anti-E2F Transcription Factor 6 (E2F6) Antibodies

E2F6 encodes a member of the E2F transcription factor protein family. Additionally we are shipping E2F6 Proteins (3) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
E2F6 1876 O75461
E2F6 50496 O54917
E2F6 313978  
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Top anti-E2F6 Antibodies at

Showing 10 out of 91 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-E2F6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  HepG2 cell lysate E2F6 is supported by BioGPS gene expression data to be expressed in HepG2 Human Lung 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: E2f6 Sample Type: Rat Thymus lysates Antibody Dilution: 1.0ug/ml 100 μL 2 to 3 Days
Cow Rabbit Un-conjugated ChIP, IHC, WB ChIP analysis of Mouse ES cell nuclear lysate, incubated for 16 hours at 4°C. Cross-linking (X-ChIP) using formaldehyde for 10 minutes. Positive control: Tuba3. Negative Control: Beta-Actin. Detection step: Real-time PCR. Immunohistochemical analysis of E2F6 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL 13 to 14 Days
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB Western blot analysis on HepG2 cell lysate using E2F6 Antibody,The lane on the left is treated with the antigen-specific peptide. ABIN6266532 staining HepG2 by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody. 100 μL 11 to 12 Days
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells, using E2F6 Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using E2F6 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg 2 to 3 Days
Human Rabbit Un-conjugated ChIP, IF, IHC, IP, WB 100 μL 11 to 13 Days
Human Rabbit Un-conjugated ELISA, IHC, IHC (p), WB 50 μL 11 to 14 Days
Dog Rabbit Un-conjugated WB 100 μL 11 to 14 Days
Dog Rabbit Un-conjugated IHC, IHC (p), WB 100 μL 11 to 14 Days

Top referenced anti-E2F6 Antibodies

  1. Human Polyclonal E2F6 Primary Antibody for ELISA, ICC - ABIN6261413 : Ai, Zhang, Gao, Qin, Zhong, Gu, Li, Qiao, Tian, Cui, Yang, Bi, Xiao, Chen, Liu, Zhou, Sun, Yang: Sesquiterpene binding Gly-Leu-Ser/Lys-"co-adaptation pocket" to inhibit lung cancer cell epithelial-mesenchymal transition. in Oncotarget 2018 (PubMed)

  2. Human Polyclonal E2F6 Primary Antibody for ELISA, WB - ABIN4306784 : McLaughlin-Drubin, Huh, Münger: Human papillomavirus type 16 E7 oncoprotein associates with E2F6. in Journal of virology 2008 (PubMed)

  3. Cow (Bovine) Polyclonal E2F6 Primary Antibody for IHC, WB - ABIN2779510 : Lazrek, Goffard, Schanen, Karquel, Bocket, Lion, Devaux, Hedouin, Gosset, Hober: Detection of hepatitis C virus antibodies and RNA among medicolegal autopsy cases in Northern France. in Diagnostic microbiology and infectious disease 2006 (PubMed)
    Show all 2 Pubmed References

More Antibodies against E2F6 Interaction Partners

Human E2F Transcription Factor 6 (E2F6) interaction partners

  1. Target gene prediction software indicated that E2F6 was the potential downstream target gene of miR-425. E2F6 expression was found to be negatively regulated by miR-425 in clear cell renal carcinoma.

  2. LINC01436 exerted biological functions by acting as a microRNA (miR)-30a-3p sponge to regulate the expression of its target gene EPAS1.

  3. data demonstrated that E2F6 could regulate the proliferation, invasion and apoptosis of gastric carcinoma (GC) cells via inhibiting the expression of CASC2, suggesting that E2F6/CASC2 axis is another regulator of GC progression

  4. An estrogen-mediated E2F6 ceRNA network epigenetically and competitively inhibits microRNA-193a activity, promoting ovarian cancer stemness and tumorigenesis.

  5. This analysis showed a relative increase in the expression of E2F6 in gastric adenocarcinoma with no lymph node metastasis (chi (2), P = 0.04 and OR, P = 0.08), while overexpression of RhoA and SMUG1 was found more often in the diffuse subtype of gastric adenocarcinoma as compared to the intestinal subtype.

  6. E2F1 forms a protein complex with EBNA3C and E2F6, and EBNA3C competes with E2F1 for E2F6 binding. E2F6 is also recruited by EBNA3C to the E2F1 promoter, which is critical for EBNA3C-mediated cell proliferation.

  7. miR-185 suppresses tumor proliferation by directly targeting E2F6 and DNMT1 and indirectly upregulating BRCA1 in triple-negative breast cancer.

  8. Analysis data from a panel of cell cycle transcription factors (E2F1, E2F4, E2F6, and GABPA) finds that a set of core cell cycle genes regulated in both U2OS and HeLa cells are bound by multiple cell cycle transcription factors.

