anti-Emerin (EMD) Antibodies

Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. Additionally we are shipping Emerin Kits (6) and Emerin Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EMD 2010 P50402
EMD 13726 O08579
EMD 25437 Q63190
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Top anti-Emerin Antibodies at

Showing 10 out of 109 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
Hamster Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: Emerin Antibody [NBP1-87692] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells); Lane 2: NBT-II cell lysate (Rat Wistar bladder tumour cells); Lane 3: PC12 cell lysate (Pheochromocytoma of rat adrenal medulla). Immunohistochemistry-Paraffin: Emerin Antibody [NBP1-87692] - Immunohistochemical staining of human breast shows strong nuclear membrane positivity in glandular cells. 0.1 mL Log in to see 7 to 9 Days
Human Rabbit Un-conjugated IHC (p), WB Emerin was detected in paraffin-embedded sections of human intetsinal cancer tissues using rabbit anti- Emerin Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). Emerin was detected in paraffin-embedded sections of human lung cancer tissues using rabbit anti- Emerin Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4 to 6 Days
Human Mouse Un-conjugated ELISA, FACS, ICC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using EMD mAb against human EMD (AA: 1-222) recombinant protein. (Expected MW is 51.1 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
Human Mouse Un-conjugated ELISA, FACS, ICC, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 2:Western blot analysis using EMD mAb against human EMD (AA: 1-222) recombinant protein. (Expected MW is 51.1 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
Rabbit Mouse Un-conjugated ICC, IF, WB 0.1 mL Log in to see 7 to 8 Days
Human Mouse Un-conjugated ELISA, IF, IHC, WB Immunofluorescence of monoclonal antibody to EMD on HeLa cell (antibody concentration 10 µg/mL). EMD monoclonal antibody (M01), clone 3B9 Western Blot analysis of EMD expression in HeLa. 100 μg Log in to see 8 to 11 Days
Human Rabbit Un-conjugated FACS, WB Western blot analysis of EMD antibody (C-term) (ABIN390427) in MCF-7 cell line lysates (35 µg/lane). EMD (arrow) was detected using the purified polyclonal antibody. Flow cytometric analysis of MDA-231 cells using EMD Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
Human Mouse Un-conjugated FACS, ICC, IHC (fro), IHC (p), WB Western blot analysis of Emerin using anti-Emerin antibody .   Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.    Lane 1: human Hela whole cell lysates,  Lane 2: human placenta tissue lysates,  Lane 3: human Caco-2 whole cell lysates,  Lane 4: human HepG2 whole cell lysates, Lane 5: Rabbit IgG,  Lane 6: Marker 1113,  Lane 7: human Jurkat whole cell lysates.  Lane 8: human MDA-MB-453 whole cell lysates,  Lane 9: human SK-OV-3 whole cell lysates,  Lane 10: human SW620 whole cell lysates.   After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with mouse anti-Emerin antigen affinity purified monoclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a Biotin Conjugated goat anti-mouse IgG secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1001) with Tanon 5200 system. 100 μg Log in to see 4 to 6 Days

Top referenced anti-Emerin Antibodies

  1. Hamster Polyclonal Emerin Primary Antibody for ICC, IF - ABIN4307811 : Collard, Herledan, Pincini, Guerci, Randrianarison-Huetz, Sotiropoulos: Nuclear actin and myocardin-related transcription factors control disuse muscle atrophy through regulation of Srf activity. in Journal of cell science 2014 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal Emerin Primary Antibody for IHC, ELISA - ABIN1002239 : Cai, Huang, Ghirlando, Wilson, Craigie, Clore: Solution structure of the constant region of nuclear envelope protein LAP2 reveals two LEM-domain structures: one binds BAF and the other binds DNA. in The EMBO journal 2001 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal Emerin Primary Antibody for IHC (p), WB - ABIN541293 : Chen, Engelman: The barrier-to-autointegration protein is a host factor for HIV type 1 integration. in Proceedings of the National Academy of Sciences of the United States of America 1999 (PubMed)
    Show all 3 Pubmed References

  4. Rabbit Monoclonal Emerin Primary Antibody for ICC, IF - ABIN1042591 : Manilal, Nguyen, Sewry, Morris: The Emery-Dreifuss muscular dystrophy protein, emerin, is a nuclear membrane protein. in Human molecular genetics 1996 (PubMed)

More Antibodies against Emerin Interaction Partners

Fruit Fly (Drosophila melanogaster) Emerin (EMD) interaction partners

  1. bocks is a nonessential gene; complete loss of Bocks causes no overt developmental defects

Xenopus laevis Emerin (EMD) interaction partners

  1. two forms, particularly abundant in mesodermal and neuro-ectodermal regions of the embryo

Human Emerin (EMD) interaction partners

  1. Emerin plays a crucial role in nuclear invagination and in the nuclear calcium transient in Emery-Dreifuss muscular dystrophy.

