FIP1 Like 1 (S. Cerevisiae) Proteins (FIP1L1)

FIP1L1 encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. Additionally we are shipping FIP1 Like 1 (S. Cerevisiae) Antibodies (44) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
FIP1L1 81608 Q6UN15
Rat FIP1L1 FIP1L1 289582 Q5U317
FIP1L1 66899 Q9D824
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Top FIP1 Like 1 (S. Cerevisiae) Proteins at

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Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

FIP1L1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Interaction Partners

Human FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. Two identified variants revealed novel candidate genes for hip and knee osteoarthritis. OLIG3 and FIP1L1 have specific roles in transcription and may effect expression of other genes. Identified variants in these genes may thus have a role in the regulatory events leading to osteoarthritis.

  2. Herein, we report a case of a 53-year-old man with eosinophilia and a well-differentiated extramedullary myeloid tumor with evidence of FIP1L1/PDGFRA rearrangement by fluorescent in situ hybridization in the extramedullary tissue.

  3. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation.

  4. Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1-PDGFRA gene fusion.

  5. FIP1L1/ PDGFRA associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.

  6. F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.

  7. FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.

  8. FP fusion gene favors secondary KIT mutations in MCs via growth and proliferation signals or that a yet unknown mechanism causes genomic instability with independent evolution of FP and KIT D816V

  9. Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia.

  10. description of polycythemia vera concurrent with FIP1L1-PDGFRA-positive myeloproliferative neoplasm with eosinophilia [case report]

  11. Data show that the cyclin-dependent kinase 7/9 inhibitor (CDK7/9 inhibitor) potently inhibits FIP1L1-PDGFRalpha-positive Bcr-Abl-positive chronic myeloid leukemia (CML) cells.

  12. results strongly suggest that JAK2 is activated by Fip1-like1 (FIP1L1)-platelet-derived growth factor receptor alpha (F/P) and is required for F/P stimulation of cellular proliferation and infiltration in chronic eosinophilic leukemia

  13. Treatment with imatinib is associated with an excellent prognosis in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia in first chronic phase

  14. FIP1L1/PDGFRA fusion gene-positive myeloproliferative disorders with eosinophilia are discussed.

  15. The hypereosinophilic syndrome may result from a novel fusion tyrosine kinase - FIP1L1-PDGFRalpha - that is a consequence of an interstitial chromosomal deletion.

  16. observations suggest that the FIP1L1-PDGFRA rearrangement occurs in an early hematopoietic progenitor and suggests that the molecular pathogenesis for a subset of SMCD patients is similar to that of HES

  17. results indicate that the fusion of FIP1L1 to PDGFRA occurs rarely in leukemia cell lines

  18. FIP1L1-PDGFRA is a relatively infrequent but treatment-relevant mutation in primary eosinophilia that is indicative of an underlying systemic mastocytosis.

  19. the newly identified hFip1 protein, which has been shown to enhance polyadenylation through U-rich upstream elements, interacted specifically with the HPV-16 upstream element.

  20. Fusion protein is detected in hypereosinophilic syndrome and chronic eosinophilic leukemia.

Mouse (Murine) FIP1 Like 1 (S. Cerevisiae) (FIP1L1) interaction partners

  1. FIP1L1-PDGFRalpha activation requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent

FIP1 Like 1 (S. Cerevisiae) (FIP1L1) Protein Profile

Protein Summary

This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with FIP1L1

  • factor interacting with PAPOLA and CPSF1 (fip1l1)
  • factor interacting with PAPOLA and CPSF1 (FIP1L1)
  • factor interacting with PAPOLA and CPSF1 S homeolog (fip1l1.S)
  • factor interacting with PAPOLA and CPSF1 (Fip1l1)
  • FIP1 like 1 (S. cerevisiae) (Fip1l1)
  • FIP1 like 1b (S. cerevisiae) (fip1l1b)
  • 1300019H17Rik protein
  • FIP1 protein
  • fip1l1 protein
  • hFip1 protein
  • Rhe protein
  • Rje protein
  • wu:fd36f11 protein
  • zgc:103421 protein

Protein level used designations for FIP1L1

FIP1 like 1 , FIP1-like 1 protein , pre-mRNA 3'-end-processing factor FIP1 , FIP1L1 cleavage and polyadenylation specific factor subunit , factor interacting with PAP , rearranged in hypereosinophilia

733481 Xenopus (Silurana) tropicalis
100172699 Pongo abelii
81608 Homo sapiens
494780 Xenopus laevis
289582 Rattus norvegicus
422754 Gallus gallus
612980 Canis lupus familiaris
100138550 Bos taurus
66899 Mus musculus
450021 Danio rerio
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