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EGFL7 encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. Additionally we are shipping EGFL7 Antibodies (75) and EGFL7 Proteins (13) and many more products for this protein.
Showing 4 out of 21 products:
Human EGFL7 ELISA Kit for Sandwich ELISA - ABIN1874436
Hansen, Andersen, Olsen, Sørensen, Jakobsen: Prognostic importance of circulating epidermal growth factor-like domain 7 in patients with metastatic colorectal cancer treated with chemotherapy and bevacizumab. in Scientific reports 2017
we demonstrate for the first time the mechanisms by which lumens are generated within the major vessels in Xenopus and implicate EGFL7 in modulating cell shape and cell-cell junctions to drive proper lumen morphogenesis.
CASZ1/Egfl7/RhoA (show RHOA ELISA Kits) pathway is necessary for promoting endothelial cell behaviors associated with proper vascular assembly.
Under up-regulation of TIE2 (show TEK ELISA Kits)-R849W, egfl7 could be considered a potential reason for venous defects. Moreover, the wnt (show WNT2 ELISA Kits) pathway may perform an important role as a key trigger for head multi-malformations.
These data suggest that Egfl7 provides endothelial cells (EC) with a cue for their extension into the vascular area and in establishing EC cell polarity.
EGFL7 provides a proper microenvironment for endothelial cell migration, thereby enabling accurate patterning.
EGFL7 reduces CNS inflammation in the experimental autoimmune encephalomyelitis mouse model of multiple sclerosis.
Egfl7 is crucial for placental vascularization and embryonic growth.
the angiogenic factor (show VEGFA ELISA Kits) Egfl7 activates the Flt3/Flt3 (show FLT3 ELISA Kits) ligand (show FLT3LG ELISA Kits) pathway and is a key molecular driver enforcing thymus progenitor generation and thereby directly links endothelial cell biology to the production of T cell-based adaptive immunity
EGFL7 is required for VEGF (show VEGFA ELISA Kits) upregulation of the Akt (show AKT1 ELISA Kits)/Erk (1 (show MAPK3 ELISA Kits)/2) pathway during angiogenesis.
EGFL7 enhances EGFR (show EGFR ELISA Kits)-AKT (show AKT1 ELISA Kits) signaling, epithelial-mesenchymal transition, and metastasis of gastric cancer cells.
Egfl7 could be a HIF-1alpha (show HIF1A ELISA Kits) responsive gene regulated by oxygen tension.
Using the BPH (show GLI3 ELISA Kits)/5 model of pre-eclampsia (PE), we show that the downregulation of Egfl7 in compromised placentas occurs prior to the onset of characteristic maternal signs of PE.
egfl7 is initially expressed in all endothelial cells and then is progressively restricted to veins and to their neighbouring capillaries.
EGFL7 is expressed in the bone microenvironment and has a role in promoting endothelial cell migration and tube-like structure formation through integrin-mediated pathways.
Expression of Egfl7 in breast and lung carcinoma cells accelerates tumor growth and metastasis in immunocompetent mice but not in immunodeficient mice.
EGFL7 was found to be a potential predictor for HCC survival and metastasis state.
Levels of both EGFL7 mRNA and EGFL7 protein are increased in blasts of patients with acute myeloid leukemia (show BCL11A ELISA Kits) (AML (show RUNX1 ELISA Kits)) compared with normal bone marrow cells. High EGFL7 mRNA expression associates with lower complete remission rates, and shorter event-free and overall survival in older (age >/=60 y) and younger (age <60 y) patients with cytogenetically normal AML (show RUNX1 ELISA Kits).
In conclusion, miR (show MLXIP ELISA Kits)-126 could inhibit tumor proliferation and angiogenesis of hepatocellular carcinoma by down-regulating EGFL7 expression
This phase II trial evaluated the efficacy of parsatuzumab (also known as MEGF0444A), a humanized anti-EGFL7 IgG1 monoclonal antibody, in combination with modified FOLFOX6 (mFOLFOX6) (folinic acid, 5-fluorouracil, and oxaliplatin) bevacizumab in patients with previously untreated metastatic colorectal cancer
Oncogenic activation of EGFRwt in GBM is likely maintained by a continuous EGFL7 autocrine flow line.
our results indicated epidermal growth factor-like domain multiple 7 protein participates in growth hormone-secreting pituitary adenoma proliferation and invasion regulation via Notch2/DLL3 signaling pathway. These findings raised the possibility that epidermal growth factor-like domain multiple 7 protein might serve as a useful biomarker to assess growth hormone-secreting pituitary adenoma invasion and prognosis
Egfl7 is thus an endogenous and constitutive repressor of blood vessel endothelial cell activation in normal and inflammatory conditions and participates in a loop of regulation of activation of these cells by pro-inflammatory cytokines.
Up-regulated MALAT1 promoted the invasion and metastasis of GC, and the increase of EGFL7 expression was a potential mechanism via altering its H3 histone (show HIST1H3B ELISA Kits) acetylation level
These findings suggest that the stimulating effect of EGFL7-ESCs on fibroblast proliferation and migration may provide a useful strategy for wound healing.
A gene expression study was conducted to investigate the levels of Egfl7 and miRNA126-5p in human carotid artery atherosclerotic plaques
This gene encodes a secreted endothelial cell protein that contains two epidermal growth factor-like domains. The encoded protein may play a role in regulating vasculogenesis. This protein may be involved in the growth and proliferation of tumor cells. Alternate splicing results in multiple transcript variants.
EGF-like-domain, multiple 7
, epidermal growth factor-like protein 7
, EGF-like protein 7
, NEU1 protein
, NOTCH4-like protein
, multiple EGF-like domains protein 7
, multiple epidermal growth factor-like domains protein 7
, vascular endothelial statin
, vascular endothelial-statin
, EGF-like domain 7
, EGF-like domain-containing protein 7
, Estrogen-regulated protein CBL20 20.4kD
, Estrogen-regulated protein CBL20, 20.4kD
, multiple EGF-like domain protein 7
, multiple epidermal growth factor-like domain protein 7