  2. evaluation of the diagnostic value of emerin and CD56 in papillary thyroid carcinoma, using immunohistochemistry

  3. the mobility of YFP-Emerin was higher in Samp1 knock out cells and lower in cells overexpressing Samp1, suggesting that Samp1 significantly attenuates the mobility of Emerin in the nuclear envelope. The mobility of Emerin depends on RanGTP. The affinity between Samp1 and Emerin is decreased in the presence of Ran, suggesting that Ran attenuates the interaction between Samp1 and Emerin.

  4. Epstein-Barr virus early lytic protein BFRF1 alters emerin distribution and post-translational modifications.

  5. results indicate that emerin negatively regulates Notch signaling by promoting the retention of the NICD at the nuclear membrane

  6. It has been concluded that the LEM domain, responsible for binding to the chromatin protein BAF, undergoes a conformational change during self-assembly of emerin N-terminal region.

  7. X-linked Emery-Dreifuss muscular dystrophy may occur along with dilative cardiomyopathy.

  8. Association of emerin with nuclear BAF in cells required the LEM domain (residues 1-47).

  9. These data suggest a new role of EMD as an enhancer of autophagosome formation in the C16-ceramide autophagy pathway in colon cancer cells.

  10. Results highlight the interactions at the nuclear envelope where mutations in the EMD and TMPO gene in combination with mutations in SUN1 have an impact on several components of the network.

  11. Emerin, a conserved LEM-domain protein, is among the few nuclear membrane proteins for which extensive basic knowledge--biochemistry, partners, functions, localizations, posttranslational regulation, roles in development and links to human disease

  12. the nucleoplasmic domains of Samp1 and Emerin can bind directly to each other.

  13. Findings show a novel EMD deletion causing rare clinical presentations which broaden the heterogeneous spectrum of phenotypes attributed to EMD mutations and provide new insight of genotype-phenotype correlations between EMD mutations and EDMD symptoms.

  14. Emerin and BAF associated only in histone- and lamin-B-containing fractions. The S173D mutation specifically and selectively reduced GFP-emerin association with BAF by 58%

  15. Immunofluorescence assay and biochemical analysis of infected or transfected cells showed that Kaposi's sarcoma-associated herpesvirus p29 expression resulted in delocalization and hyperphosphorylation of emerin.

  16. Genetic testing identified the mutation in the EMD gene, confirming X-linked recessive (XR) EDMD. The patient's asymptomatic mother was confirmed as a carrier.

  17. Data augment the number of EMD mutations by 13.8%, equating to an increase of 5.2% in the total known EMD mutations and to an increase of 6.0% in the number of different mutations.

  18. Data provide evidence that 4.1R has functional interactions with emerin and A-type lamin that impact upon nuclear architecture, centrosome-nuclear envelope association and the regulation of beta-catenin transcriptional co-activator activity.

  19. An association of Mel18 with emerin was observed in Hutchinson-Gilford progeria syndrome, but not in WT cells.

  20. BAF and emerin have dynamic roles in genome integrity and might help couple DNA damage responses to the nuclear lamina network

Mouse (Murine) Emerin (EMD) interaction partners

  1. these data indicate that Emerin, a conserved nuclear lamina protein, couples extracellular matrix mechanics and SRF-Mkl1-dependent transcription.

  2. Emerin-null progenitors were delayed in their cell cycle exit, had decreased myosin heavy chain (MyHC) expression and formed fewer myotubes. Emerin binds to and activates histone deacetylase 3 (HDAC3).

  3. changes in nuclear size and shape, which are mediated by nuclear envelope structural proteins lamin A/C and/or emerin, also impact gene regulation and lineage differentiation in early embryos.

