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ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Antibodies (797) and Endoglin Kits (62) and many more products for this protein.
Showing 10 out of 45 products:
Human ENG Protein expressed in Wheat germ - ABIN1352793
Banerjee, Dhara, Bacanamwo: Endoglin is a novel endothelial cell specification gene. in Stem cell research 2011
Dendritic-cells loaded with lysates derived from CD105+ human renal cell carcinoma (show MOK Proteins) cancer stem cells (CSCs) induced more functionally specific active T cells and specific antibodies against CSCs, and clearly depressed the tumor growth in mice.
Report no relationship between serum endoglin levels and ovarian cancer microvessel density and tumor endoglin expression.
TGF-beta (show TGFB1 Proteins) type I, II, and III receptors were all identified in pregnant serum; all were substantially elevated in early-onset but not late-onset PE. Endoglin was increased in both subtypes.
Study described present a series of pulmonary arterial hypertension patients with mutations in the ENG gene, some of them not previously described, exhibiting clinical and hemodynamic alterations. These results suggest the presence of these mutations may be associated with the severity of the disease.
Several germline variants in Hamartomatous Polyposis Syndrome genes were detected, among them three in ENG, two in BMPR1A (show BMPR1A Proteins), one in PTEN, and one in SMAD4 (show SMAD4 Proteins). Although some of the detected variants have been reported previously none could be definitely pathogenic or likely pathogenic.
9q33.3q34.11 microdeletion including ENG gene identified in four patients with intellectual disability, epilepsy, nail (show CD244 Proteins) dysplasia and bone malformations.
Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.
Soluble endoglin did not vary over the pregnancy course or between gestational hypertension, preeclampsia, and control groups.
Serum and placental LXR-alpha (show NR1H3 Proteins) and endoglin levels were significantly higher in patients with preeclampsia than those in control group (P<0.05, each).
Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (show TGFB1 Proteins)/Smad2 (show SMAD2 Proteins) signaling pathway, but not Smad1 (show GARS Proteins)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.
Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling.
Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes
the TGFbeta1 (show TGFB1 Proteins) coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload
Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size.
Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction.
The changes in CD90 (show THY1 Proteins) and CD105 expression in the testis and ovary of mice are reported.
the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients.
These results demonstrate a requirement for endoglin in descendants of Pax3 (show PAX3 Proteins)-expressing vascular cell precursors.
This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
endoglin (Osler-Rendu-Weber syndrome 1)
, CD105 antigen
, cell surface MJ7/18 antigen
, transmembrane glycoprotein