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The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. Additionally we are shipping DUSP1 Antibodies (127) and DUSP1 Proteins (8) and many more products for this protein.
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Human DUSP1 ELISA Kit - ABIN1130767
Khadir, Tiss, Abubaker, Abufarha, Al-Khairi, Cherian, John, Kavalakatt, Warsame, Al-Madhoun, Al-Ghimlas, Elkum, Behbehani, Dermime, Dehbi: MAP kinase phosphatase DUSP1 is overexpressed in human obese and modulated by physical activity. in American journal of physiology. Endocrinology and metabolism 2014
Downregulation of the expression of DUSP1 or protein phosphatase 1 led to a decline in the beta2adrenergic receptormediated dephosphorylation of ERK1/2 (show MAPK1/3 ELISA Kits).
the expression of DUSP1 was lower in OA FLSs than in normal FLSs, and DUSP1 may inhibit the expression of OA-associated mediators, MMP-13 (show MMP13 ELISA Kits) and COX-2 (show COX2 ELISA Kits), by suppressing the activation of p38 MAPK (show MAPK14 ELISA Kits) and JNK (show MAPK8 ELISA Kits) pathways in OA FLSs.
Curcumin suppressed CXCL5 (show CXCL5 ELISA Kits) expression by direct inhibition of IKKbeta (show IKBKB ELISA Kits) phosphorylation, and inhibition of p38 MAPK (show MAPK14 ELISA Kits) via induction of negative regulator MKP-1.
MKP-1 is a redox-regulated master controller of monocyte function and macrophage phenotype. (Review)
We propose a signaling cascade involving ARID1A, GADD45B and DUSP1 as mediators of the romidepsin effects in GCC (show GUCY2C ELISA Kits) cells.
this work indicates that suppression of JNK1 (show MAPK8 ELISA Kits)/2 activity by MKP-1 maintains PARP-1 (show PARP1 ELISA Kits) levels and suggests that MKP-1-mediated cisplatin resistance can be bypassed by PARP-1 (show PARP1 ELISA Kits) inhibition.
Mean morning and evening DUSP1 mRNA levels showed significant increase during Ramadan compared to Shabaan, however, its diurnal rhythm was maintained. Morning IL-1alpha mRNA expression remained significantly higher than in the evening during Ramadan, but was markedly decreased compared to Shabaan.
Methylation-mediated silencing of the DUSP-1 promoter does not appear to be associated with reduced expression, indicating the involvement of other factors in specific suppression of DUSP-1 in diabetes-associated cardiac hypertrophy.
Increased MAP2K6 (show MAP2K6 ELISA Kits), MAP4K3, and DUSP1 gene expressions in post-chemotherapy samples indicate a poor clinical outcome in osteosarcoma patients.
The aim of this review is to shed light on the role of four different phosphatases (PTEN, PP2A (show PPP2R4 ELISA Kits), CDC25 (show RASGRF1 ELISA Kits) and DUSP1) in five different solid tumors (breast cancer, lung cancer, pancreatic cancer, prostate cancer and ovarian cancer), in order to better understand the most frequent and aggressive primary cancer of the central nervous system, glioblastoma.
The cardiac ischemia/reperfusion injury - induced DUSP1 deficiency promoted the activation of JNK which upregulated the expression of the mitochondrial fission factor (Mff).
Study demonstrates that MKP-1 serves as a master-regulator of macrophage phenotype and function and its dysregulation by metabolic stress may be a major contributor to atherogenesis and the progression of atherosclerotic plaques.
FAM3D inhibits glucagon (show GCG ELISA Kits) secretion via MKP1-dependent suppression of ERK1/2 (show MAPK1/3 ELISA Kits) signaling.
these data show that MKP-1 is an important endogenous suppressor of innate immune responses involved in the regulation of blood-testis barrier barrier dynamic
MKP-1 regulates IL-1beta production through stabilization of HIF-1alpha. The induction of HIF-1alpha protein in MKP-1 deficiency is partly due to p38MAPK activation in response to LPS.
this work identifies a previously unrecognized role for DUSP1 in regulating autophagy.
c-FOS and DUSP1 expression levels determine the threshold of tyrosine kinase (show TYRO3 ELISA Kits) inhibitor (TKI) efficacy, such that growth-factor-induced expression of c-FOS and DUSP1 confers intrinsic resistance to TKI therapy in a wide-ranging set of leukemias.
PTHrP counteracts the pro-apoptotic actions of reactive oxygen species by a mechanism dependent on MKP1-induced dephosphorylation.
A2AR (show ADORA2A ELISA Kits) signaling regulates both basal and LPS (show TLR4 ELISA Kits)-induced DUSP1 levels in macrophages via activating the adenylate cyclase pathway.
these data suggest an important role for DUSPs in regulating MAPK (show MAPK1 ELISA Kits) dephosphorylation, with an emphasis on DUSP1, during early adipogenesis
MKP-1 is the specific phosphatase induced by AngII and involved in the negative feedback mechanism ensuring adequate ERK1/2 (show MAPK1/3 ELISA Kits)-mediated aldosterone production in response to the hormone.
Agonist stimulation of vascular smooth muscle increases PKC (show FYN ELISA Kits) activity, which, in turn, increases MKP-1 activity and maintains MAPK1 (show MAPK1 ELISA Kits) activity at submaximal values.
The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
dual specificity protein phosphatase 1
, dual specificity phosphatase 1
, MAP kinase phosphatase 1
, dual specificity protein phosphatase hVH1
, mitogen-activated protein kinase phosphatase 1
, protein-tyrosine phosphatase CL100
, serine/threonine specific protein phosphatase
, mitogen-activated protein kinase phosphatase-1
, protein tyrosine phosphatase, non-receptor type 16
, protein-tyrosine phosphatase 3CH134
, protein-tyrosine phosphatase ERP
, 3CH134/CL100 PTPase
, MAP kinase phosphatase-1
, mitogen-activated protein (MAP) kinase phosphatase-1
, oxidative stress-inducible protein tyrosine phosphatase
, protein tyrosine phosphatase non-receptor type 16
, protein-tyrosine phosphatase non-receptor type 16
, MAPK phosphatase 1