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Cytotoxin and helminthotoxin with ribonuclease activity. Additionally we are shipping Eosinophil Cationic Protein Antibodies (75) and Eosinophil Cationic Protein Kits (42) and many more products for this protein.
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Testing spatial memory and hippocampal long-term potentiation revealed an impairment in APP (show APP Proteins)/PS1 (show PSEN1 Proteins) Ear2 (show NR2F6 Proteins)(-/-) mice, whereas APP (show APP Proteins)/PS1 (show PSEN1 Proteins) or Ear2 (show NR2F6 Proteins)(-/-) mice showed only minor changes.
this suggests that ECP can activate a canonical Wnt/b-catenin signaling pathway by enhancing the stabilization of b-catenin during cardiomyocyte differentiation.
Ear2 (show NR2F6 Proteins) ligand binding domain is required for Rasd1 (show RASD1 Proteins) to alleviate Ear2 (show NR2F6 Proteins)-mediated repression of renin (show REN Proteins) transcription.
was selectively chemotactic for dendritic cells; induced the activation of p42 (show EPB42 Proteins)/44 MAPK (show MAPK1 Proteins) in DCs
decreased expression of total mEar2 mRNA and protein in lung tissue and a corresponding fivefold drop in ribonuclease activity in BALF in pneumovirus infection of mice
EDN can activate myeloid DCs by triggering the Toll-like receptor (TLR)2-myeloid differentiation factor 88 signaling pathway
measuring serum ECP levels is helpful for assessing the efficacy of inhaled corticosteroids therapy in bronchial asthma children.
Data suggest that radioactive I(131) therapy leads to down-regulation of secretion of ECP from Th2 cells (helper-inducer T-lymphocytes) in post-thyroidectomy patients treated for differentiated thyroid cancer; in this study, ECP levels in serum were analyzed before, 3 days after, and 7 days after radiotherapy with I(131).
our data add new insights into the pathophysiology of AD, suggesting that BDNF (show BDNF Proteins) which correlates with disease severity and ECP levels contributes to the regulation of inflammation in an eosinophil-, but not Th2-dependent manner.
High circulating levels of eosinophil cationic protein are associated with increased incidence of ischemic stroke.
Studies mapped the structural determinants required for the eosinophil cationic protein (ECP)-bacterial lipopolysaccharide (LPS (show IRF6 Proteins)) interaction by nuclear magnetic resonance.
Increased MRP8/14 levels suggest the instability of the atherosclerotic plaque. ECP reflects the severity of coronary arteries stenosis, predicting atherosclerosis burden. They may become the new biomarkers of CAD.
Children in the acute-phase group showed higher ECP mRNA expression level than those in the stable-phase and healthy control groups, while the level in the stable-phase was markedly higher than that in the healthy control group.
drug eluting stent polymers increase eosinophil cationic protein levels following percutaneous coronary intervention independently of C-reactive protein (show CRP Proteins)
Around half of all variance in serum ECP is explained by genetic factors. Serum ECP is influenced by sex, BMI, and airway responsiveness. Serum ECP and airway responsiveness seem not to share genetic variance.
eosinophil cationic protein levels can be used to diagnosis atopic dermatitis but cannot distinguish between intrinsic and extrinsic disease.
Cytotoxin and helminthotoxin with ribonuclease activity. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
, RNase 3
, eosinophil cationic protein
, eosinophil secondary granule ribonuclease 11
, eosinophil-associated ribonuclease
, ribonuclease 1
, ribonuclease 3
, ribonuclease 7
, RNase 3-2
, eosinophil cationic protein 2
, eosinophil secondary granule ribonuclease 2
, eosinophil-associated ribonuclease 13
, eosinophil-associated ribonuclease 2
, eosinophil-derived neurotoxin, liver
, ribonuclease 3-2
, cytotoxic ribonuclease
, ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)