Epoxide Hydrolase 2, Cytoplasmic Proteins (EPHX2)

EPHX2 encodes a member of the epoxide hydrolase family. Additionally we are shipping Epoxide Hydrolase 2, Cytoplasmic Antibodies (90) and Epoxide Hydrolase 2, Cytoplasmic Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
EPHX2 2053 P34913
EPHX2 13850 P34914
EPHX2 65030 P80299
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Top Epoxide Hydrolase 2, Cytoplasmic Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Baculovirus infected Insect Cells Human His tag 100 μg 14 to 16 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Yeast Rat His tag   1 mg 60 to 71 Days

EPHX2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Interaction Partners

Human Epoxide Hydrolase 2, Cytoplasmic (EPHX2) interaction partners

  1. Results indicate that soluble epoxide hydrolase (sEH, EPHX2) p.Lys55Arg and p.Arg287Gln polymorphisms do not significantly modify survival after an acute coronary syndrome (ACS) event.

  2. Daunorubicin induces cardiotoxicity through a sEH-mediated epoxyeicosatrienoic acids degradation-dependent mechanism.

  3. Increased epoxyeicosatrienoic acids may be part of a protective mechanism in human ulcerative colitis, with increased CYP2J2 and reduced soluble epoxide hydrolase expression

  4. the A allele of exonic polymorphism in EPHX2 rs751141 is negatively associated with the incidence of diabetic nephropathy in the Chinese type 2 diabetes population, which could be modulated by homocysteine level status.

  5. Single nucleotide polymorphism of EPHX2 rs751141 is associated with Early Neurological Deterioration.

  6. The activity of Ephx2 promoter-coding luciferase was significantly attenuated in HEK293T cells treated with 17beta-E2.

  7. hypomethylation of the promoter region of EPHX2 and K55R polymorphism were associated with significant increased risk of pre-eclampsia.

  8. Study demonstrated an isolated gene change, sEH R287Q, in a core family of familial hypercholesterolemia (FH). The results showed that sEH R287Q decreased the expression level and hydrolase activity of sEH, decreased the binding of LDL to LDLR and LDL internalization in cultured hepatocyte cell line BEL-7402.

  9. Soluble epoxide hydrolase plays role in the choroidal neovascularization

  10. Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors.

  11. Results showed that among type 2 diabetic patients, the combined effect of MTHFR TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group.

  12. we describe the bacterial expression of the recombinant N-terminal domain of sEH-P and the development of a high-throughput screening protocol using a sensitive and commercially available substrate fluorescein diphosphate. The usability of the assay system was demonstrated and novel inhibitors of sEH-P were identified.

  13. The WT sEH formed a very tight dimer, with a KD/M in the low picomolar range. Only R287Q resulted in a large change of the KD/M However, human tissue concentrations of sEH suggest that it is always in its dimer form independently of the SNP.

  14. The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD

  15. EPHX2 polymorphism , might be important determinant of hydrochlorothiazide treatment in patients with hypertension.

  16. This study meta-analysis results did not show significant associations between the polymorphisms of EPHX2.

  17. EPHX2 Variants are associated with Ischemic Stroke.

  18. Because Epoxide Hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.

  19. Increased levels of soluble epoxide hydrolase in the brain of depressed patients

  20. Interaction among CYP2C8, EPHX2, and CYP4A11 Gene Variants Significantly Increases the Risk for Ischemic Stroke.

Mouse (Murine) Epoxide Hydrolase 2, Cytoplasmic (EPHX2) interaction partners

  1. sEH is a key player in neurite outgrowth of neurons, olfactory bulb development in the brain, and the development of anxiety-like behavior, by regulating the CaMKII-GSK3alpha/beta signaling pathway.

  2. These findings suggest that increased activity of sEH in the PFC plays a key role in the etiology of neurodevelopmental disorders in offspring after MIA. Therefore, sEH represents a promising prophylactic or therapeutic target for neurodevelopmental disorders in offspring after MIA.

  3. High fat diet-caused renal injury involved the inactivation of Pax2 and Ampk, and the activation of soluble epoxide hydrolase (sEH), in a murine model.

  4. Data show that soluble epoxide hydrolase (sEH) deletion was associated with a significant increase in adiponectin and heme-oxygenase 1 (HO-1) mRNA expression.

  5. Gene analysis indicated that soluble epoxide hydrolase 2 (sEH) was significantly upregulated in Nox4DN endothelial cells (EC). Inhibition of sEH activity in Nox4DN EC suppressed inflammation and macrophage adhesion to EC.

