anti-F-Box Protein 4 (FBXO4) Antibodies

FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping F-Box Protein 4 Kits (12) and F-Box Protein 4 Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FBXO4 26272 Q9UKT5
FBXO4 106052 Q8CHQ0
FBXO4 310363  
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Top anti-F-Box Protein 4 Antibodies at antibodies-online.com

Showing 10 out of 92 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:312500 Positive Control: 293T cell lysate 100 μL 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: OVCAR-3 cell lysate FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 WB Suggested Anti-FBXO4 Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:1562500 Positive Control: OVCAR-3 cell lysate FBXO4 is supported by BioGPS gene expression data to be expressed in OVCAR3 100 μL 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, IHC   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated WB Whole cell extracts prepared from U2OS cells, or insect Sf9 cells expressing Flag-FBX4, were resolved by SDS-PAGE and transferred to nitrocellulose. FBX4 was detected using ’s anti-FBX4 at a 1:500 dilution, in TBS buffer containing 0.1% Tween-20, followed by peroxidase conjugated anti-rabbit IgG. Personal Communication. A, Diehl, Univ. of Pennsylvania, Philadelphia, PA. 100 μL 5 to 7 Days
$598.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg 6 to 7 Days
$429.84
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FBXO4 Antibody (Center) in Y79 cell line lysates (35ug/lane). FBXO4 (arrow) was detected using the purified Pab. 0.4 mL 6 to 8 Days
$484.00
Details
Human Goat Un-conjugated ELISA, IHC, IHC (p) Anti-FBXO4 antibody IHC staining of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody ABIN962656 concentration 41396 ug/ml. Anti-FBXO4 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Bat Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Cow Rabbit Un-conjugated WB 100 μL 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of FBXO4 Antibody in Y79 cell line lysates (35ug/lane) 400 μL 2 to 3 Days
$515.63
Details

Top referenced anti-F-Box Protein 4 Antibodies

  1. Human Polyclonal FBXO4 Primary Antibody for WB - ABIN233769 : Pontano, Aggarwal, Barbash, Brown, Bassing, Diehl: Genotoxic stress-induced cyclin D1 phosphorylation and proteolysis are required for genomic stability. in Molecular and cellular biology 2008 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal FBXO4 Primary Antibody for IF, WB - ABIN538338 : den Engelsman, Keijsers, de Jong, Boelens: The small heat-shock protein alpha B-crystallin promotes FBX4-dependent ubiquitination. in The Journal of biological chemistry 2003 (PubMed)
    Show all 3 Pubmed References

  3. Cow (Bovine) Polyclonal FBXO4 Primary Antibody for WB - ABIN2774698 : Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007 (PubMed)

  4. Human Polyclonal FBXO4 Primary Antibody for EIA, WB - ABIN952288 : Zeng, Wang, Yang, Chen, Yang, Diehl, Liu, Lei: Structural basis of selective ubiquitination of TRF1 by SCFFbx4. in Developmental cell 2010 (PubMed)
    Show all 3 Pubmed References

  5. Cow (Bovine) Polyclonal FBXO4 Primary Antibody for ELISA - ABIN4271628 : Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer. in Cancer cell 2008 (PubMed)

More Antibodies against F-Box Protein 4 Interaction Partners

Human F-Box Protein 4 (FBXO4) interaction partners

  1. in head and neck squamous cell carcinoma, fragile X mental retardation syndrome related protein 1 (Fxr1) overexpression correlates with reduced F-box protein 4 (Fbxo4) levels.

  2. FBXO4 is the E3 ubiquitin ligase to interact with and promote Mcl-1 ubiquitination and degradation.

  3. results define the impact of alternative splicing on Fbx4 function, and suggest that the attenuated cyclin D1 degradation by these novel Fbx4 isoforms provides a new insight for aberrant cyclin D1 expression in human cancers.

  4. The FBXO4 I377M mutant exhibits impaired cyclin D1 recruitment and ubiquitylation.

  5. 14-3-3varepsilon binds to Ser12-phosphorylated Fbx4 to mediate dimerization and function.

  6. Biochemical studies indicate that both the N-terminal domain and a loop connecting the linker and C-terminal domain of Fbx4 are critical for the dimerization and activation of the protein.

  7. results reveal an atypical small GTPase domain within Fbx4 as a substrate-binding motif for SCF(Fbx4) and uncover a mechanism for selective ubiquitination and degradation of TRF1 in telomere homeostasis control

  8. Fbx4 is a central regulator of Pin2/TRF1 protein abundance and alterations in the stability of Pin2/TRF1 can have a dramatic impact on telomere length

  9. SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1.

  10. Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer.

Mouse (Murine) F-Box Protein 4 (FBXO4) interaction partners

  1. Collectively, our data support a role for FBXO4 as a suppressor of esophageal tumorigenesis

  2. This study demonstrates that Fbxo4 deficiency induces Braf-driven melanoma and that this phenotype depends on cyclin D1 accumulation in mice, underscoring the importance of this ubiquitin ligase in tumor suppression.

  3. Fbx4 expression is essential for cell homeostasis in somatic cells. Fbx4 ablation predisposes mice to multiple tumor phenotypes, with concomitant cyclin D1 deregulation and nuclear accumulation

  4. SCF(FBX4-alphaB crystallin) is an E3 ubiquitin ligase that promotes ubiquitin-dependent degradation of Thr286-phosphorylated cyclin D1.

  5. Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase.

F-Box Protein 4 (FBXO4) Antigen Profile

Protein Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.

Gene names and symbols associated with anti-F-Box Protein 4 (FBXO4) Antibodies

  • F-box protein 4 (FBXO4) antibody
  • F-box protein 4 (Fbxo4) antibody
  • F-box protein 4 (fbxo4) antibody
  • F-box protein 4 L homeolog (fbxo4.L) antibody
  • 1700096C12Rik antibody
  • AI851261 antibody
  • AW494535 antibody
  • fbx4 antibody
  • FBXO4 antibody
  • si:dkey-46a10.2 antibody

Protein level used designations for anti-F-Box Protein 4 (FBXO4) Antibodies

F-box only protein 4 , F-box protein Fbx4 , F-box protein 4 , F-box only protein 4-like

GENE ID SPECIES
26272 Homo sapiens
106052 Mus musculus
310363 Rattus norvegicus
431586 Gallus gallus
489220 Canis lupus familiaris
534852 Bos taurus
548694 Xenopus (Silurana) tropicalis
697007 Macaca mulatta
737372 Pan troglodytes
100158284 Xenopus laevis
100406305 Callithrix jacchus
100600195 Nomascus leucogenys
100194812 Salmo salar
101116349 Ovis aries
100735926 Cavia porcellus
100319387 Danio rerio
100522958 Sus scrofa
100856557 Canis lupus familiaris
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