Endoglin Proteins (ENG)

ENG encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. Additionally we are shipping Endoglin Antibodies (765) and Endoglin Kits (74) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ENG 2022 P17813
ENG 13805 Q63961
ENG 497010  
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Top Endoglin Proteins at antibodies-online.com

Showing 10 out of 53 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human Fc Tag 50 μg Log in to see 14 to 16 Days
Human Cells Mouse His tag 100 μg Log in to see 20 to 21 Days
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
Human Cells Human His tag 50 μg Log in to see 20 to 21 Days
Escherichia coli (E. coli) Human His tag,TRX tag   50 μg Log in to see 4 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
Baculovirus infected Insect Cells Mouse His tag 100 μg Log in to see 13 to 16 Days
Escherichia coli (E. coli) Human His tag 100 μg Log in to see 13 to 16 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

ENG Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
, , , , , ,
Mouse (Murine) , , , ,
Rat (Rattus)

Top referenced Endoglin Proteins

  1. Human ENG Protein expressed in Wheat germ - ABIN1352793 : Banerjee, Dhara, Bacanamwo: Endoglin is a novel endothelial cell specification gene. in Stem cell research 2011 (PubMed)

More Proteins for Endoglin (ENG) Interaction Partners

Human Endoglin (ENG) interaction partners

  1. The role of CD34 (show CD34 Proteins) in determining the premalignant nature of ral (show rala Proteins) submucous fibrosis (OSF (show OSTF1 Proteins)) could not be ascertained, since all endothelial cells were positive for CD34 (show CD34 Proteins), whereas CD105 appeared to be more specific as it is associated with hypoxia-induced angiogenesis which is occurring in OSF (show OSTF1 Proteins) due to hyalinization suggesting, CD105 to be more specific marker to determine neoangiogenesis in OSF (show OSTF1 Proteins)

  2. Data show that the extracellular domain of endoglin promotes specific platelet adhesion.

  3. ENG mutation carriers were more likely than ACVRL1 (show ACVRL1 Proteins) mutation carriers to have pAVMs (P < 0.001) or multiple lesions (P = 0.03), and to undergo procedural intervention (P = 0.02). The HHT (show ACVRL1 Proteins) severity score was significantly higher in ENG than in ACVRL1 (show ACVRL1 Proteins) (P = 0.02).

  4. levels of the angiogenesis mediators endoglin, HB-EGF (show HBEGF Proteins), BMP-9 (show GDF2 Proteins) and FGF-2 (show FGF2 Proteins) in patients with severe sepsis and septic shock; endoglin and HB-EGF (show HBEGF Proteins) could be involved in the host response of sepsis; additional studies are warrant to investigate their role as biomarker or therapeutic targets in sepsis

  5. A heterozygous genetic variant, c.704dupC; p.Val236Glyfs*98, was identified in the ENG gene. The variant c.704dupC was not previously described in the HHT (show ACVRL1 Proteins) Mutations Database

  6. Endoglin levels are changed after stroke.

  7. we found significant correlation with CD105 and survival rate of the patient. Similar correlation was found between histological grades and TNM (show ODZ1 Proteins) staging in CD105. High expression was associated with low survival; whereas no significant correlation was found with expression of VEGF (show VEGFA Proteins) with survival, also with TNM (show ODZ1 Proteins) staging and histological grading.

  8. CD105 expression was associated with more aggressive tumor behavior, more advanced disease, and worse prognosis in clear cell renal cell carcinoma (show MOK Proteins)

  9. Data indicate that in pancreatic cancer cells, the expression of ENG may be controlled by a pathway mediated by SMAD4 (show SMAD4 Proteins). In addition, ENG was found to be related to the spheroid-forming ability of cells and to be involved in the invasive capacity of pancreatic cancer cells.

  10. The increase in TGF-beta3 (show TGFB3 Proteins) found in inflammatory wound healing (WF) highlights its negative effect on wound healing, while the increased levels of sEng in granulating WF affects the leukocyte adhesion/transmigration through the endothelium, reducing the inflammatory response and favoring the wound healing.

Mouse (Murine) Endoglin (ENG) interaction partners

  1. Transplantation of mesenchymal stem cells, when combined with endothelial progenitor cells, accelerate muscle recovery in a mouse model of hind limb ischemia, through an endoglin-dependent mechanism.

  2. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments

  3. Data show that concomitant activin receptor-like kinase 1 (Acvrl1 (show ACVRL1 Proteins)) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

  4. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome.

  5. systemic DPP4 (show DPP4 Proteins) inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart

  6. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases

  7. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

  8. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling.

  9. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

  10. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.

Endoglin (ENG) Protein Profile

Protein Summary

This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds TGFB1 and TGFB3 with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Endoglin Proteins (ENG)

  • endoglin (ENG)
  • endoglin (Eng)
  • AI528660 protein
  • AI662476 protein
  • CD105 protein
  • DKFZp469D0419 protein
  • END protein
  • ENG protein
  • HHT1 protein
  • MGC137842 protein
  • ORW1 protein
  • S-endoglin protein

Protein level used designations for Endoglin Proteins (ENG)

endoglin (Osler-Rendu-Weber syndrome 1) , endoglin , endoglin-like , CD105 antigen , cell surface MJ7/18 antigen , transmembrane glycoprotein

609166 Canis lupus familiaris
615844 Bos taurus
741046 Pan troglodytes
771557 Gallus gallus
100173392 Pongo abelii
100226246 Taeniopygia guttata
100357448 Oryctolagus cuniculus
100387791 Callithrix jacchus
397096 Sus scrofa
2022 Homo sapiens
13805 Mus musculus
497010 Rattus norvegicus
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