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EPCAM encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins.
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Human EPCAM ELISA Kit for Sandwich ELISA - ABIN414691
Bravo, Ortega, Messina, Sanz, Fernández-Baldo, Raba: Integrated bio-affinity nano-platform into a microfluidic immunosensor based on monoclonal bispecific trifunctional antibodies for the electrochemical determination of epithelial cancer biomarker. in Clinica chimica acta; international journal of clinical chemistry 2016
Show all 2 Pubmed References
New EPCAM founder deletion causing Lynch Syndrome has been described in Polish population.
The novel and updated insights in the EpCAM field by simplifying the understanding of the biological role of this fascinating molecule, and by showing the promising therapeutic tools that have been developed by various approaches which use antibodies and vaccines for different cancer types for the clear purpose of improving patient outcome. [review]
This is the first demonstration that the low sensitivity of CellSearch(R) to detect circulating tumor cells in colorectal cancer patients is not due to the lack of EpCAM
Findings indicate that epithelial cell adhesion molecule (EpCAM) can be used as an additional distinction-marker for cystic lesions of the sellar region.
Data indicate that epithelial cell adhesion molecule (EpCAM) show high tumor distinctiveness.
After running the algorithm on two data sets [triple-negative breast cancer, (TNBC), and estrogen receptor (show ESR1 ELISA Kits)-negative breast cancer, (ERNBC)], we conclude that EpCAM and beta1 integrin are enough to accurately predict TNBC stage, being ALDH1 (show ALDH1A1 ELISA Kits), CD24 (show CD24 ELISA Kits), CD61 (show ITGB3 ELISA Kits), and CK5 (show KRT5 ELISA Kits) the necessary markers to exactly predict ERNBC stage.
Low expressions of Oct4-EpCAM in IHC and CD133 in qPCR may reveal roles in gastric cancer
EpCAM expression contributes to tumor resistance to chemotherapy in patients with ovarian cancer.
The present findings suggest that Ep-CAM expression may be associated with CRC (show CALR ELISA Kits) carcinogenesis, while the loss of Ep-CAM expression is correlated with the progression, metastasis, and poor prognosis of CRC (show CALR ELISA Kits). Ep-CAM expression may be a useful biomarker for the clinical diagnosis of CRC (show CALR ELISA Kits).
the present study identified a positive correlation between EpCAM and COX-2 (show COX2 ELISA Kits) expression in breast cancer cell lines and tissue specimens. EpCAM and COX-2 (show COX2 ELISA Kits) were associated with the prognosis of breast cancer patients.
Ep-CAM may act as a physical homophilic interaction molecule between IELs and IECs at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection [Ep-CAM]
Gene ontology analysis revealed that EpCAM controls various developmental programs, including uretric bud development, morphogenesis of branching epithelium, regulation of cell differentiation and cilium morphogenesis.
EpCAM acts as a partner of E-cadherin (show CDH1 ELISA Kits) to control adhesiveness and integrity as well as plasticity and morphogenesis within simple epithelia
identification of EpCAM in a gain-of-function screen for inducers of abnormal tissue mixing during gastrulation
Data show that EpCAM-expressing proliferating ductal cells (PDC) could be a cellular origin of hepatocellular carcinoma (HCC), suggesting the existence of stem/progenitor-derived hepatocarcinogenesis.
activation of hepatic H19RNA promoted cholestatic liver fibrosis through the ZEB1 (show ZEB1 ELISA Kits)/EpCAM signaling pathway
These results identify EpCAM as a substrate of matriptase (show ST14 ELISA Kits) and link HAI-2 (show SPINT2 ELISA Kits), matriptase (show ST14 ELISA Kits), EpCAM, and claudin-7 (show CLDN7 ELISA Kits) in a functionally important pathway that causes disease when it is dysregulated.
EpCAM appears to differentially regulate Langerhans cell mobility/migration in the setting of limited inflammation as compared with the intense inflammation triggered by contact sensitizers
Knock-down EpCAM cell model of congenital tufting enteropathy was developed. In vivo inducible mouse model was developed resulting in mutant EpCAM protein.
in addition to converting to cholangiocyte-like cells, Sox9 (show SOX9 ELISA Kits)(+)EpCAM(-) cells provide luminal space near expanded ductular structures to prevent deterioration of the injuries and potentially supply new hepatocytes to repair damaged tissues
EpCAM is a highly conserved protein present in fishes, amphibians, reptiles, birds, marsupials, and placental mammals, and is subject to shedding, gamma-secretase-dependent regulated intramembrane proteolysis, and proteasome-mediated degradation.
Suggest pivotal role of EpCAM in intestinal epithelial structure and integrity, with mutations resulting in congenital tufting enteropathy.
mTrop1/Epcam knockout mice develop congenital tufting enteropathy through dysregulation of intestinal E-cadherin (show CDH1 ELISA Kits)/beta-catenin (show CTNNB1 ELISA Kits).
EpCAM contributes to formation of intestinal barrier by recruiting claudins to cell-cell junctions.
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
, cell surface glycoprotein Trop-1
, epithelial glycoprotein 314
, human epithelial glycoprotein-2
, major gastrointestinal tumor-associated protein GA733-2
, membrane component, chromosome 4, surface marker (35kD glycoprotein)
, tumor-associated calcium signal transducer 1
, epithelial glycoprotein
, pan-epithelial glycoprotein
, tumor-associated calcium signal transducer
, epithelial cell adhesion molecule
, Trop-1 protein
, lymphocyte antigen 74
, panepithelial glycoprotein 314
, protein 289A