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The protein encoded by DUSP9 is a member of the dual specificity protein phosphatase subfamily. Additionally we are shipping DUSP9 Antibodies (70) and DUSP9 Proteins (5) and many more products for this protein.
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Human DUSP9 ELISA Kit for Sandwich ELISA - ABIN859187
Hui, Wang, Zhou, Ma, Yan, Zhang, Wang, Yu: Association Between MKP-1, BDNF, and Gonadal Hormones with Depression on Perimenopausal Women. in Journal of women's health (2002) 2015
The results of this study, combined with previous studies, suggested that therapeutic intervention to increase the expression or activity of DUSP9 may enable the activation of anti-proliferation signals in malignant cells.
A possible use for DUSP9 as CIMP marker.
DUSP9 protein levels were markedly suppressed in severe pre-eclampsia, but not in severe IUGR. This suppression might be attributable to the prolonged hypoxic conditions found in pre-eclampsia.
The DUSP9 locus is a common susceptibility locus for type 2 diabetes across different ethnicities, and 6 loci identified in South Asian genome-wide association studies also have significant effect on susceptibility to Japanese type 2 diabetes.
decreased expression of DUSP-9 is associated with poor prognosis in ccRCC.
DUSP9/MKP-4 is a bona fide target of PKA signaling and attenuation of DUSP9/MKP-4 function can mediate cross-talk between the PKA pathway and MAPK signaling through both ERK1/2 and p38alpha in vivo
2.7 A resolution crystal structure of the catalytic domain of MKP-4 (MKP-4C) is presented
microtubule disruption by MKP4 provides a novel mechanism for tumor suppression by a cytosolic MKP
Data demonstrate the epigenetic similarity of sex-matched ESCs and EGCs and identify DUSP9 as a regulator of female-specific hypomethylation.
we have identified in this study the MAPK phosphatase Dusp9 as selectively expressed in mouse pDCs.
these findings identify DUSP9 as a critical mediator of BMP signaling to control appropriate ERK activity critical for ESC fate determination.
negatively regulates insulin signaling and, consequently, may contribute to the pathogenesis of insulin resistance
DUSP9/MKP-4 is essential for placental organogenesis but is otherwise dispensable for mammalian embryonic development.
Data show that Dusp9 transcripts is expressed in partially overlapping patterns that correspond to regions of active FGF signaling, suggesting combinatorial roles in negative regulation of this pathway during ear development.
Dusp9 has a protective effect against the development of insulin resistance through its ability to dephosphorylate and inactivate crucial mediators of stress-induced insulin resistance, such as ERK and JNK
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product shows selectivity for members of the ERK family of MAP kinases, is expressed only in placenta, kidney, and fetal liver, and is localized to the cytoplasm and nucleus.
dual specificity protein phosphatase 9
, map kinase phosphatase 4
, mitogen-activated protein kinase phosphatase 4
, serine/threonine specific protein phosphatase
, dual-specificity MAP kinase phosphatase 4
, dual specificity phosphatase 9
, LOW QUALITY PROTEIN: dual specificity protein phosphatase 9