DUSP8 Products
(Dual Specificity Phosphatase 8 (DUSP8))
Categories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. [provided by RefSeq, Jul 2008].
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Featured DUSP8 Categories
DUSP8 Antibodies
High quality antibodies with extensive validation data.
DUSP8 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DUSP8 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN7242101
Quantity
200 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (1)
- (2)
Cat. No.
ABIN545061
Quantity
400 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN7266849
Quantity
100 μL
Datasheet
Datasheet
Recommended DUSP8 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352144
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3079104
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3131391
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DUSP8 products
: "Integrin-linked Kinase Controls Renal Branching Morphogenesis via Dual Specificity Phosphatase 8." in: Journal of the American Society of Nephrology : JASN, Vol. 27, Issue 5, pp. 1465-77, (2016) (PubMed).: "Identification of a transcriptionally active hVH-5 pseudogene on 10q22.2." in: Cancer genetics and cytogenetics, Vol. 159, Issue 2, pp. 155-9, (2005) (PubMed).
: "hVH-5: a protein tyrosine phosphatase abundant in brain that inactivates mitogen-activated protein kinase." in: Journal of neurochemistry, Vol. 65, Issue 4, pp. 1823-33, (1995) (PubMed).
Synonyms and alternative names related to DUSP8
dual specificity phosphatase 8 (DUSP8), dual specificity phosphatase 8 (dusp8), dual specificity phosphatase 8a (dusp8a), dual specificity protein phosphatase 8 (DSP8), dual specificity phosphatase 8 (Dusp8), dual specificity protein phosphatase 8 (LOC615727), 5530400B01Rik, AI593498, C11orf81, DUSP8, HB5, Hb5, HVH-5, HVH8, M3/6, Nttp1, zgc:77593Protein level used designations for DUSP8
- dual specificity phosphatase 8
- dual specificity protein phosphatase 8-like
- dual specificity protein phosphatase 8
- H1 phosphatase, vaccinia virus homolog
- dual specificity protein phosphatase hVH-5
- serine/threonine specific protein phosphatase
- neuronal tyrosine threonine phosphatase 1
- neuronal tyrosine/threonine phosphatase 1
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