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FBXW5 encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXW5 Kits (13) and FBXW5 Proteins (4) and many more products for this protein.
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Human Polyclonal FBXW5 Primary Antibody for WB - ABIN1881341
Minoda, Sakurai, Kobayashi, Yoshimura, Takaesu: An F-box protein, FBXW5, negatively regulates TAK1 MAP3K in the IL-1beta signaling pathway. in Biochemical and biophysical research communications 2009
Show all 5 Pubmed References
oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2
DLC1 was ubiquitinated and degraded by cullin 4A-RING ubiquitin ligase (CRL4A) complex interaction with DDB1 and the FBXW5 substrate receptor.
Identify Fbxw5-driven fluctuation of Eps8 levels as an important mechanism that contributes to cell-shape changes during entry into-and exit from-mitosis.
Fbxw5 enhances sumoylation of nuclear c-Myb
FBXW5 levels are controlled by the anaphase-promoting (APC/C) complex, which targets FBXW5 for degradation during mitosis and G1, thereby helping to reset the centrosome duplication machinery.
Results indicate that FBW5-DDB1-CUL4-ROC1 is an E3 ubiquitin ligase regulating TSC2 protein stability and TSC complex turnover.
These results suggest that FBXW5 negatively regulates TAK1 in the IL-1beta signaling pathway.
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated mRNA decay (NMD) candidates, hence not represented.
F-box and WD-40 domain protein 5
, F-box/WD repeat-containing protein 5
, F-box and WD-40 domain-containing protein 5
, WD repeat-containing F-box protein FBW5
, F-box protein Fbw5