  9. After replication stress, the checkpoint kinase Chk1 phosphorylates E2F6, leading to its dissociation from promoters. This promotes E2F-dependent transcription, which mediates cell survival by preventing DNA damage and cell death

  10. findings indicate an inhibitory role of E2F6 in the regulation of IL-13 and allergy

  11. E2F6 may recruit BRG1 in transcriptional regulation of genes important for G1/S phase transition of the cell cycle.

  12. data suggest that E2F- and Myc-responsive genes are coregulated by E2F6 complex in quiescent cells

  13. results suggest that E2F6 represses transcription of the brca1, ctip, art27, hp1alpha, and the rbap48 genes and depletion of E2F6 resulted in the recruitment of E2F1 to the target promoters

  14. contains nine exons distributed along 20.4kbp of genomic DNA on chromosome 2 leading to the transcription of six alternatively spliced E2F6 mRNAs that encode four different E2F6 proteins

  15. E2F6 does not contain the domains required for modulation of squamous differentiation

  16. showed that E2F6, DP1, EPC1, EZH2, and Sin3B co-elute, suggesting the identification of a novel E2F6 complex that exists in vivo in both normal and transformed human cell lines

  17. functions as a repressor of E2F-dependent transcription during S phase

  18. the expression of the E2F6 repressor is influenced at the transcriptional level by E2F family members and suggest that interplay among these transcriptional regulators, especially E2F1, may be critical for cell cycle regulation

  19. PHC3 and E2F6 showed nuclear colocalization in a punctate pattern which was not seen in proliferating cells suggesting that PHC3 may be part of an E2F6-polycomb complex that has been shown to occupy and silence target promoters in G(0)

  20. E2F-6 inhibited Apaf-1 upregulation by competing with E2F-1 for promoter binding. It enhanced the clonogenic growth of granulocyte, erythroid, macrophage, & megakaryocyte cells.It may prevent hematopoietic progenitor cell loss during proliferation.

Mouse (Murine) E2F Transcription Factor 6 (E2F6) interaction partners

  1. E2F6 suppresses Mdm2 expression in cells harboring the SNP309G allele but not the SNP309T allele.

  2. By comparison in HeLa, Dox induced apoptosis through upregulation of endogenous E2F1 involving post-transcriptional mechanisms, while E2F6 was down regulated with induction of the Checkpoint kinase-1 and proteasome degradation. These data imply that E2F6 serves to modulate E2F activity and protect cells including cardiomyocytes from apoptosis and improve survival.

  3. These data reveal a novel interplay between the E2F pathway, beta2-adrenergic/PKA/PDE4D, and ERK/c-Src axis in fine tuning the pathological hypertrophic growth response.

  4. E2f6 was similarly bound to the proximal promoter regions both in embryonic stem cells (ESCs) and epiblast stem cells (EpiSCs)

  5. Data suggest that during development, E2F6 participates in the recruitment of polycomb proteins to specific target promoters.

  6. The 5' untranslated regions of E2F6 and E2F6b are unusually long, and they contain several upstream AUG codons followed by short reading frames. Our results suggest that translation of E2F6b is initiated by internal ribosome entry.

  7. E2F6 is essential for the long-term somatic silencing of certain male-germ-cell-specific genes, but it is dispensable for cell-cycle regulation.

  8. E2F6 silences SMC1beta and STAG3 in somatic cells

  9. This analysis shows that E2f6 and Bmi1 cooperate in the regulation of Hox genes, and consequently axial skeleton development, but not in the repression of the Ink4a-Arf locus.

  10. possesses a broad ability to bind to and regulate the meiosis-specific gene population

E2F6 Antigen Profile

Protein Summary

This gene encodes a member of the E2F transcription factor protein family. E2F family members play a crucial role in control of the cell cycle and of the action of tumor suppressor proteins. They are also a target of the transforming proteins of small DNA tumor viruses. Many E2F proteins contain several evolutionarily conserved domains: a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. The encoded protein of this gene is atypical because it lacks the transactivation and tumor suppressor protein association domains. It contains a modular suppression domain and is an inhibitor of E2F-dependent transcription. The protein is part of a multimeric protein complex that contains a histone methyltransferase and the transcription factors Mga and Max. Multiple transcript variants have been reported for this gene, but it has not been clearly demonstrated that they encode valid isoforms.

Gene names and symbols associated with E2F6

  • E2F transcription factor 6 (E2F6) antibody
  • E2F transcription factor 6 (E2f6) antibody
  • AI462434 antibody
  • E2F-6 antibody
  • E2F6b antibody
  • EMA antibody

Protein level used designations for E2F6

E2F transcription factor 6 , transcription factor E2F6 , E2F-6 , E2F-binding site-modulating activity protein , transcriptional repressor E2F6

100230762 Taeniopygia guttata
100347358 Oryctolagus cuniculus
1876 Homo sapiens
609996 Canis lupus familiaris
514085 Bos taurus
50496 Mus musculus
313978 Rattus norvegicus
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