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EHF encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs).
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Cow (Bovine) Polyclonal EHF Primary Antibody for IHC, WB - ABIN2778625
Ko, Kitchen, Wang, Threat, Wang, Hasegawa, Sun, Grahovac, Kargul, Lim, Cui, Sano, Tanaka, Liang, Mason, Paonessa, Sauls, DePalma, Sharara, Rowe, Eppig, Morrell, Doi: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. in Development (Cambridge, England) 2000
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A negative correlation between EHF protein and miR206 expression.
Human prostate tumors with IL-6 (show IL6 Antibodies) elevation and loss of ESE3/EHF were associated with STAT3 (show STAT3 Antibodies) activation and displayed upregulation of genes related to cell adhesion, cancer stem-like and metastatic spread.
EHF is a novel functional oncogene (show RAB1A Antibodies) in thyroid cancer by transcriptionally regulating HER2 (show ERBB2 Antibodies) and HER3 (show ERBB3 Antibodies), and may represent a potential therapeutic target for this cancer
The role of EHF in modifying Cystic Fibrosis (show S100A8 Antibodies) lung disease severity.
is a novel functional oncogene (show RAB1A Antibodies) in gastric cancer by regulating the human epidermal growth factor receptor (show EGFR Antibodies) (HER) family of receptor tyrosine kinases.
tight control by ESE3/EHF over the Lin28 (show LIN28A Antibodies)/let-7 axis is a critical barrier to malignant transformation.
ESE3 as a negative regulator of pancreatic ductal adenocarcinomas (PDAC) progression and metastasis by enforcing E-cadherin (show CDH1 Antibodies) upregulation.
EHF activates expression of the SAM pointed domain-containing ETS transcription factor, which contributes to goblet cell hyperplasia.
Results found that EHF was elevated in ovarian cancer tissues and correlated with short survival. Its overexpression in ovarian cancer cells promoted cell growth and metastasis, and inhibited cell apoptosis.
This study suggests that ESE3 plays an important role in the carcinogenesis of Esophageal Squamous Cell Carcinoma through changes in subcellular localization and may act as a tumor suppressor gene in Esophageal Squamous Cell Carcinoma.
These data provide insights into the mechanisms underlying epithelial development and aging, identifying EHF as a regulator of cornea epithelial identity
This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene.
ETS homologous factor
, ESE3 transcription factor
, ETS domain-containing transcription factor
, epithelium-specific Ets transcription factor 3
, ets homologous factor