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FIP1L1 encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors.
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Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1-PDGFRA (show PDGFRA Proteins) gene fusion.
FIP1L1/ PDGFRA (show PDGFRA Proteins) associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.
F604S exchange in FIP1L1-PDGFRA (show PDGFRA Proteins) enhances FIP1L1-PDGFRA (show PDGFRA Proteins) protein stability via SHP-2 (show PTPN11 Proteins) and SRC (show SRC Proteins) and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.
FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.
FP fusion gene favors secondary KIT mutations in MCs (show SMCP Proteins) via growth and proliferation signals or that a yet unknown mechanism causes genomic instability with independent evolution of FP and KIT D816V
Oncostatin M (show OSM Proteins) is a FIP1L1/PDGFRA (show PDGFRA Proteins)-dependent mediator of cytokine production in chronic eosinophilic leukemia.
description of polycythemia vera (show IGF2BP3 Proteins) concurrent with FIP1L1-PDGFRA (show PDGFRA Proteins)-positive myeloproliferative neoplasm with eosinophilia [case report]
Data show that the cyclin-dependent kinase 7/9 inhibitor (CDK7/9 inhibitor) potently inhibits FIP1L1-PDGFRalpha-positive Bcr-Abl-positive chronic myeloid leukemia (CML) cells.
results strongly suggest that JAK2 (show JAK2 Proteins) is activated by Fip1 (show RRAGA Proteins)-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (show PDGFRA Proteins) (F/P) and is required for F/P stimulation of cellular proliferation and infiltration in chronic eosinophilic leukemia
Treatment with imatinib is associated with an excellent prognosis in FIP1L1-PDGFRA (show PDGFRA Proteins)-positive chronic eosinophilic leukemia in first chronic phase
FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
FIP1 like 1
, FIP1-like 1 protein
, pre-mRNA 3'-end-processing factor FIP1
, FIP1L1 cleavage and polyadenylation specific factor subunit
, factor interacting with PAP
, rearranged in hypereosinophilia