Endoglin Proteins (ENG)

Human Endoglin (ENG) interaction partners

1. Endoglin levels are changed after stroke.

2. we found significant correlation with CD105 and survival rate of the patient. Similar correlation was found between histological grades and TNM (show ODZ1 Proteins) staging in CD105. High expression was associated with low survival; whereas no significant correlation was found with expression of VEGF (show VEGFA Proteins) with survival, also with TNM (show ODZ1 Proteins) staging and histological grading.

3. CD105 expression was associated with more aggressive tumor behavior, more advanced disease, and worse prognosis in clear cell renal cell carcinoma (show MOK Proteins)

4. Data indicate that in pancreatic cancer cells, the expression of ENG may be controlled by a pathway mediated by SMAD4 (show SMAD4 Proteins). In addition, ENG was found to be related to the spheroid-forming ability of cells and to be involved in the invasive capacity of pancreatic cancer cells.

5. The increase in TGF-beta3 (show TGFB3 Proteins) found in inflammatory wound healing (WF) highlights its negative effect on wound healing, while the increased levels of sEng in granulating WF affects the leukocyte adhesion/transmigration through the endothelium, reducing the inflammatory response and favoring the wound healing.

6. Soluble endoglin level could serve as a determinant of walking abilities change after supervised treadmill training program in patients with peripheral artery disease.

7. In primary hip OA, angiogenesis may be induced by a combined mechanism: hypoxia-related VEGF (show VEGFA Proteins)-dependent vasculogenesis and endothelial differentiation of the activated pluripotent cells, which are released from the hyperplastic synovial cells layer. An endothelial mesenchymal transition is assumed to be involved in the fibrotic process

8. we showed that Endoglin (CD105) expression not only demarcates a cancer stem cell subpopulation but also confers self-renewal ability and contributes to chemoresistance in RCC (show XRCC1 Proteins).

9. In patients with hypertensive disorders of pregnancy, those in the highest tertile of mean arterial pressure had the highest serum levels of sFlt1 (show FLT1 Proteins) and sEng.

10. BMP9 (show GDF2 Proteins) interacts with a hydrophobic surface of the N-terminal orphan domain of ENG, which adopts a new duplicated fold generated by circular permutation.

Mouse (Murine) Endoglin (ENG) interaction partners

1. Transplantation of mesenchymal stem cells, when combined with endothelial progenitor cells, accelerate muscle recovery in a mouse model of hind limb ischemia, through an endoglin-dependent mechanism.

2. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments

3. Data show that concomitant activin receptor-like kinase 1 (Acvrl1 (show ACVRL1 Proteins)) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume.

4. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome.

5. systemic DPP4 (show DPP4 Proteins) inhibition restores the impaired mononuclear cell homing in Eng+/- animals post-myocardial infarction, and enhances cardiac repair, which might be explained by restoring the balance between the inflammatory and regenerative macrophages present in the heart

6. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases

7. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

8. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 (show KDR Proteins) signalling.

9. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

10. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis.