Endoglin Proteins (ENG)

Human Endoglin (ENG) interaction partners

1. The role of CD34 (show CD34 Proteins) in determining the premalignant nature of ral (show rala Proteins) submucous fibrosis (OSF (show OSTF1 Proteins)) could not be ascertained, since all endothelial cells were positive for CD34 (show CD34 Proteins), whereas CD105 appeared to be more specific as it is associated with hypoxia-induced angiogenesis which is occurring in OSF (show OSTF1 Proteins) due to hyalinization suggesting, CD105 to be more specific marker to determine neoangiogenesis in OSF (show OSTF1 Proteins)

2. Data show that the extracellular domain of endoglin promotes specific platelet adhesion.

3. ENG mutation carriers were more likely than ACVRL1 (show ACVRL1 Proteins) mutation carriers to have pAVMs (P < 0.001) or multiple lesions (P = 0.03), and to undergo procedural intervention (P = 0.02). The HHT (show ACVRL1 Proteins) severity score was significantly higher in ENG than in ACVRL1 (show ACVRL1 Proteins) (P = 0.02).

4. levels of the angiogenesis mediators endoglin, HB-EGF (show HBEGF Proteins), BMP-9 (show GDF2 Proteins) and FGF-2 (show FGF2 Proteins) in patients with severe sepsis and septic shock; endoglin and HB-EGF (show HBEGF Proteins) could be involved in the host response of sepsis; additional studies are warrant to investigate their role as biomarker or therapeutic targets in sepsis

5. A heterozygous genetic variant, c.704dupC; p.Val236Glyfs*98, was identified in the ENG gene. The variant c.704dupC was not previously described in the HHT (show ACVRL1 Proteins) Mutations Database

6. Endoglin levels are changed after stroke.

7. we found significant correlation with CD105 and survival rate of the patient. Similar correlation was found between histological grades and TNM (show ODZ1 Proteins) staging in CD105. High expression was associated with low survival; whereas no significant correlation was found with expression of VEGF (show VEGFA Proteins) with survival, also with TNM (show ODZ1 Proteins) staging and histological grading.

8. CD105 expression was associated with more aggressive tumor behavior, more advanced disease, and worse prognosis in clear cell renal cell carcinoma (show MOK Proteins)

9. Data indicate that in pancreatic cancer cells, the expression of ENG may be controlled by a pathway mediated by SMAD4 (show SMAD4 Proteins). In addition, ENG was found to be related to the spheroid-forming ability of cells and to be involved in the invasive capacity of pancreatic cancer cells.

10. The increase in TGF-beta3 (show TGFB3 Proteins) found in inflammatory wound healing (WF) highlights its negative effect on wound healing, while the increased levels of sEng in granulating WF affects the leukocyte adhesion/transmigration through the endothelium, reducing the inflammatory response and favoring the wound healing.

Mouse (Murine) Endoglin (ENG) interaction partners

1. Transplantation of mesenchymal stem cells, when combined with endothelial progenitor cells, accelerate muscle recovery in a mouse model of hind limb ischemia, through an endoglin-dependent mechanism.

2. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments

3. Data show that concomitant activin receptor-like kinase 1 (Acvrl1 (show ACVRL1 Proteins)) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

4. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome.

5. systemic DPP4 (show DPP4 Proteins) inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart

6. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases

7. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

8. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling.

9. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

10. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.