Ets Variant 1 Proteins (ETV1)

ETV1 encodes a member of the ETS (E twenty-six) family of transcription factors. Additionally we are shipping ETV1 Antibodies (89) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ETV1 2115 P50549
Rat ETV1 ETV1 362733  
ETV1 14009 P41164
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Top ETV1 Proteins at

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Wheat germ Human GST tag 10 μg 11 to 12 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
Yeast Cow His tag   1 mg 60 to 71 Days

ETV1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Ets Variant 1 (ETV1) Interaction Partners

Human Ets Variant 1 (ETV1) interaction partners

  1. Our data indicate that miR-17-5p acts as a tumour suppressor in Triple-negative breast cancer (TNBC)by targeting ETV1, and a low-abundance of miR-17-5p may be involved in the pathogenesis of TNBC. These findings indicate that miR-17-5p may be a therapeutic target for TNBC

  2. four oncogenic ETS (ERG, ETV1, ETV4, and ETV5), and no other ETS, interact with the Ewing's sarcoma breakpoint protein, EWS.

  3. Our results indicate that assessing AP1 and PEA3 transcription factor status might be a good indicator of OAC status. However, we could not detect any associations with disease stage or patient treatment regime. This suggests that the PEA3-AP1 regulatory module more likely contributes more generally to the cancer phenotype. In keeping with this observation, depletion of ETV1 and/or ETV4 causes an OAC cell growth defect

  4. Structured and disordered regions cooperatively mediate DNA-binding autoinhibition of ETV1, ETV4 and ETV5.

  5. the prostate cancer-related oncogenic E26 transformation-specific (ETS) transcription factors, ETV1, ETV4, and ETV5, were required for TAZ gene transcription in PC3 prostate cancer cells

  6. C646 treatment attenuated ETV1 protein expression and inactivated KIT-dependent pathways. Taken together, the present study suggests that CBP/p300 may serve as novel antineoplastic targets and that use of the selective HAT inhibitor C646 is a promising antitumor strategy for Gastrointestinal stromal tumors.

  7. these data reveal a JMJD2A/ETV1/YAP1 axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.

  8. conclude that ETV1 is specifically expressed in the majority of gastrointestinal stromal tumors, even in some KIT-negative cases

  9. ETV1 and COP1 are a pair of independent predictors of prognosis for triple-negative breast cancer.

  10. ETV1 overexpression is associated with prostate cancer aggressiveness.

  11. Results show that ETV1 was upregulated at a higher rate in Gastrointestinal stromal tumor and was correlated with KIT expression.

  12. These results illuminate the complex interplay of AR, ETV1, and PTEN pathways in pre-cancerous neoplasia and early tumorigenesis

  13. YK-4-279 is a potent inhibitor of ETV1 and inhibits both the primary tumor growth and metastasis of fusion positive prostate cancer xenografts.

  14. mutation of the KIT protein that stabilizes ETV1 is likely to be a key step by which an endogenous brain-cell progenitor may form a germinoma.

  15. ETV1 expression is a rare event in human melanoma and seems to be rather based on hyperactivation of MAPK signals, by BRAF (V600E) mutation, than on ETV1 gene amplification.

  16. developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes

  17. Elevated levels of either wild-type ETV1 or its truncated derivative, dETV1, which mimics the product of an oncogenic rearrangement in certain tumors, results in increased expression of mRNA for p14ARF, a known activator of p53.

  18. These results point to a new avenue for pharmacologic ETV1 inhibition and may inform a general means to discover small molecule perturbagens of transcription factor oncoproteins.

  19. The gastrointestinal stromal tumor-specific transcription factor ETV1 may have no prognostic potential, whereas its downstream gene KCTD10 is associated with a favorable prognosis.

  20. ETV1 expression is significantly correlated with Snail expression in human gastric tumor samples. In summary, we present data that ETV1 promotes Snail expression to induce EMT-like metastatic progression in gastric cancer.

Xenopus laevis Ets Variant 1 (ETV1) interaction partners

  1. we conclude that Etv1 acts downstream of FGF signaling to regulate the initiation of neurogenesis in the Xenopus retina.

Mouse (Murine) Ets Variant 1 (ETV1) interaction partners

  1. Here, we present a model in which the ETV1 promoter is used to specifically and inducibly drive Cre recombinase in ICC as a strategy to study GIST pathogenesis.

