Epithelial Splicing Regulatory Protein 1 Proteins (ESRP1)

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009 [PubMed 19285943]).[supplied by OMIM, Aug 2009].. Additionally we are shipping ESRP1 Antibodies (46) and ESRP1 Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ESRP1 54845 Q6NXG1
ESRP1 207920 Q3US41
ESRP1 500409 B2RYD2
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Top ESRP1 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$338.33
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,967.33
Details

ESRP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Epithelial Splicing Regulatory Protein 1 (ESRP1) Interaction Partners

Xenopus laevis Epithelial Splicing Regulatory Protein 1 (ESRP1) interaction partners

  1. Ptbp1 (show PTBP1 Proteins) abundance is controlled in Xenopus epidermis via alternate splicing: skipping of exon 11 is the default splicing pattern, but Esrp1 stimulates ptbp1 (show PTBP1 Proteins) expression by favoring the inclusion of exon 11 up to a level that is limited by Ptbp1 (show PTBP1 Proteins) itself.

Human Epithelial Splicing Regulatory Protein 1 (ESRP1) interaction partners

  1. In humans, ESRP1 is downregulated in inflamed biopsies from inflammatory bowel disease patients. ESRP1 loss is an adverse prognostic factor in colorectal cancer. Furthermore, generation of ESRP1-dependent GPR137 isoforms is altered in colorectal cancer and expression of a specific GPR137 isoform predicts colorectal cancer patient survival.

  2. Our study supports the role of ESRP1 as tumor suppressor and strongly suggests that ESRPs are candidate markers for early detection, diagnosis, and prognosis of CRC (show CALR Proteins).

  3. High ESRP1 expression may thus stimulate growth of cancer epithelial cells and promote colorectal cancer progression.

  4. Results showed that the expression patterns of these genes were indicative of the onset of EMT (show ITK Proteins) in in-vitro models, but not in tissue samples. However, the ratio between ESRP1 or ESRP2 (show ESRP2 Proteins) and RBFOX2 (show RBM9 Proteins) significantly decreased during EMT (show ITK Proteins) and positively correlated with the EMT (show ITK Proteins)-specific phenotype in cell models. Low ESRP1/RBFOX2 (show RBM9 Proteins) ratio value was associated with a higher risk of metastasis in early breast cancer patients.

  5. Downregulated ESRP1 by sirna resulted in an isoform switching from CD44v to CD44s, which modulated epithelial-mesenchymal transition.

  6. ALK oncogenic activity is involved in the regulation of an epithelial mesenchymal transition phenotype in a subset of non-small cell lung carcinomas by repression of the epithelial splicing regulatory protein 1.

  7. ZEB1-induced epithelial-to-mesenchymal transition and associated molecular changes in ESRP1 and CD44 (show CD44 Proteins) contribute to early pathogenesis and metastatic potential in established lung cancer

  8. The molecular mechanisms by which ESRP1 and ESPR2 exert positive as well as negative effects on cancer progression have been summarized. (Review)

  9. Recombinant human ESRP1-RRM3 was subjected to biomolecular NMR and its chemical shifts and structural coordinates were determined and deposited in the BioMagResBank and Protein Data Bank respectively. Its interaction with RBPMS2 (show RBPMS2 Proteins) was mapped.

  10. Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity.

Mouse (Murine) Epithelial Splicing Regulatory Protein 1 (ESRP1) interaction partners

  1. Study documented the expression of Esrp1 during gonadal development and in differentiating cells of the adult gonads: in mouse fetal gonads, Esrp1 mRNA was specifically detected in germ cells of either sex and absent from somatic gonadal cells. Esrp1 mRNA was present in a gonocyte-enriched cell fraction and in all germ cells examined in postnatal testis.

  2. Findings reveal that Esrp1-regulated splicing in ureteric epithelial cells plays an important role in renal development. Defects in Esrp1 KO kidneys likely reflect reduced and/or absent ureteric branching, leading to decreased nephron induction secondary to incorrect Fgfr2 (show FGFR2 Proteins) splicing and other splicing alterations

  3. implicate mutations in Epithelial Splicing-Regulatory Protein 1 as a cause of SNHL and demonstrate the complex interplay between alternative splicing

  4. Loss of both Esrp1 and its paralog Esrp2 (show ESRP2 Proteins) results in widespread developmental defects with broad implications to human disease.

  5. The expression levels of three splicing factors, ESRP1, PTB (show PTBP1 Proteins) and SF2/ASF (show SRSF1 Proteins), are significantly altered during cardiac hypertrophy in mice.

  6. ESRP1 thus acts as a physiological regulator of the finely-tuned balance between self-renewal and commitment to a restricted developmental fate.

  7. Esrp1 could play an important role in the morphological changes underlying embryogenesis of the placenta and embryo.

  8. Alternative splicing of CD44 (show CD44 Proteins) mRNA by ESRP1 enhances lung colonization of metastatic cancer cell.

  9. Epithelial splicing regulatory proteins 1/2 (ESRP1/2) are epithelial cell-type-specific regulators of FGFR2 (show FGFR2 Proteins) splicing.

ESRP1 Protein Profile

Protein Summary

ESPR1 is an epithelial cell-type-specific splicing regulator (Warzecha et al., 2009

Gene names and symbols associated with ESRP1

  • epithelial splicing regulatory protein 1 (ESRP1)
  • epithelial splicing regulatory protein 1 L homeolog (esrp1.L)
  • epithelial splicing regulatory protein 1 (Esrp1)
  • epithelial splicing regulatory protein 1 (esrp1)
  • 2210008M09Rik protein
  • A630065D16 protein
  • BC031468 protein
  • Rbm35a protein
  • RGD1560481 protein
  • RMB35A protein
  • wu:fi28a07 protein
  • zgc:154050 protein

Protein level used designations for ESRP1

epithelial splicing regulatory protein 1 , RNA-binding motif protein 35A , RNA-binding protein 35A , RNA binding motif protein 35A

GENE ID SPECIES
100029848 Monodelphis domestica
100075586 Ornithorhynchus anatinus
100432775 Pongo abelii
100483880 Ailuropoda melanoleuca
100545364 Meleagris gallopavo
379211 Xenopus laevis
54845 Homo sapiens
207920 Mus musculus
500409 Rattus norvegicus
560190 Danio rerio
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