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FIP1L1 Products

(FIP1 Like 1 (FIP1L1))

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This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008].

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Featured FIP1L1 Categories

FIP1L1 Antibodies

High quality antibodies with extensive validation data.

FIP1L1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FIP1L1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN7263123
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC, IF
Validations
  • (5)
Cat. No. ABIN6140640
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN529371
Quantity 100 μg
Datasheet Datasheet

Recommended FIP1L1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6228423
Quantity 96 tests
Datasheet Datasheet

Recommended FIP1L1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1354102
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our FIP1L1 products

Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).

Synonyms and alternative names related to FIP1L1

factor interacting with PAPOLA and CPSF1 (fip1l1), factor interacting with PAPOLA and CPSF1 (FIP1L1), factor interacting with PAPOLA and CPSF1 S homeolog (fip1l1.S), factor interacting with PAPOLA and CPSF1 (Fip1l1), FIP1 like 1 (S. cerevisiae) (Fip1l1), FIP1 like 1b (S. cerevisiae) (fip1l1b), 1300019H17Rik, FIP1, fip1l1, hFip1, Rhe, Rje, wu:fd36f11, zgc:103421

Protein level used designations for FIP1L1

  • FIP1 like 1
  • FIP1-like 1 protein
  • pre-mRNA 3'-end-processing factor FIP1
  • FIP1L1 cleavage and polyadenylation specific factor subunit
  • factor interacting with PAP
  • rearranged in hypereosinophilia
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