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Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Additionally we are shipping Ectonucleoside Triphosphate diphosphohydrolase 1 Antibodies (215) and Ectonucleoside Triphosphate diphosphohydrolase 1 Kits (15) and many more products for this protein.
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Extracellular ATP hydrolysis via NTPDase1 action inhibits synaptic transmission by pannexin 1 (show PANX1 Proteins)-mediated increase in pH buffering of the synaptic cleft.
The peripheral blood mononuclear cells (PBMC) from the transgenic pigs were more resistant to lysis by pooled complement-preserved normal human serum than that from wild type (WT) pig. Accordingly, GGTA1 (show GGTA1 Proteins) mutated piglets expressing hCD39 will provide a new organ source for xenotransplantation research
Phosphoantigens (pAgs) induced expression of the ecto-ATPase CD39, which, however, not only hydrolyzed ATP but also abrogated the gammadelta T cell receptor (TCR) agonistic activity of self and microbial pAgs.
These studies showed that the G allele of rs3176891 marks a haplotype associated with increased clotting and platelet aggregation attributable to a promoter variant associated with increased transcription, expression, and activity of NTPDase1.
Transgenic expression of human CD39 is associated with increased renal fibrosis after ischemia in mice.
CD39 overexpression protects against cerebral ischemia in a transgenic mouse model.
Ablation of CD73 minimally effects in vivo thrombosis, but increased CD39 expression on hematopoietic-derived cells, especially monocytes, attenuates in vivo arterial thrombosis.
Data show that Th17(CD39+) cells are markedly diminished and fail to generate AMP (show APRT Proteins)/adenosine, thereby limiting control of both target cell proliferation and IL-17 (show IL17A Proteins) production in juvenile autoimmune liver disease (AILD).
concluded that CD39 and CD73 are molecular targets for the development of drugs for ALF (show GTF2A1L Proteins) patients care
Oxidized low density lipoproteins modulate CD39 and CD73 activity in the endothelium.
this study shows that T-cell expression of CD39 was higher in acute exacerbations of chronic obstructive pulmonary disease patients than stable COPD (show ARCN1 Proteins) patients or healthy controls
Deletion of CD39 and CD73 or both caused an inhibition of the microglia ramified phenotype in the brain with a reduction in the length of processes, branching frequency and number of intersections with Sholl spheres. In vitro, unlike wild-type microglia, cd39-/- and cd73-/- microglial cells were less complex and did not respond to ATP with the transformation into a more ramified phenotype.
CD39 expression by Th17 cells allows the depletion of ATP and is crucial for IL-10 (show IL10 Proteins) production and survival during the resolution of intestinal inflammation.
Cardiac-specific expression of CD39 reduces myocardial dysfunction and infarct size following ischemia-reperfusion injury
Data indicate that adenosine and CGS21680 upregulate CD39 and CD73 via E2F-1 (show E2F1 Proteins) and CREB (show CREB1 Proteins).
Acute cigarette smoke exposure induced CD39 upregulation in murine lungs and BALF cells. CD39 inhibition and deficiency led to augmented lung inflammation.
T Lymphocyte Inhibition by Tumor-Infiltrating Dendritic Cells Involves Ectonucleotidase CD39 but Not Arginase-1 (show ARG1 Proteins).
CD39 role in neuroinflammation: CD39 defines regulatory phenotypes in CD4 (show CD4 Proteins)-positive T cells.
data suggest that CD39 expression in liver allografts modulates tissue injury
these data establish CD39 as a regionalized regulator of atherogenesis that is driven by shear stress.
The Na-K-2Cl cotransporter (show SLC12A1 Proteins) was downregulated by high-sodium diet in wild-type mice, but it increased in transgenic mice overexpressing human CD39
CD39 and CD73 and their enzymatic activities that convert extracellular nucleotides are highly expressed and could have special function in the valve
Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides.
, NTPDase 8
, ectonucleoside triphosphate diphosphohydrolase 1
, liver ecto-ATP diphosphohydrolase
, CD39 antigen
, NTPDase 1
, ecto-ATP diphosphohydrolase 1
, ecto-ATPDase 1
, ecto-ATPase 1
, lymphoid cell activation antigen