anti-Empty Spiracles Homeobox 2 (EMX2) Antibodies

Human Empty Spiracles Homeobox 2 (EMX2) interaction partners

1. EMX2 is frequently down-regulated in human colorectal cancer, and down-regulation of EMX2 is a prognostic marker for disease-free and overall survival.

2. Emx2 is a novel promising tool for therapy of glioblastoma and prevention of its recurrences.

3. EMX2 inhibits proliferation and tumorigenesis through inactivation of the Wnt/beta-catenin pathway in CRC cells.

4. EMX2 expression was down-regulated in lung SCC tissue compared to matched adjacent normal tissue. EMX2 expression was associated with improved overall survival. Knockdown promoted chemo-resistance and cell migration.

5. Although it is uncommon (0.19%), EMX2 is the first gene identified that if perturbed may cause isolated incomplete mullerian fusion.

6. Deletions of EMX2 have been associated with a wide range of DSD.

7. EMX2 expression is downregulated in advanced cases of malignant pleural mesothelioma and may serve as an important prognostic and predictive molecular biomarker of progression-free survival.

8. downregulation of empty spiracles homeobox 2 (EMX2) was associated with tumor progression and may be a critical factor in the carcinogenesis and progression of endometrial cancer

9. EMX2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo.

10. Study analyzed mutations of EMX2 gene in 45 prostate carcinomas, 51 non-small cell lung cancers, 43 gastric carcinomas, 44 colorectal carcinomas, and 43 breast carcinomas by polymerase chain reaction and single-strand conformation polymorphism assay.

11. Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma.

12. Data show that human teneurin-1 is directly regulated by EMX2 at a conserved promoter region upstream of the transcription start site, and identify and characterize the EMX2 dependent promoter element of human teneurin-1.

13. promoter. Restoration of EMX2 expression in lung cancer cells lacking endogenous EMX2 expression suppressed cell proliferation and invasive phenotypes

14. EMX2 gene has been reported in schezencephaly (cleft brain) including epilepsy in some patients.

15. In these studies we identify and characterize the regulation of EMX2 by HOXA10.

16. Endometrial EMX2 expression is aberrant in women with endometriosis and is mediated by altered HOXA10 expression.

17. EMX2 levels in cortical progenitors of EMX2 transgenic mice disproportionately specify sizes and positions of primary cortical areas.

18. It is unlikely that the EMX2 or PTEN gene variants investigated contribute to risk for initiation and/or development of endometriosis.

19. provide results of EMX2 sequencing in 39 new schizencephaly patients, detecting no pathogenic mutations

20. These data support recent reports that EMX2 but not PAX6 is more directly involved in arealization, highlighting that analysis of human development allows better spatio-temporal resolution than studies in rodents.

Mouse (Murine) Empty Spiracles Homeobox 2 (EMX2) interaction partners

1. We found that expression of Emx2 and Lhx2 initiated between neuronal progenitor and neuronal precursor stages. As far as the sensory neurons of the vomeronasal organ are concerned, Meis1 and Meis2 were only expressed in the apical layer, together with Gnai2, but not in the basal layer.

2. Results showed that Emx2 overexpression in cortico-cerebral stem cells inhibits astrogenesis, largely in a cell-autonomous way

3. Emx2 expression led to inhibition of cell proliferation and Wnt signaling pathway both in vitro and in a gastric cancer xenograft model in vivo.

4. A high incidence of urinary tract anomalies in Pax2;Emx2 were found in compound heterozygous mice that are not found in single heterozygous mice.

5. Pbx genes share overlapping functions and Pbx1 and Emx2 genetically interact in pelvic formation.

6. These results strongly suggest that Emx2 is required for regulation of tight junction assembly and allowing migration of the gonadal epithelia to the mesenchyme, which are possibly mediated by suppression of Egfr expression.

7. detailed picture of Emx2 and Foxg1 activities in cortico-cerebral histogenesis resulted from this study

8. Emx2 expression was greatly reduced, but persisted in the telencephalon of the enhancer mutant, indicating that there exists another enhancer for Emx2 expression unique to mammalian telencephalon.

9. Scapula development is governed by genetic interactions of Pbx1 with its family members and with Emx2 via their cooperative control of Alx1

10. Emx2 and early hair cell development in the mouse inner ear are reported.

11. activation of Emx2 by a short antisense transcript may be a prototype of a method for overexpressing single specific genes, without introducing additional copies of them into the genome

12. Emx2 regulates the proliferation of stem cells of the adult mammalian central nervous system.

13. Emx2 is a direct transcriptional target of Wnt and Bmp signalling and provide insights into a genetic hierarchy involving Gli3, Emx2 and Bmp and Wnt genes in the control of dorsal telencephalic development.

14. Absence of Cajal-Retzius cells and subplate neurons associated with defects of tangential cell migration from ganglionic eminence in Emx1/2 double knockout mice

15. High expression of one functional allele of either of the homeobox genes Emx2 or Pax6 in the dorsal telencephalon is necessary and sufficient to activate morphogenesis of cerebral cortex

16. early targeting abnormality is associated with Emx2 altered expression pattern in the cortex

17. Emx2 is essential for the terminal differentiation of granular cells and the correct formation of extrinsic and intrinsic hippocampal connections

18. By using Northern analysis and in situ hybridization, we found that EMX2 is expressed in the adult urogenital tract in an inverse temporal pattern from HOXA10, suggestive of a negative regulatory relationship.

19. The more severe phenotypes in Emx double mutants suggest that Emx1 and Emx2 cooperate to regulate multiple features of cortical development.

20. Results indicate that EMX2 is a direct repressor of Wnt1 expression in the developing mammalian telencephalon.