Endoglin Proteins (ENG)

Human Endoglin (ENG) interaction partners

1. In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF (show VEGFA Proteins)-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process

2. we showed that Endoglin (CD105) expression not only demarcates a cancer stem cell subpopulation but also confers self-renewal ability and contributes to chemoresistance in RCC (show XRCC1 Proteins).

3. In patients with hypertensive disorders of pregnancy, those in the highest tertile of mean arterial pressure had the highest serum levels of sFlt1 (show FLT1 Proteins) and sEng.

4. BMP9 (show GDF2 Proteins) interacts with a hydrophobic surface of the N-terminal orphan domain of ENG, which adopts a new duplicated fold generated by circular permutation.

5. Tale of Two Endoglins: How Does Tail-Less Soluble Endoglin Deregulate Lung Development

6. The variant lies in a novel binding-site for the transcription factor Sp1 (show SP1 Proteins), known to be involved in the regulation of ENG and ACVRL1 (show ACVRL1 Proteins) transcription.

7. Mobilization of the CD44 (show CD44 Proteins)/CD105 positive synovial cells seems to play a role in the genesis of hip osteoarthritis.

8. Circulating tissue transglutaminase is associated with sFlt-1, soluble endoglin and VEGF in the maternal circulation of preeclampsia patients, suggesting that tTG may have a role in the pathogenesis of PE.

9. Gestation-adjusted sEng, sFlt-1 and PlGF (show PGF Proteins) levels were 11%, 36%, and 30%, respectively, lower in women who later suffered miscarriage compared with unaffected pregnancies

10. Nuclear survivin (show BIRC5 Proteins) expression correlates with endoglin-assessed microvascularisation in laryngeal squamous cell carcinoma.

Mouse (Murine) Endoglin (ENG) interaction partners

1. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments

2. Data show that concomitant activin receptor-like kinase 1 (Acvrl1 (show ACVRL1 Proteins)) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

3. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome.

4. systemic DPP4 (show DPP4 Proteins) inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart

5. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases

6. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

7. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling.

8. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

9. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.

10. the TGFbeta1 (show TGFB1 Proteins) coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload