anti-Epithelial Cell Adhesion Molecule (EPCAM) Antibodies

EPCAM encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. Additionally we are shipping EPCAM Kits (53) and EPCAM Proteins (52) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
EPCAM 4072 P16422
EPCAM 17075 Q99JW5
EPCAM 171577 O55159
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Top anti-EPCAM Antibodies at antibodies-online.com

Showing 10 out of 1454 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, FACS, IHC (p), WB EPCAM was detected in paraffin-embedded sections of human intestinal cancer tissues using rabbit anti- EPCAM Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 ??g/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). EPCAM was detected in paraffin-embedded sections of human prostatic cancer tissues using rabbit anti- EPCAM Antigen Affinity purified polyclonal antibody (Catalog # ) at 1 µg/mL. The immunohistochemical section was developed using SABC method (Catalog # SA1022). 100 μg Log in to see 4 to 6 Days
$280.00
Details
Human Mouse Un-conjugated CyTOF, ELISA, FACS, ICC, IF, IHC, IHC (p), WB Flow Cytometry: EpCAM/CD326 Antibody (AUA1) [ABIN153141] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HeLa (B) cells using EpCAM/CD326 antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used. Western Blot: EpCAM/CD326 Antibody (AUA1) [ABIN153141] - Western blot analysis of A431 lysate (A) and Hek293 lysate (B) using EpCAM/CD326 antibody (AUA1) at 2 ug/ml. Non-reduced lysate was used in each lane. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Human Mouse Un-conjugated IF, IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Mouse FITC IHC (fro), IF, IHC (p)   0.25 mL Log in to see 6 to 8 Days
$555.50
Details
Human Mouse Un-conjugated ELISA, FACS, ICC, IF, IHC (fro), IHC (p), IP, WB Flow Cytometry: EpCAM/TROP1 Antibody (VU-1D9) [NBP2-33051] - Analysis using Azide and BSA Free version of NBP2-33051. Surface staining of HT29 cells using Ep-CAM MAb (VU-1D9) (red) and isotype control antibody (green). Immunohistochemistry-Paraffin: EpCAM/TROP1 Antibody (VU-1D9) [NBP2-33051] - Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with Ep-CAM monoclonal antibody (VU-1D9). 0.1 mg Log in to see 7 to 9 Days
$446.35
Details
Human Mouse Un-conjugated ICC, IHC, WB ABIN6383801 to EpCAM was successfully used to stain cellular membranes in human colorectal and hepatocellular carcinoma sections. Recommended concentration: 0.3-1ug/ml; Formaldehyde-fixed, paraffin-embedded human hepatocellular carcinoma stained with EpCAM Mouse Monoclonal Antibody ABIN6383801 at 0.5-1ug/ml for 30 minutes at RT. Epitope retrieval: Boiling at pH6 for 10-20 min followed by 20 min cooling. DAB staining by HRP polymer. ABIN6383801 to EpCAM was successfully used to stain cellular membranes in human colorectal and hepatocellular carcinoma sections. Recommended concentration: 0.3-1ug/ml; 100 μg Log in to see 11 to 12 Days
$563.61
Details
Human Mouse Un-conjugated IHC (fro), IHC (p), WB   0.1 mg Log in to see 6 to 8 Days
$1,149.50
Details
Human Mouse Un-conjugated ELISA, FACS, IHC, WB Black line: Control Antigen (100 ng);Purple line: Antigen(10ng);Blue line: Antigen (50 ng);Red line: Antigen (100 ng); Dilution: 1/10000 Figure 1: Western blot analysis using EPCAM mAb against human EPCAM (AA: 24-265) recombinant protein. (Expected MW is 53.4 kDa) Dilution: 1/500 - 1/2000 100 μL Log in to see 8 to 11 Days
$577.50
Details
Human Mouse Un-conjugated IHC, IHC (p), WB 100 μL Log in to see 11 to 14 Days
$507.83
Details
Human Rabbit Un-conjugated IP, WB Western blot analysis of CD326 expression in A431 (A), SW480 (B), HepG2 (C), Caco2 (D) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details

Top referenced anti-EPCAM Antibodies

  1. Human Polyclonal EPCAM Primary Antibody for ELISA (Detection), FACS - ABIN4899808 : Zhou, Wang, Chen, Tan, Qiu, Chen, Jing, Yu, Liang, Ye, Tu: Increased expression of long-noncoding RNA ZFAS1 is associated with epithelial-mesenchymal transition of gastric cancer. in Aging 2016 (PubMed)
    Show all 11 Pubmed References

  2. Mouse (Murine) Monoclonal EPCAM Primary Antibody for IHC (fro), FACS - ABIN2689192 : Basak, Speicher, Eck, Wunner, Maul, Simmons, Herlyn: Colorectal carcinoma invasion inhibition by CO17-1A/GA733 antigen and its murine homologue. in Journal of the National Cancer Institute 1998 (PubMed)
    Show all 9 Pubmed References

  3. Human Monoclonal EPCAM Primary Antibody for CyTOF, ELISA - ABIN153141 : Jordinson, El-Hariry, Calnan, Calam, Pignatelli: Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells. in Gut 1999 (PubMed)
    Show all 8 Pubmed References

  4. Human Monoclonal EPCAM Primary Antibody for ICC, FACS - ABIN349703 : Edwards, Grzyb, Dressler, Mansel, Zava, Sledge, McGuire: Monoclonal antibody identification and characterization of a Mr 43,000 membrane glycoprotein associated with human breast cancer. in Cancer research 1986 (PubMed)
    Show all 8 Pubmed References

  5. Human Monoclonal EPCAM Primary Antibody for FACS, IF - ABIN614761 : Litvinov, Velders, Bakker, Fleuren, Warnaar: Ep-CAM: a human epithelial antigen is a homophilic cell-cell adhesion molecule. in The Journal of cell biology 1994 (PubMed)
    Show all 7 Pubmed References

  6. Mouse (Murine) Monoclonal EPCAM Primary Antibody for ICC, IHC (fro) - ABIN920546 : Lee, Sharrow, Farr, Singer, Udey: Expression of the homotypic adhesion molecule E-cadherin by immature murine thymocytes and thymic epithelial cells. in Journal of immunology (Baltimore, Md. : 1950) 1994 (PubMed)
    Show all 6 Pubmed References

  7. Human Polyclonal EPCAM Primary Antibody for CyTOF, FACS - ABIN4900552 : Hsu, Osmulski, Wang, Huang, Liu, Ruan, Jin, Kirma, Gaczynska, Huang: EpCAM-Regulated Transcription Exerts Influences on Nanomechanical Properties of Endometrial Cancer Cells That Promote Epithelial-to-Mesenchymal Transition. in Cancer research 2016 (PubMed)
    Show all 5 Pubmed References

  8. Human Monoclonal EPCAM Primary Antibody for FACS, ICC - ABIN457357 : Ogura, Senzaki, Yoshizawa, Hioki, Tsubura: Immunohistochemical localization of epithelial glycoprotein EGP-2 and carcinoembryonic antigen in normal colonic mucosa and colorectal tumors. in Anticancer research 1999 (PubMed)
    Show all 5 Pubmed References

  9. Human Monoclonal EPCAM Primary Antibody for FACS, ICC - ABIN457379 : Brunner, Prelog, Verdorfer, Tzankov, Mikuz, Ensinger: EpCAM is predominantly expressed in high grade and advanced stage urothelial carcinoma of the bladder. in Journal of clinical pathology 2008 (PubMed)
    Show all 5 Pubmed References

  10. Human Monoclonal EPCAM Primary Antibody for ELISA, FACS - ABIN4308408 : Li, Passebosc-Faure, Lambert, Gentil-Perret, Blanc, Oosterwijk, Mosnier, Genin, Tostain: Flow cytometric analysis of antigen expression in malignant and normal renal cells. in Anticancer research 2000 (PubMed)
    Show all 5 Pubmed References

More Antibodies against EPCAM Interaction Partners

Human Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. This study demonstrated a new approach using a combination of EpCAM and FRalpha as CTC-capture targets to increase the sensitivity of CTC detection in NSCLC efficiently, specifically, and quickly.

  2. Functions of EpCAM in physiological processes and diseases (Review).

  3. Our results suggest that GA733-2-Fc conjugated to ER-retention motif KDEL is a more efficient antigen to prevent tumor growth induced by colorectal carcinoma and minimize an allergic response.

  4. extracellular vesicles tend to localize in the intestinal tract associated with epithelial cell adhesion molecule

  5. Overexpression of EpCAM and melan-A is associated with malignant melanoma.

  6. Quercetin suppressed breast cancer stem cell proliferation, self-renewal, and invasiveness. It also lowered the expression levels of proteins related to tumorigenesis and cancer progression, such as aldehyde dehydrogenase 1A1, C-X-C chemokine receptor type 4, mucin 1, and epithelial cell adhesion molecules.

  7. Adenocarcinomas showed significantly higher staining scores of both VEGF and alphaSMA than squamous cell carcinomas did. In 42 cases of high CD31 score, five-year survival rate (87%) of patients with lung cancer showing mature tumor vessels was significantly better than that (69%) of patients with immature tumor vessels

  8. New EPCAM founder deletion causing Lynch Syndrome has been described in Polish population.

  9. The novel and updated insights in the EpCAM field by simplifying the understanding of the biological role of this fascinating molecule, and by showing the promising therapeutic tools that have been developed by various approaches which use antibodies and vaccines for different cancer types for the clear purpose of improving patient outcome. [review]

  10. This is the first demonstration that the low sensitivity of CellSearch(R) to detect circulating tumor cells in colorectal cancer patients is not due to the lack of EpCAM

  11. Findings indicate that epithelial cell adhesion molecule (EpCAM) can be used as an additional distinction-marker for cystic lesions of the sellar region.

  12. Data indicate that epithelial cell adhesion molecule (EpCAM) show high tumor distinctiveness.

  13. After running the algorithm on two data sets [triple-negative breast cancer, (TNBC), and estrogen receptor-negative breast cancer, (ERNBC)], we conclude that EpCAM and beta1 integrin are enough to accurately predict TNBC stage, being ALDH1, CD24, CD61, and CK5 the necessary markers to exactly predict ERNBC stage.

  14. Low expressions of Oct4-EpCAM in IHC and CD133 in qPCR may reveal roles in gastric cancer

  15. EpCAM expression contributes to tumor resistance to chemotherapy in patients with ovarian cancer.

  16. The present findings suggest that Ep-CAM expression may be associated with CRC carcinogenesis, while the loss of Ep-CAM expression is correlated with the progression, metastasis, and poor prognosis of CRC. Ep-CAM expression may be a useful biomarker for the clinical diagnosis of CRC.

  17. the present study identified a positive correlation between EpCAM and COX-2 expression in breast cancer cell lines and tissue specimens. EpCAM and COX-2 were associated with the prognosis of breast cancer patients.

  18. CD133+ cells were genetically heterogeneous among patients without any defined profile compared to CD133-/EpCAM+ cells.

  19. Combining the targets E-cadherin, epithelial membrane antigen (EMA), human epidermal growth receptor type 2 (Her2/neu), carcinoembryonic antigen (CEA) resulted in nearly 100% detection of ductal ovarian metastases, whereas the combination of EMA, Her2/neu and epithelial cell adhesion molecule (EpCAM) was most suitable to detect lobular ovarian metastases.

  20. Whole-genome sequencing identified the homozygous intronic variant EPCAM c.556-14A>G, considered explanatory for the patient's intractable diarrhea and providing a diagnosis of congenital tufting enteropathy.

Pig (Porcine) Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. Ep-CAM may act as a physical homophilic interaction molecule between IELs and IECs at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection [Ep-CAM]

Zebrafish Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. Gene ontology analysis revealed that EpCAM controls various developmental programs, including uretric bud development, morphogenesis of branching epithelium, regulation of cell differentiation and cilium morphogenesis.

  2. Heterogeneously expressed in migrating cells of zebrafish lateral line

  3. EpCAM acts as a partner of E-cadherin to control adhesiveness and integrity as well as plasticity and morphogenesis within simple epithelia

Xenopus laevis Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. identification of EpCAM in a gain-of-function screen for inducers of abnormal tissue mixing during gastrulation

Mouse (Murine) Epithelial Cell Adhesion Molecule (EPCAM) interaction partners

  1. The expression of Epcam mRNA, which is a functional marker of potential hepatic stem-like cells, was controlled by LEF1, which was regulated by CLOCK.

  2. EpEX/EpCAM are sufficient to reprogram fibroblasts into iPSCs with only Oct4 or Klf4.

  3. extracellular vesicles tend to localize in the intestinal tract associated with epithelial cell adhesion molecule

  4. Data show that EpCAM-expressing proliferating ductal cells (PDC) could be a cellular origin of hepatocellular carcinoma (HCC), suggesting the existence of stem/progenitor-derived hepatocarcinogenesis.

  5. activation of hepatic H19RNA promoted cholestatic liver fibrosis through the ZEB1/EpCAM signaling pathway

  6. These results identify EpCAM as a substrate of matriptase and link HAI-2, matriptase, EpCAM, and claudin-7 in a functionally important pathway that causes disease when it is dysregulated.

  7. EpCAM appears to differentially regulate Langerhans cell mobility/migration in the setting of limited inflammation as compared with the intense inflammation triggered by contact sensitizers

  8. Knock-down EpCAM cell model of congenital tufting enteropathy was developed. In vivo inducible mouse model was developed resulting in mutant EpCAM protein.

  9. in addition to converting to cholangiocyte-like cells, Sox9(+)EpCAM(-) cells provide luminal space near expanded ductular structures to prevent deterioration of the injuries and potentially supply new hepatocytes to repair damaged tissues

  10. EpCAM is a highly conserved protein present in fishes, amphibians, reptiles, birds, marsupials, and placental mammals, and is subject to shedding, gamma-secretase-dependent regulated intramembrane proteolysis, and proteasome-mediated degradation.

  11. Suggest pivotal role of EpCAM in intestinal epithelial structure and integrity, with mutations resulting in congenital tufting enteropathy.

  12. mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin/beta-catenin.

  13. EpCAM contributes to formation of intestinal barrier by recruiting claudins to cell-cell junctions.

  14. These results conclusively link EpCAM expression to Langerhan cell (LC) motility/migration and LC migration to immune regulation.

  15. Results show that SSCs are the most concentrated in CD9(+)EPCAM(low/-) population and also suggest that EPCAM plays an important role in progenitor cell amplification in the mouse spermatogenic system.

  16. EpCAM could contribute substantially to the pathogenesis of lung cancer.

  17. EpCAM was required for differentiation or survival of parietal trophoblast giant cells, normal development of the placental labyrinth and establishment of a competent maternal-fetal circulation.

  18. analysis of EpCAM expression in normal, non-pathological tissues

  19. The spatiotemporal expression pattern of EpCAM changes during nephrogenesis

  20. These data suggest that EpCAM is involved in signal transduction triggering several intracellular signalling pathways using tumor cell lines in colorectal and lung cancer.

EPCAM Antigen Profile

Protein Summary

This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Gene names and symbols associated with EPCAM

  • epithelial cell adhesion molecule (EPCAM) antibody
  • epithelial cell adhesion molecule (epcam) antibody
  • epithelial cell adhesion molecule S homeolog (epcam.S) antibody
  • epithelial cell adhesion molecule (Epcam) antibody
  • CD326 antibody
  • co17-1a antibody
  • DIAR5 antibody
  • egp antibody
  • EGP-2 antibody
  • egp40 antibody
  • Egp314 antibody
  • ep-cam antibody
  • EPCAM antibody
  • EpCAM1 antibody
  • ESA antibody
  • GA733-2 antibody
  • gp40 antibody
  • hegp-2 antibody
  • HNPCC8 antibody
  • KS1/4 antibody
  • ksa antibody
  • Ly74 antibody
  • m4s1 antibody
  • MGC80540 antibody
  • mic18 antibody
  • mk-1 antibody
  • sb:cb6 antibody
  • Tacsd1 antibody
  • tacstd antibody
  • Tacstd1 antibody
  • trop1 antibody
  • wu:fj17g02 antibody
  • zgc:77119 antibody
  • zgc:110304 antibody

Protein level used designations for EPCAM

adenocarcinoma-associated antigen , cell surface glycoprotein Trop-1 , epithelial glycoprotein 314 , human epithelial glycoprotein-2 , major gastrointestinal tumor-associated protein GA733-2 , membrane component, chromosome 4, surface marker (35kD glycoprotein) , tumor-associated calcium signal transducer 1 , epithelial glycoprotein , pan-epithelial glycoprotein , tumor-associated calcium signal transducer , ep-CAM , epithelial cell adhesion molecule , Trop-1 protein , lymphocyte antigen 74 , mEGP314 , panepithelial glycoprotein 314 , protein 289A

GENE ID SPECIES
4072 Homo sapiens
403163 Sus scrofa
406454 Danio rerio
421292 Gallus gallus
446810 Xenopus laevis
459214 Pan troglodytes
481360 Canis lupus familiaris
514039 Bos taurus
677680 Macaca mulatta
100229650 Taeniopygia guttata
100302339 Ovis aries
496567 Xenopus (Silurana) tropicalis
17075 Mus musculus
171577 Rattus norvegicus
100728623 Cavia porcellus
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