anti-Engrailed Homeobox 2 (EN2) Antibodies

Mouse (Murine) Engrailed Homeobox 2 (EN2) interaction partners

1. En2 knock-out mice show impaired GABAergic neuron cell differentiation in the basal ganglia.

2. This study demonstrated that Ketogenic diet exposure during the juvenile period increases social behaviors and forebrain neural activation in adult Engrailed 2 null mice.

3. Study showed that BDNF signaling through its low-affinity receptor p75 is compromised in the forebrain of En2-/- mice; BDNF signaling deficits might be involved in the neurodevelopmental alterations observed in the En2-/- forebrain

4. En2 deletion reduces monoamine innervation of target forebrain structures, affecting forebrain structural growth, postnatal neurogenesis and related behavior.

5. confirm the early neurotransmitter deficit with a late compensatory recovery in En2 KO-mice further suggesting that this experimental animal may be considered a good predictive model for the human disease

6. The homeoprotein Engrailed is not only a survival factor for mesencephalic dopaminergic (mDA) neurons during development, but continues to exert neuroprotective and physiological functions in adult mDA neurons. [Review]

7. En2-/- hippocampus, neurofibromin-dependent pathways converging on SynI phosphorylation might underlie hippocampal-dependent learning deficits observed in En2-/- mice.

8. This study demonistrated that engrailed 2 knock-out mice show impaired spatial learning with hippocampal dysreulation.

9. EN2 levels are increased in affected individuals with an A-C/G-T genotype, supporting EN2 as an autism spectrum disorder susceptibility gene.

10. This study showed that the Engrailed proteins are present in postnatal GABAergic neurons of the mouse hippocampus and cerebral cortex, and adult En2(-/-) mice show reduced expression of GABAergic marker mRNAs in these areas.

11. En1 is the predominant functional En paralog in maturing 5-HT neurons, although a small contribution from En2 was reproducibly detected

12. En1 and En2 act together in multiple cerebellar cell types to determine overall growth and formation of particular fissures.

13. This study characterized En1 and En2 expression around birth and at postnatal day (P) 21 during the period when the cerebellum undergoes a remarkable transformation from a smooth ovoid structure to a highly foliated structure.

14. The data of this study suggested that in En2-/- mice nigrostriatal degeneration in the substantia nigra is functionally

15. genes are fundamental to patterning cerebellum foliation throughout the mediolateral axis and act late in development

16. En-2 is expressed in mandibular arch myoblasts of the mouse. The activity of the En-2 enhancer is maintained in several functionally related muscles that arise from the first arch

17. Physiological downregulation of En-2 around the day of birth in normal Purkinje cells (PCs) is critical for the timing of distinct steps of PC differentiation.

18. En2(-/-) mice display behavioral and neurochemical changes, in addition to genetic and neuropathological changes, relevant to autism spectrum disorder

19. Viable and fertile mice, heterozygous null for Engrailed-1 and homozygous null for Engrailed-2 (En1+/-;En2-/-), have an adult phenotype that resembles key pathological features of Parkinson's disease.

20. The En2 knock-out mouse harbors cerebellar abnormalities that are similar to those found in autistic individuals and has a distinct anterior shift in the position of the amygdala in the cerebral cortex.

Human Engrailed Homeobox 2 (EN2) interaction partners

1. The EN2 transcription factor is a novel ovarian cancer biomarker. It demonstrates prognostic value, correlating with worse Overall Survival and Progression-free Survival.

2. we confirmed that engrailed-2 is the target of hsa-miR-27b in human cytomegalovirus-infected glioma cells

3. The critical role of miR212 in inhibiting prostate tumor growth was verified in xenograft models of prostate cancer. These findings highlighted the role of miR212 in PCa progression. More importantly, we speculate that EN-2 is a direct target gene of miR212.

4. We identified a novel heterozygous missense variant (c.425C>G, p.Pro142Arg) in the Engrailed 2 (EN2) gene in two patients. The G variant has never been reported in public databases and was absent in 100 Thai patients with ASD and 435 Thai controls. A case-control study showed that the G allele of c.425C>G was significantly associated with ASD

5. EN2 is negatively regulated by miR-605, and down-regulation of miR-605 promotes the proliferation and invasion of prostate cancer (PCa) cells by up-regulating EN2, which leads to PCa development and progression

6. Our data suggest that the functional interaction of miR-33a and EN-2 is involved in tumorigenesis of prostate cancer

7. the results demonstrated that EN2 might play an anti-oncogenic role in oncogenesis and development of CCRCC, thereby maintaining the normal growth of human renal tubular epithelial cells.

8. EN2 may be a candidate oncogene in bladder cancer by activating the PI3K/Akt pathway and inhibiting PTEN.

9. Engrailed-2 (EN-2) is a developmentally regulated homeobox gene that is essential for Purkinje cell maturation and normal cerebellar development and patterning.

10. The mean EN2 levels in prostate cancer patients were 3.76-fold higher than those in non-prostate patients after prostate massage.

11. The exact role of EN2 expression in renal carcinoma carcinogenesis requires further investigation.

12. En2 identified as a new regulator of T-cell differentiation whose disruption induces a malignant T-cell fate in chronic myelogenous leukemia progression.

13. Two patients with underdeveloped arcuate fasciculus had novel, nonsynonymous variants in MID1 and EN2 genes regulating axon guidance pathway.

14. EN2 levels are increased in affected individuals with an A-C/G-T genotype, supporting EN2 as an autism spectrum disorder susceptibility gene.

15. urinary EN2 has the potential to be a more sensitive and specific protein biomarker for non-muscle-invasive bladder cancer than currently available tests.

16. Urinary EN2 may be useful as a non-invasive early biomarker for prostate cancer detection in genetically high-risk individuals

17. Normal EN-2 downregulation may not occur in some individuals with autism, such that the postnatal persistence of EN-2 overexpression may contribute to autism cerebellar abnormalities.

18. The data demonstrates that the autism spectrum disorder-associated A-C intronic haplotype of the ENGRAILED2 gene is a transcriptional activator, and both CUX1 and NFIB mediate this activity.

19. The WNT2 gene and EN2 gene may act in concert to influence the language development in autism.

20. findings show EN2 was expressed and secreted by prostate cancer (PC) cell lines and PC tissue but not by normal prostate tissue or stroma; presence of EN2 in urine was highly predictive of PC