  6. Estrogen/estrogen receptor-dependent methylation of the promoter region silences Ephx2 expression.

  7. Data (including data from studies in knockout mice) suggest that expression of Ephx2 measured as mRNA, protein, and enzymatic activity is markedly up-regulated in corneal epithelium and retina in type 1 and type 2 diabetes; induction of Ephx2 may play roles in diabetic cataracts, diabetic retinopathy, and delayed wound healing.

  8. These findings establish sEH in podocytes as a significant contributor to renal function under hyperglycemia. These data suggest that sEH is a potential therapeutic target for podocytopathies

  9. Findings identify soluble epoxide hydrolase (sEH) in podocytes as a contributor to signaling events in acute renal injury and suggest that sEH inhibition may be of therapeutic value in proteinuria.

  10. These data demonstrate that genetic deletion of sEH resulted in an altered oxylipin profile, which may have led to an enhanced CRH response.

  11. Deficiency or pharmacological inhibition of sEH protected mice from the lipopolysaccharide-induced decrease in systemic arterial oxygen concentration.

  12. Lungs of Ephx2(-/-) mice had a less pronounced inflammatory response and less autophagy with mild distal airspace enlargement accompanied by restored lung function and steady weight gain

  13. over-expression of sEH enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs. These results suggest a possible interaction between sEH, A1AR, and KATP channels in regulating vascular tone.

  14. we identified 31 significantly expressed proteins in mouse hippocampus using proteomics analysis and constructed a protein-protein interaction network associated with EPHX2 gene knockout

  15. The role of soluble epoxide hydrolase in the pathophysiology of depression and resilience to repeated social defeat stress

  16. CYP-eicosanoid profiling also revealed that renal, but not plasma and hepatic, 20-HETE levels were significantly increased in sEH-KO compared to WT mice

  17. Dual inhibition of c-Raf and soluble epoxide hydrolase by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.

  18. sEH deficiency attenuated tyrosine hydroxylase-positive cell loss in a paraquat-induced mouse model of Parkinson's.

  19. Simultaneous inhibition of sEH and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1-Cre mice.

  20. Suggest role for Ephx2 in vascular smooth muscle phenotypic modulation and migration in the development of atherosclerosis.

Cow (Bovine) Epoxide Hydrolase 2, Cytoplasmic (EPHX2) interaction partners

  1. AP-1 activation is involved in the transcriptional up-regulation of sEH by angiotensin II (Ang II) in endothelial cells, which may contribute to Ang II-induced hypertension[soluble epoxide hydrolase ]

Epoxide Hydrolase 2, Cytoplasmic (EPHX2) Protein Profile

Protein Summary

This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described.

Gene names and symbols associated with EPHX2

  • epoxide hydrolase 2 (EPHX2)
  • soluble epoxide hydrolase (SEH2)
  • soluble epoxide hydrolase (PTRG_01276)
  • Soluble epoxide hydrolase (Deima_0402)
  • Soluble epoxide hydrolase (Deipr_0144)
  • Soluble epoxide hydrolase (Psed_0418)
  • Soluble epoxide hydrolase (Fluta_3767)
  • alpha/beta hydrolase (HALXA_RS12710)
  • epoxide hydrolase 2, cytoplasmic (Ephx2)
  • epoxide hydrolase 2 (Ephx2)
  • CEH protein
  • Eph2 protein
  • SEH protein
  • sEP protein

Protein level used designations for EPHX2

epoxide hydrolase 2 , soluble epoxide hydrolase , Soluble epoxide hydrolase , bifunctional epoxide hydrolase 2 , epoxide hydratase , epoxide hydrolase 2, cytosolic , epoxide hydrolase, soluble , cytosolic epoxide hydrolase , epoxide hydrolase 2C , CEH , SEH

421999 Gallus gallus
4836743 Scheffersomyces stipitis CBS 6054
6339307 Pyrenophora tritici-repentis Pt-1C-BFP
10149715 Deinococcus maricopensis DSM 21211
10255604 Deinococcus proteolyticus MRP
10362229 Pseudonocardia dioxanivorans CB1190
10399141 Fluviicola taffensis DSM 16823
10798230 Halopiger xanaduensis SH-6
2053 Homo sapiens
13850 Mus musculus
65030 Rattus norvegicus
477373 Canis lupus familiaris
414425 Sus scrofa
511716 Bos taurus
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