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The protein encoded by DUSP8 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping Dual Specificity Phosphatase 8 Proteins (3) and many more products for this protein.
Showing 10 out of 71 products:
Human Polyclonal DUSP8 Primary Antibody for IHC (p), ELISA - ABIN545061
Berger, Buschbeck, Bange, Ullrich: Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2. in Cancer genetics and cytogenetics 2005
Show all 3 Pubmed References
Human Polyclonal DUSP8 Primary Antibody for ELISA, WB - ABIN257844
Martell, Seasholtz, Kwak, Clemens, Dixon: hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase. in Journal of neurochemistry 1995
The phosphorylation of the M3/6 phosphatase by JNK in response to stress stimuli results in attenuation of phosphatase activity and acceleration of JNK activation.
DUSP8 is genetically linked to alcohol dependence and was found on chromosome 11p15.5
Because this variant of hVH-5 lacked intronic sequences in its genomic structure, we suggest it might be a processed pseudogene of hVH-5.
DUSP8 controls stress-induced ERK1/2 signaling in cardiac myocytes.
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2.
dual specificity phosphatase 8
, dual specificity protein phosphatase 8-like
, dual specificity protein phosphatase 8
, H1 phosphatase, vaccinia virus homolog
, dual specificity protein phosphatase hVH-5
, serine/threonine specific protein phosphatase
, neuronal tyrosine threonine phosphatase 1
, neuronal tyrosine/threonine phosphatase 1