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EPX is a member of the peroxidase gene family and is expressed in eosinophils. Additionally we are shipping EPX Kits (24) and EPX Proteins (12) and many more products for this protein.
Showing 10 out of 71 products:
tyrosine phosphorylation of PMR1 (show ATP2C1 Antibodies) is required for the targeting and degradation of polyribosome-bound substrate mRNA
peroxidase enzymes, like MPO (show MPO Antibodies) and EPO (show EPO Antibodies), may play a fundamental role in inhibiting RANKL (show TNFSF11 Antibodies)-induced osteoclast differentiation at inflammatory sites of bone fracture and injury.
Both MPO (show MPO Antibodies) and EPO (show EPO Antibodies) are causatively involved in breast cancer progression and identified as potential therapeutic targets whereby specific novel inhibitors may reduce tumor growth and limit the occurrence of metastasis.
The main significance of this work is the discovery of EPO (show EPO Antibodies) as a novel ligand for the HER2 (show ERBB2 Antibodies) receptor. Following HER2 (show ERBB2 Antibodies) activation, EPO (show EPO Antibodies) induces activation of FAK (show PTK2 Antibodies) and subsequent activation of beta1-integrin, via inside-out signaling. This complex results in downstream activation of ERK1/2 and a sustained up regulation of both MUC4 (show MUC4 Antibodies) and the HER2 (show ERBB2 Antibodies) receptor
EPO (show EPO Antibodies)-mediated protein carbamylation is promoted during allergen-induced asthma exacerbation, and can both modulate immune responses and trigger a cascade of many of the inflammatory signals present in asthma.
there is a strong association in a given patient between both nasal and pharyngeal EPX levels and the eosinophil percentage of induced sputum.
Myeloperoxidase (show MPO Antibodies) and eosinophil peroxidase are readily internalized by HUVEC cells where they promote cellular proliferation, migration, invasion, and stimulate angiogenesis both in vitro and in vivo.
A preferential role of EPO (show EPO Antibodies) signaling via a specific surface receptor that leads to neural plasticity.
Eosinophil peroxidase in sputum represents a unique biomarker of airway eosinophilia.
report the prevalence of a common SNP in the eosinophil protein x/eosinophil-derived neurotoxin (show RNASE2 Antibodies) (EPX/EDN (show RNASE2 Antibodies), RNase2 (show RNASE2 Antibodies)) and the association with the cellular contents of EPX/EDN (show RNASE2 Antibodies) and ECP (show ECP Antibodies)
Polymorphisms of EPX and ECP (show ECP Antibodies) are associated to inflammatory bowel disease in an age and gender dependent manne.
The expression of MBP-1 and EPX was also required for induced lung expression of IL-4 (show IL4 Antibodies)/IL-13 (show IL13 Antibodies) in each setting and, in turn, the induced pulmonary remodeling events and lung dysfunction.
The absence of MBP-1 and EPX promoted a concomitant loss of eosinophil lineage-committed progenitors in the marrow, identifying a specific blockade in eosinophilopoiesis as the causative event.
HER2 (show ERBB2 Antibodies) was identified as a novel mediator of eosinophil peroxidase signaling. Eosinophil peroxidase, at noncytotoxic levels, can drive cell-cycle progression and proliferation.
Host protection against Brugia pahangi infections was unimpaired in mice deficient in eosinophil peroxidase.
Mice deficient for either eosinophil peroxidase or major basic protein on the 129/SvJ background developed significantly higher worm burdens than wild-type mice.
post-translational tyrosine nitration of eosinophil granule toxins mediated by eosinophil peroxidase
The activities of EPO (show EPO Antibodies), an eosinophilic secondary granule protein, do not affect the development of allergic pulmonary pathologies in the mouse lung at levels comparable to those observed in humans with asthma.
This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded precursor protein is processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a cluster of three peroxidase genes at chromosome 17q23. Mutations in this gene result in eosinophil peroxidase deficiency.
, polysomal ribonuclease 1
, eosinophil peroxidase-like