Epithelial Splicing Regulatory Protein 1 Proteins (ESRP1)

Xenopus laevis Epithelial Splicing Regulatory Protein 1 (ESRP1) interaction partners

1. Ptbp1 (show PTBP1 Proteins) abundance is controlled in Xenopus epidermis via alternate splicing: skipping of exon 11 is the default splicing pattern, but Esrp1 stimulates ptbp1 (show PTBP1 Proteins) expression by favoring the inclusion of exon 11 up to a level that is limited by Ptbp1 (show PTBP1 Proteins) itself.

Human Epithelial Splicing Regulatory Protein 1 (ESRP1) interaction partners

1. Results show that ESRP1 regulates CD44 (show CD44 Proteins) splice isoform switching and EMT (show ITK Proteins) in ovarian cancer cells.

2. In humans, ESRP1 is downregulated in inflamed biopsies from inflammatory bowel disease patients. ESRP1 loss is an adverse prognostic factor in colorectal cancer. Furthermore, generation of ESRP1-dependent GPR137 isoforms is altered in colorectal cancer and expression of a specific GPR137 isoform predicts colorectal cancer patient survival.

3. Our study supports the role of ESRP1 as tumor suppressor and strongly suggests that ESRPs are candidate markers for early detection, diagnosis, and prognosis of CRC (show CALR Proteins).

4. High ESRP1 expression may thus stimulate growth of cancer epithelial cells and promote colorectal cancer progression.

5. Results showed that the expression patterns of these genes were indicative of the onset of EMT (show ITK Proteins) in in-vitro models, but not in tissue samples. However, the ratio between ESRP1 or ESRP2 (show ESRP2 Proteins) and RBFOX2 (show RBM9 Proteins) significantly decreased during EMT (show ITK Proteins) and positively correlated with the EMT (show ITK Proteins)-specific phenotype in cell models. Low ESRP1/RBFOX2 (show RBM9 Proteins) ratio value was associated with a higher risk of metastasis in early breast cancer patients.

6. Downregulated ESRP1 by sirna resulted in an isoform switching from CD44v to CD44s, which modulated epithelial-mesenchymal transition.

7. ALK oncogenic activity is involved in the regulation of an epithelial mesenchymal transition phenotype in a subset of non-small cell lung carcinomas by repression of the epithelial splicing regulatory protein 1.

8. ZEB1-induced epithelial-to-mesenchymal transition and associated molecular changes in ESRP1 and CD44 (show CD44 Proteins) contribute to early pathogenesis and metastatic potential in established lung cancer

9. The molecular mechanisms by which ESRP1 and ESPR2 exert positive as well as negative effects on cancer progression have been summarized. (Review)

10. Recombinant human ESRP1-RRM3 was subjected to biomolecular NMR and its chemical shifts and structural coordinates were determined and deposited in the BioMagResBank and Protein Data Bank respectively. Its interaction with RBPMS2 (show RBPMS2 Proteins) was mapped.

Mouse (Murine) Epithelial Splicing Regulatory Protein 1 (ESRP1) interaction partners

1. Study documented the expression of Esrp1 during gonadal development and in differentiating cells of the adult gonads: in mouse fetal gonads, Esrp1 mRNA was specifically detected in germ cells of either sex and absent from somatic gonadal cells. Esrp1 mRNA was present in a gonocyte-enriched cell fraction and in all germ cells examined in postnatal testis.

2. Findings reveal that Esrp1-regulated splicing in ureteric epithelial cells plays an important role in renal development. Defects in Esrp1 KO kidneys likely reflect reduced and/or absent ureteric branching, leading to decreased nephron induction secondary to incorrect Fgfr2 (show FGFR2 Proteins) splicing and other splicing alterations

3. implicate mutations in Epithelial Splicing-Regulatory Protein 1 as a cause of SNHL and demonstrate the complex interplay between alternative splicing

4. Loss of both Esrp1 and its paralog Esrp2 (show ESRP2 Proteins) results in widespread developmental defects with broad implications to human disease.

5. The expression levels of three splicing factors, ESRP1, PTB (show PTBP1 Proteins) and SF2/ASF (show SRSF1 Proteins), are significantly altered during cardiac hypertrophy in mice.

6. ESRP1 thus acts as a physiological regulator of the finely-tuned balance between self-renewal and commitment to a restricted developmental fate.

7. Esrp1 could play an important role in the morphological changes underlying embryogenesis of the placenta and embryo.

8. Alternative splicing of CD44 (show CD44 Proteins) mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

9. Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 (show FGFR2 Proteins) splicing.