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Functions in an early step of clathrin-mediated endocytosis. Additionally we are shipping FCHO2 Kits (4) and and many more products for this protein.
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Human Polyclonal FCHO2 Primary Antibody for IHC, IHC (p) - ABIN4311214
Sochacki, Dickey, Strub, Taraska: Endocytic proteins are partitioned at the edge of the clathrin lattice in mammalian cells. in Nature cell biology 2017
Fcho1/2Eps15/RAP-2 ternary complexes to facilitate conformational activation of AP-2 by the Fcho1/2 interdomain linker to promote AP-2 cargo engagement.
The central linker of FCHO proteins acts as an allosteric regulator of the prime endocytic adaptor, AP-2.
FCHO2 regulates the size of clathrin structures, and its interaction with Dab2 is needed for LDLR endocytosis under conditions of low AP2.
show that the mu-homology domain of FCHO1/2 represents an endocytic interaction hub
This structure shows a distant relationship to curvature-sensing BAR modules, and suggests how similar coiled-coil architectures in the BAR superfamily have evolved to expand the repertoire of membrane-sculpting possibilities
FCHO2 regulates clathrin-mediated endocytosis through its interactions with membranes and Eps15.
study reports FCHo1/2 were required for plasma membrane clathrin-coated vesicle (CCV) budding & marked sites of CCV formation
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP- 2-dependent endocytosis of the transferin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor.
FCH domain only 2
, FCH domain only protein 2