anti-Embryonic Ectoderm Development (EED) Antibodies

EED encodes a member of the Polycomb-group (PcG) family. Additionally we are shipping Embryonic Ectoderm Development Kits (31) and Embryonic Ectoderm Development Proteins (17) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EED 8726 O75530
EED 13626 Q921E6
EED 293104  
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Top anti-Embryonic Ectoderm Development Antibodies at antibodies-online.com

Showing 10 out of 96 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IF, WB WB Suggested Anti-EED Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:2500  Positive Control:  OVCAR-3 cell lysate EED is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells WB Suggested Anti-EED  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.500  Positive Control: OVCAR-3 cell lysate  EED is strongly supported by BioGPS gene expression data to be expressed in Human OVCAR3 cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-EED Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>HepG2 cell lysate Host:  Rabbit  Target Name:  EED  Sample Type:  HepG2  Lane A:  Primary Antibody  Lane B:  Primary Antibody + Blocking Peptide  Primary Antibody Concentration:  4.0ug/mL  Peptide Concentration:  2.0ug/mL  Lysate Quantity:  25ug/lane  Gel Concentration:  12% 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Eed Antibody   Titration: 1.0 ug/ml   Positive Control: Rat Muscle 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB ABIN6269534 at 1/100 staining human heart tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269534 at 1/100 staining rat lung tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Log in to see 11 to 12 Days
$450.00
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of extracts of virous , using EED antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6277551 at 1/100 staining Mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of EED in lysates of HeLa?, using EED Antibody(ABIN6270381). 100 μL Log in to see 11 to 12 Days
$450.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: EED Antibody [NBP2-38907] - Staining of human cell line CACO-2 shows positivity in nucleus and nucleoli. Immunohistochemistry: EED Antibody [NBP2-38907] - Staining of human colon shows moderate nuclear positivity in glandular cells. 0.1 mL Log in to see 7 to 9 Days
$491.63
Details

Top referenced anti-Embryonic Ectoderm Development Antibodies

  1. Cow (Bovine) Polyclonal EED Primary Antibody for IF, WB - ABIN2776407 : Rakotobe, Violot, Hong, Gouet, Boulanger: Mapping of immunogenic and protein-interacting regions at the surface of the seven-bladed beta-propeller domain of the HIV-1 cellular interactor EED. in Virology journal 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal EED Primary Antibody for ELISA, WB - ABIN522175 : Martin, Popov, Aguilo, OLoghlen, Raguz, Snijders, Dharmalingam, Li, Thymiakou, Carroll, Zeisig, So, Peters, Episkopou, Walsh, Gil: Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK?a regulation. in The EMBO journal 2013 (PubMed)

More Antibodies against Embryonic Ectoderm Development Interaction Partners

Human Embryonic Ectoderm Development (EED) interaction partners

  1. we present a patient with a clinical diagnosis of Weaver (show KCNJ6 Antibodies) syndrome and novel de novo sequence variant in EED. Our observation together with previous reports [2, 3, 5] suggests that EED gene testing is warranted in patients with the overgrowth syndrome features and suspicion of Weaver (show KCNJ6 Antibodies) syndrome with normal results for EZH2 (show EZH2 Antibodies) gene sequencing.

  2. Data suggest the polycomb (show CBX2 Antibodies) repressive complex 2 subunits EZH2 (show EZH2 Antibodies), SUZ12, and EED protein axis as promising therapeutic target for treating sarcoma.

  3. we analyzed eight probands with clinically suspected Weaver syndrome by whole-exome sequencing and identified three mutations: a 25.4-kb deletion partially involving EZH2 and CUL1 ,a missense mutation , and a missense mutation in SUZ12 inherited from her father .In vitro functional analyses demonstrated that the identified EED and SUZ12 missense mutations cause decreased decreased trimethylation of lysine 27 of H3

  4. These findings support that Weaver (show KCNJ6 Antibodies) syndrome is a disorder with locus heterogeneity and can be due to pathogenic variants in either EZH2 (show EZH2 Antibodies) or EED. This case highlights the utility of exome sequencing as a clinical diagnostic tool for novel gene discovery as well as the importance of re-examination of exome data as new information about gene-disease associations becomes available.

  5. we have found two unrelated families of different ethnicities, with a similar rare phenotype, both associated with de novo mutations in this member of the PRC2 complex, we are confident that EED is indeed a novel overgrowth gene.