  4. Results suggest that emerin protein is an essential component of the cellular apparatus constraining and fine-tuning Wnt/b-catenin signaling in the heart providing tight control of cardiomyocyte numbers.

  5. emerin functions with myosin IIB to polarize actin flow and nuclear movement in fibroblasts, suggesting a novel function for the nuclear envelope in organizing directional actin flow and cytoplasmic polarity.

  6. Interactions between HDAC3 and Emerin mediate the interaction of myogenic regulatory loci with the nuclear lamina.

  7. a novel mechanism that could provide insight into the disease aetiology for the cardiac phenotype in many laminopathies, whereby lamin A/C and emerin regulate gene expression through modulation of nuclear and cytoskeletal actin polymerization

  8. report significant perturbations in the expression and activation of p38/Mapk14 in emerin-null myogenic progenitors, showing that perturbed expression of Wnt, IGF-1, TGF-beta, and Notch signaling components disrupts normal downstream myogenic signaling

  9. emerin facilitates repressive chromatin formation at the nuclear periphery by increasing the catalytic activity of HDAC

  10. Perturbation to or total loss of the emerin-beta-catenin complex compromises both intercalated disc function and beta-catenin signalling in cardiomyocytes.

  11. These findings suggest roles for emerin as a downstream effector and signal integrator for tyrosine kinase signaling pathway(s) at the nuclear envelope.

  12. emerin and lamin A/C are bound to actin at the late stages of myotube differentiation

  13. the lamin a-emerin complex might have a role in muscular dystrophy and cardiomyopathy

  14. Data show that emerin-deficient mouse embryo fibroblasts have apparently normal nuclear mechanics but impaired expression of mechanosensitive genes in response to strain.

  15. Emerin deficiency causes minimal motor and cardiac dysfunctions in mice with a structural fragility of myonuclei.

  16. Altered nuclear envelope elasticity caused by loss of emerin could contribute to increased nuclear fragility in Emery-Dreifuss muscular dystrophy patients with mutations in the emerin gene.

  17. Data show that both downregulation of LUMA and overexpression of dominant-negative acting LUMA fragments causes redistribution of emerin.

  18. Knockdown of A-type lamins and emerin in HeLa and C2C12 stimulated phosphorylation and nuclear translocation of ERK as well as activation of genes encoding downstream transcription factors.

  19. Deregulation of cell signaling contributes to nuclear envelope-linked disorders and suggests that mutations in NET25 and MAN1 may cause muscle diseases.

Emerin (EMD) Antigen Profile

Protein Summary

Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the emerin gene.

Gene names and symbols associated with anti-Emerin (EMD) Antibodies

  • emerin (EMD) antibody
  • emerin (Emery-Dreifuss muscular dystrophy) (emd) antibody
  • bocksbeutel (bocks) antibody
  • emerin L homeolog (emd.L) antibody
  • emerin S homeolog (emd.S) antibody
  • emerin (emd) antibody
  • emerin (Emd) antibody
  • AW550900 antibody
  • Bocks antibody
  • Bocksbeutel antibody
  • CG9424 antibody
  • Dmel\\CG9424 antibody
  • EDMD antibody
  • emd antibody
  • emerin antibody
  • fj58f01 antibody
  • LEMD5 antibody
  • Sta antibody
  • wu:fj58f01 antibody
  • xemd1 antibody
  • xemd2 antibody
  • xemerin1 antibody
  • xemerin2 antibody

Protein level used designations for anti-Emerin (EMD) Antibodies

emerin (Emery-Dreifuss muscular dystrophy) , emerin , CG9424-PA , CG9424-PB , bocksbeutel-PA , bocksbeutel-PB , xemerin1 , xemerin2 , emerin-like , LEM domain containing 5

465938 Pan troglodytes
558212 Danio rerio
699400 Macaca mulatta
100137262 Papio anubis
100328755 Oryctolagus cuniculus
41162 Drosophila melanogaster
733232 Xenopus laevis
733233 Xenopus laevis
100127712 Xenopus (Silurana) tropicalis
100415714 Callithrix jacchus
2010 Homo sapiens
13726 Mus musculus
25437 Rattus norvegicus
399681 Bos taurus
492249 Canis lupus familiaris
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