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Functions in an early step of clathrin-mediated endocytosis. Additionally we are shipping FCH Domain Only 1 Kits (4) and and many more products for this protein.
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Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement.
The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2.
show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub
study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation
Involved in clathrin-coated vesicle formation.
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors (By similarity).
FCH domain only 1
, FCH domain only protein 1-like
, FCH domain only protein 1