Epoxide Hydrolase 2, Cytoplasmic Proteins (EPHX2)

Human Epoxide Hydrolase 2, Cytoplasmic (EPHX2) interaction partners

1. Interestingly, rs2279590 locus has a widespread enhancer effect on two nearby genes, protein tyrosine kinase 2 beta (PTK2B (show PTK2B Proteins)) and epoxide hydrolase-2 (EPHX2); both of which have been previously associated with AD as risk factors.

2. Results showed that among type 2 diabetic patients, the combined effect of MTHFR (show MTHFR Proteins) TT and EPHX2 GG or GA + AA genotype has a higher risk of ischemic stroke compared with the control group.

3. we describe the bacterial expression of the recombinant N-terminal domain of sEH-P and the development of a high-throughput screening protocol using a sensitive and commercially available substrate fluorescein diphosphate. The usability of the assay system was demonstrated and novel inhibitors of sEH-P were identified.

4. The WT sEH formed a very tight dimer, with a KD/M in the low picomolar range. Only R287Q resulted in a large change of the KD/M However, human tissue concentrations of sEH suggest that it is always in its dimer form independently of the SNP.

5. The EPHX2 Lys55Arg polymorphism is associated with AKI following cardiac surgery in patients without preexisting CKD

6. EPHX2 polymorphism , might be important determinant of hydrochlorothiazide treatment in patients with hypertension.

7. This study meta-analysis results did not show significant associations between the polymorphisms of EPHX2.

8. EPHX2 Variants are associated with Ischemic Stroke.

9. Because Epoxide Hydrolase 2 (EPHX2) was identified as a novel AN susceptibility gene, and because its protein product, soluble epoxide hydrolase (sEH), converts bioactive epoxides of polyunsaturated fatty acid (PUFA) to the corresponding diols, lipidomic and metabolomic targets of EPHX2 were assessed to evaluate the biological functions of EPHX2 and their role in AN.

10. Increased levels of soluble epoxide hydrolase in the brain of depressed patients

Mouse (Murine) Epoxide Hydrolase 2, Cytoplasmic (EPHX2) interaction partners

1. These findings establish sEH in podocytes as a significant contributor to renal function under hyperglycemia. These data suggest that sEH is a potential therapeutic target for podocytopathies

2. Findings identify soluble epoxide hydrolase (sEH) in podocytes as a contributor to signaling events in acute renal injury and suggest that sEH inhibition may be of therapeutic value in proteinuria.

3. These data demonstrate that genetic deletion of sEH resulted in an altered oxylipin profile, which may have led to an enhanced CRH (show CRH Proteins) response.

4. Deficiency or pharmacological inhibition of sEH protected mice from the lipopolysaccharide-induced decrease in systemic arterial oxygen concentration.

5. Lungs of Ephx2(-/-) mice had a less pronounced inflammatory response and less autophagy with mild distal airspace enlargement accompanied by restored lung function and steady weight gain

6. over-expression of sEH enhances A1AR-dependent contraction and reduces KATP channel-dependent relaxation in MAs. These results suggest a possible interaction between sEH, A1AR, and KATP channels in regulating vascular tone.

7. we identified 31 significantly expressed proteins in mouse hippocampus using proteomics analysis and constructed a protein-protein interaction network associated with EPHX2 gene knockout

8. The role of soluble epoxide hydrolase in the pathophysiology of depression and resilience to repeated social defeat stress

9. CYP-eicosanoid profiling also revealed that renal, but not plasma and hepatic, 20-HETE levels were significantly increased in sEH-KO compared to WT mice

10. Dual inhibition of c-Raf (show RAF1 Proteins) and soluble epoxide hydrolase by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.

Cow (Bovine) Epoxide Hydrolase 2, Cytoplasmic (EPHX2) interaction partners

1. AP-1 (show JUN Proteins) activation is involved in the transcriptional up-regulation of sEH by angiotensin II (Ang II) in endothelial cells, which may contribute to Ang II (show AGT Proteins)-induced hypertension[soluble epoxide hydrolase ]