  2. Loss of Etv1 resulted in a complete disruption of the normal sodium current heterogeneity that exists between atrial, VCS, and ventricular myocytes.

  3. we described a RET-ER81-Neuregulin1 signaling pathway in neurons innervating Pacinian corpuscle somatosensory end organs, which is essential for communication between the innervating axon and the end organ

  4. Thus, taken into consideration the mechanism that controls the upregulation of maturation genes involved in synaptic formation, these results indicate that Etv1 orchestrates the activity-dependent regulation of both maturation and immaturation genes in developing granule cells and plays a key role in specifying the identity of mature granule cells in the cerebellum.

  5. downstream ETV1/4/5 transcriptional up-regulation appears highly sensitive and specific and can be used as a reliable molecular signature and diagnostic method for CIC fusion positive SBRCTs

  6. these data reveal a JMJD2A/ETV1/YAP1 axis that promotes prostate cancer initiation and that may be a suitable target for therapeutic inhibition.

  7. this study shows that network activity dynamically modulates the properties of fast-spiking (FS) interneurons through the postmitotic expression of the transcriptional regulator Er81.

  8. Data showed that ETV1 knockdown reduced KIT expression and GIST proliferation.

  9. both Etv1 and Ewsr1 were necessary for Fgf10 expression and elongation of the limb bud.

  10. ETV1 appeared to support development of invasive adenocarcinoma under the background of full Pten loss

  11. Study shows that the NR2C and Tiam1 maturation genes are synergistically controlled by the activity-dependent induction of Etv1.

  12. The coordinate expression of Etv1 with POMC cell differentiation and its interaction with the highly cell-restricted Tpit factor indicate that Etv1 participates in a combinatorial code for pituitary cell-specific gene expression.

  13. Etv1 orchestrates the activity-dependent gene regulation in the terminal maturation program and specifies the identity of cerebellar granule cells.

  14. ER81 is not necessary for expression of the OB dopaminergic gene cassette and that the DA-motif is not involved in differentiation of the mammalian OB dopaminergic phenotype.

  15. Studies indicate that Etv1 not only mediates specification of dopaminergic identity, but is also required for the proliferation and maintenance of bulbar dopaminergic neurons.

  16. Formation of supernumerary muscle spindles at the expense of Golgi tendon organs in ER81-deficient mice

  17. Few if any DRG neurons from Bax(-/-)/NT3(-/-) mice expressed ER81 protein. Expression of a NT3 transgene in muscle restored DRG ER81 expression.

  18. ER81 is a transcription factor in the ets family, within which it forms the PEA3 group.

  19. A neuron class defined by a molecular criterion doesn't segregate with that defined by an anatomical criterion; ER81 is involved in cell differentiation of a subset of layer 5 projection neurons, and this mechanism is conserved among rodents and primates.

  20. Etv1 is required for Pacinian corpuscle development.

Zebrafish Ets Variant 1 (ETV1) interaction partners

  1. er81 embryonic expression regulation does not require FGF signalling.

ETV1 Protein Profile

Protein Summary

This gene encodes a member of the ETS (E twenty-six) family of transcription factors. The ETS proteins regulate many target genes that modulate biological processes like cell growth, angiogenesis, migration, proliferation and differentiation. All ETS proteins contain an ETS DNA-binding domain that binds to DNA sequences containing the consensus 5'-CGGA

Gene names and symbols associated with Ets Variant 1 Proteins (ETV1)

  • ETS variant 1 (etv1)
  • ETS variant 1 (ETV1)
  • ets variant 1 (Etv1)
  • ETS variant 1 S homeolog (etv1.S)
  • ets variant 1 (etv1)
  • ER81 protein
  • Etsrp81 protein
  • MGC75591 protein
  • XER81 protein

Protein level used designations for Ets Variant 1 Proteins (ETV1)

ets variant 1 , ets domain protein , ets variant gene 1 , ETS translocation variant 1 , ets-related protein 81 , ets-related transcription factor XER81 , ets related protein 81 , ETS transcription factor Er81 , er81

394827 Xenopus (Silurana) tropicalis
463270 Pan troglodytes
100173436 Pongo abelii
100555473 Anolis carolinensis
100594736 Nomascus leucogenys
2115 Homo sapiens
475246 Canis lupus familiaris
362733 Rattus norvegicus
398358 Xenopus laevis
395748 Gallus gallus
540846 Bos taurus
14009 Mus musculus
563876 Danio rerio
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