EED antibody (AA 1-300)

Catalog No. ABIN7163806

Product Details anti-EED Antibody

Target: EED (Embryonic Ectoderm Development (EED))

Binding Specificity: AA 1-300

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EED antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Polycomb protein EED protein (1-300AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for EED

Target: EED (Embryonic Ectoderm Development (EED))

Alternative Name: EED (EED Products)

Synonyms: Xeed antibody, heed antibody, wait1 antibody, EED antibody, HEED antibody, WAIT1 antibody, zgc:112509 antibody, Xeed-B antibody, eed antibody, psXEED antibody, ENSMUSG00000039373 antibody, l(7)5Rn antibody, l7Rn5 antibody, lusk antibody, Xeed-A antibody, embryonic ectoderm development antibody, embryonic ectoderm development S homeolog antibody, microRNA 6755 antibody, embryonic ectoderm development L homeolog antibody, eed antibody, EED antibody, eed.S antibody, MIR6755 antibody, Eed antibody, eed.L antibody

Background:

Background: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates \\\'Lys-9\\\' and \\\'Lys-27\\\' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes \\\'Lys-26\\\' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 \\\'Lys-27\\\', whereas H3 \\\'Lys-27\\\' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

Aliases: eed antibody, EED protein antibody, EED, mouse, homolog of antibody, EED_HUMAN antibody, Embryonic ectoderm development antibody, Embryonic ectoderm development isoform a antibody, Embryonic ECTODERM development protein homolog antibody, Embryonic ectoderm development protein, mouse, homolog of antibody, hEED antibody, OTTHUMP00000235483 antibody, OTTHUMP00000235484 antibody, OTTHUMP00000235485 antibody, Polycomb protein eed antibody, WAIT 1 antibody, WAIT-1 antibody, WAIT1 antibody, WD protein associating with integrin cytoplasmic tails 1 antibody

UniProt: O75530