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FIP1L1 Proteins

(FIP1 Like 1 (FIP1L1))

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].

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FIP1L1 Protein (AA 1-378) (GST tag) (ABIN1354102)

FIP1L1 Origin: Human Host: Wheat germ Recombinant AA, AP, ELISA, WB

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FIP1L1 Proteins by Origin

Find FIP1L1 Proteins for a variety of species such as anti-Human FIP1L1. The species listed below are among those available. Click on a link to go to the corresponding products.

FIP1L1 Proteins by Source

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FIP1L1 Proteins by Protein Type

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FIP1L1 Proteins by Application

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Popular FIP1L1 Proteins

Product

Reactivity

Source

Validations

Cat. No.

Quantity

Datasheet

FIP1L1 Protein (AA 1-378) (GST tag)

Reactivity Human

Source Wheat germ

Validations

Cat. No. ABIN1354102

Quantity 10 μg

Datasheet Datasheet

Aliases for FIP1L1 Proteins

factor interacting with PAPOLA and CPSF1 (fip1l1) Proteins
factor interacting with PAPOLA and CPSF1 (FIP1L1) Proteins
factor interacting with PAPOLA and CPSF1 S homeolog (fip1l1.S) Proteins
factor interacting with PAPOLA and CPSF1 (Fip1l1) Proteins
FIP1 like 1 (S. cerevisiae) (Fip1l1) Proteins
FIP1 like 1b (S. cerevisiae) (fip1l1b) Proteins
1300019H17Rik Proteins
FIP1 Proteins
fip1l1 Proteins
hFip1 Proteins
Rhe Proteins
Rje Proteins
wu:fd36f11 Proteins
zgc:103421 Proteins

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