICC, IF - ABIN4362889
Pontén, Jirström, Uhlen: The Human Protein Atlas--a tool for pathology. in The Journal of pathology 2008
Human Polyclonal DCT Primary Antibody for IHC, IHC (p) - ABIN4362890
Abad, Wieërs, Colau, Wildmann, Delair, Dhote, Brézin, Kawakami, Coulie, van der Bruggen: Absence of recognition of common melanocytic antigens by T cells isolated from the cerebrospinal fluid of a Vogt-Koyanagi-Harada patient. in Molecular vision 2014
soyasaponin Ag inhibited TRP2 expression in a dosedependent manner. Therefore, the depigmenting effect of soyasaponin Ag may be due to the inhibition of tyrosinase (show TYR Antibodies) expression or the enhancement of tyrosinase (show TYR Antibodies) degradation.
MIF-2 (show HSPA5 Antibodies)/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI (show SLPI Antibodies)- and ATF4 (show ATF4 Antibodies)-dependent mechanisms.
the slaty mutant melanocytes seem to be more sensitive to ultraviolet rays and oxidative stress than black melanocytes.
A novel murine model of vitiligo (show MITF Antibodies) is established by sequential prime/boost immunizations into the hind footpad and tail dermis with tyrosinase-related protein 2 (TRP2)-180 (SVYDFFVWL) peptide.
study indicates that tumor antigen (TRP2) expressed in MCMV induces a strong and long-lasting anti-melanoma effect through an antibody-dependent mechanism
Vaccine formulations with synthetic long peptides for treating B16F10 skin melanoma fails to elicit strong CD8 (show CD8A Antibodies) T cell responses to self-differentiation antigens TRP-2 and gp100 (show PMEL Antibodies).
level of gene targeting was not improved by the DSB induction, indicating a limited capacity of I-SceI to mediate homologous recombination at the Dct locus
Recombinant dopachrome tautomerase was expressed and purified, without its carboxy-terminal transmembrane region. Analysis of dopachrome tautomerase tryptic peptides by MALDI-TOF/TOF (show FEZF2 Antibodies) determined N-glycosylation as a primary post-translational modification.
Dopachrome tautomerase inactivation elevates the level of ROS (show ROS1 Antibodies), increases the numbers of sunburn cells and apoptotic cells, and decreases the amount of eumelanin in the epidermis upon exposure to chronic UVA radiation
the TRP-2 polypeptide folds in the endoplasmic reticulum (ER) in the presence of calnexin (show CANX Antibodies), until it reaches a dithiothreitol-resistant conformation enabling its ER exit to the Golgi
High DCT expression is associated with HPV16 Infection.
Data indicate that the caveolin-1 (CAV1 (show CAV1 Antibodies)) control on dopachrome tautomerase (DCT) gene expression, DCT post-translational processing, and subcellular distribution is cell phenotype-dependent.
The effect of DCT on UVR DNA damage responses and survival pathways in melanocytes was examined by knockdown experiments using melanoma cells, neonatal melanoblasts in monoculture and in co-culture with keratinocytes.
Report dopachrome tautomerase expression in mealanocytic tumors.
The results suggested that the miRNAs may be involved in MITF (show MITF Antibodies) regulation of TYR (show TYR Antibodies), TYRP1 (show TYRP1 Antibodies) and TYRP2, which provides a new clue for understanding the role of miRNAs in melanocyte dysfunctional disease.
Data suggest that macrophage migration inhibitory factor (MIF (show MIF Antibodies)) and d-dopachrome tautomerase (show DDT Antibodies) (d-DT) act cooperatively to inhibit steady-state phosphorylation and activation of AMPK (show PRKAA1 Antibodies) in LKB1 (show STK11 Antibodies) wild type and LKB1 (show STK11 Antibodies) mutant non-small cell lung carcinomas cells.
human TRP2 counteracts apoptotic cell death induction, possibly by means of its L-dopachrome tautomerase activity, and negatively affects the p53 (show TP53 Antibodies) pathway
Trp2 SNP2 allele is a risk factor for the development and severity of degenerative disc disease in a Chinese Han population.
Data suggest that OTX2 (show OTX2 Antibodies) may regulate retinal pigment epithelium (RPE (show RPE Antibodies))-specific target genes, such as DOPAchrome tautomerase (DCT), thereby maintaining the homeostasis of RPE (show RPE Antibodies).
Because TRP-2(181-190) overlaps with the known HLA-A*0201-presented epitope TRP-2(180-188), an 11mer peptide encompassing both epitopes might be of specific value for vaccination of a broad population of melanoma patients.
Involved in regulating eumelanin and phaeomelanin levels.
, L-dopachrome Delta-isomerase
, L-dopachrome tautomerase
, dopachrome delta isomerase
, dopachrome tautomerase (dopachrome delta-isomerase, tyrosine-related protein 2)
, tyrosinase related protein 2
, tyrosinase-related protein 2
, L-dopachrome tautomerase-like
, SLATY locus protein
, tyrosinase-related protein-2
, dopachrome delta-isomerase
, tyrosine-related protein 2