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The protein encoded by XPO6 is a member of the importin-beta family. Additionally we are shipping Exportin 6 Antibodies (16) and and many more products for this protein.
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These results shed light on the crucial role of LN1 in quiescence and differentiation and how defects in the LN1/PI3K/XPO6/N-actin axis explain the loss of tissue homeostasis and growth control that contributes to malignant progression.
Data suggest actin accumulation in senescent cells is due to the failure of RanGTP restoration with ATP deficiency and NTF2 (show NUTF2 Proteins) accumulation, resulting in decreased actin export via Exp6 inactivation.
identify exportin 6 (Exp6) as a novel family member from higher eukaryotes and show that it mediates nuclear export of profilin.actin complexes
Measurements of nuclear export rates and depletion studies clarified that nuclear export of actin is mediated by exportin 6.
The protein encoded by this gene is a member of the importin-beta family. Members of this family are regulated by the GTPase Ran to mediate transport of cargo across the nuclear envelope. This protein has been shown to mediate nuclear export of profilin-actin complexes. A pseudogene of this gene is located on the long arm of chromosome 14. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
, exportin 6
, ran-binding protein 20
, RAN binding protein 20