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ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Antibodies (779) and Endoglin Kits (64) and many more products for this protein.
Showing 10 out of 46 products:
Human ENG Protein expressed in Wheat germ - ABIN1352793
Banerjee, Dhara, Bacanamwo: Endoglin is a novel endothelial cell specification gene. in Stem cell research 2011
Circulating tissue transglutaminase is associated with sFlt-1, soluble endoglin and VEGF in the maternal circulation of preeclampsia patients, suggesting that tTG may have a role in the pathogenesis of PE.
Gestation-adjusted sEng, sFlt-1 and PlGF (show PGF Proteins) levels were 11%, 36%, and 30%, respectively, lower in women who later suffered miscarriage compared with unaffected pregnancies
Nuclear survivin (show BIRC5 Proteins) expression correlates with endoglin-assessed microvascularisation in laryngeal squamous cell carcinoma.
Dendritic-cells loaded with lysates derived from CD105+ human renal cell carcinoma (show MOK Proteins) cancer stem cells (CSCs) induced more functionally specific active T cells and specific antibodies against CSCs, and clearly depressed the tumor growth in mice.
Report no relationship between serum endoglin levels and ovarian cancer microvessel density and tumor endoglin expression.
TGF-beta (show TGFB1 Proteins) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin was increased in both subtypes.
Study described present a series of pulmonary arterial hypertension patients with mutations in the ENG gene, some of them not previously described, exhibiting clinical and hemodynamic alterations. These results suggest the presence of these mutations may be associated with the severity of the disease.
Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG, two in BMPR1A (show BMPR1A Proteins), one in PTEN, and one in SMAD4 (show SMAD4 Proteins). Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.
9q33.3q34.11 microdeletion including ENG gene identified in four patients with intellectual disability, epilepsy, nail (show CD244 Proteins) dysplasia and bone malformations.
Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.
systemic DPP4 (show DPP4 Proteins) inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart
results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling.
Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes
the TGFbeta1 (show TGFB1 Proteins) coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload
Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.
Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.
The changes in CD90 (show THY1 Proteins) and CD105 expression in the testis and ovary of mice are reported.
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endoglin (Osler-Rendu-Weber syndrome 1)
, CD105 antigen
, cell surface MJ7/18 antigen
, transmembrane glycoprotein