  6. Mutations of SUZ12 and EED are reported to have tumor suppressive functions. (Review)

  7. These results suggest that the SNPs of the EED gene might not be associated with susceptibility to CRC (show CALR Antibodies).

  8. An integral role for EED as an epigenetic exchange factor coordinating the activities of PRC1 (show PRC1 Antibodies) and 2, is reported.

  9. Data show that overall enhancer of zeste 2 (EZH2), embryonic ectoderm development (EED) and suppressor of zeste 12 homolog (SUZ12) expression in the colorectal cancer (CRC) tissues was significantly increased than in the non-cancerous tissue.

  10. EED, a component of Polycomb (show CBX2 Antibodies) repressive complex-2 (PRC2) that catalyzes methylation of lysine 27 of histone H3 (show HIST3H3 Antibodies) (H3K27), was involved in epithelial-mesenchymal transition (EMT (show ITK Antibodies)) of cancer cells induced by Transforming Growth Factor-beta (TGF-beta).

Mouse (Murine) Embryonic Ectoderm Development (EED) interaction partners

  1. Eed deficiency in chondrocytes causes severe kyphosis and a growth defect with decreased chondrocyte proliferation, accelerated hypertrophic differentiation and cell death with reduced Hif1a (show HIF1A Antibodies) expression

  2. The progenitors in Eed mutant mice that were induced to differentiate did not develop into properly formed nephrons. Lhx1 (show LHX1 Antibodies), normally expressed in the renal vesicle, was overexpressed in kidneys of Eed mutant mice. Thus, PRC2 has a crucial role in suppressing the expression of genes that maintain the progenitor state, allowing nephron differentiation to proceed.

  3. discovery of differentiation stage-specific and dose-dependent roles of EED in normal hematopoiesis and leukemogenesis

  4. our work provides in vivo evidence that the structural integrity of EED to H3K27me3 propagation is critical, especially for embryonic development and hematopoietic homeostasis, and that its perturbation increases the predisposition to hematologic malignancies

  5. Deletion of Eed but not Ezh2 (show EZH2 Antibodies) from embryonic urothelial progenitors caused premature differentiation of Krt5 (show KRT5 Antibodies)+ basal cells and ectopic expression of squamous cell markers.

  6. in the skin epithelium, EED, Suz12, and Ezh1 (show EZH1 Antibodies)/2 function largely as subunits of the PRC2 complex and have roles in skin development

  7. EED is required for proper erythropoiesis and for formation of hematopoietic progenitor and stem cells, but is dispensable for endothelial lineage commitment and early vascular patterning

  8. Genetic inactivation of Ezh2 (show EZH2 Antibodies) or Eed cooperates with NRASQ61K in leukemogenesis.

  9. EED affects the lymphoid versus myeloid decision processes within the lymphomyeloid lineage

  10. Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2a-independent mechanisms in a murine model.

Embryonic Ectoderm Development (EED) Antigen Profile

Protein Summary

This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene.

Gene names and symbols associated with EED

  • embryonic ectoderm development (eed) antibody
  • embryonic ectoderm development (EED) antibody
  • embryonic ectoderm development S homeolog (eed.S) antibody
  • microRNA 6755 (MIR6755) antibody
  • embryonic ectoderm development (Eed) antibody
  • embryonic ectoderm development L homeolog (eed.L) antibody
  • eed antibody
  • ENSMUSG00000039373 antibody
  • HEED antibody
  • l(7)5Rn antibody
  • l7Rn5 antibody
  • lusk antibody
  • psXEED antibody
  • WAIT1 antibody
  • Xeed antibody
  • Xeed-A antibody
  • Xeed-B antibody
  • zgc:112509 antibody

Protein level used designations for EED

polycomb protein eed , embryonic ectoderm development , WD protein associating with integrin cytoplasmic tails 1 , polycomb protein EED , embryonic ectoderm development protein variant 1 , polycomb protein eed-B , embryonic ectoderm development protein , lethal, Chr 7, Rinchik 5 , polycomb protein eed-A

GENE ID SPECIES
550079 Xenopus (Silurana) tropicalis
703866 Macaca mulatta
100601094 Nomascus leucogenys
8726 Homo sapiens
550463 Danio rerio
398420 Xenopus laevis
426381 Gallus gallus
404183 Bos taurus
13626 Mus musculus
293104 Rattus norvegicus
100344036 Oryctolagus cuniculus
100728793 Cavia porcellus
476779 Canis lupus familiaris
101113712 Ovis aries
734571 Xenopus laevis
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