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The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping and FKBP5 Proteins (13) and many more products for this protein.
Showing 4 out of 16 products:
Trauma exposure shapes FKBP5 impact on schizophrenia.
The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking.
Study found that DNA methylation levels in multiple genomic regions of FKBP5, a regulator of glucocorticoid response sensitivity, does not mediate the relationship between childhood maltreatment (CM) and depression symptom severity; also a significant increase in FKBP5 gene expression (GE) levels associated with lifetime major depressive disorder, but found no significant difference in GE levels related to exposure to CM.
study thus provides support for an association between specific FKBP5 genetic variants and MDD risk
Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes.
The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of mediators of an internalizing pathway to problem drinking.
FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity.
Exposure to childhood physical abuse may increase the risk for sub-clinical depressive and anxiety symptoms depending on FKBP5 genetic variability.
SNPs moderate the association of positive and negative recent life events (LEs (show FUT3 ELISA Kits)) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits
In humans, abnormal fear extinction was associated with the TT homozygous genotype of FKBP5 SNPs RS9470080 and RS1360780, and hyperarousal symptoms. Results indicate that FKBP5 confers risk for abnormal fear extinction learning in humans, which may drive the development of arousal symptomatology and ultimately the development of posttraumatic stress disorder.
Fkbp5 knockouts are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. We identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160.
High FKBP5 expression is associated with anxiety/depression.
In mice, dexamethasone 300 mug/kg was associated with increased amygdala Fkbp5 mRNA following fear extinction and robust extinction learning while lower doses were not associated with amygdala Fkbp5 mRNA or differences in extinction learning. Further, mice that extinguished on dexamethasone 300 mug/kg maintained low levels of freezing behavior during recall training while mRNA levels were no longer elevated.
These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 (show HSP90 ELISA Kits) cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.
Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.
important regulator of PPARgamma (show PPARG ELISA Kits) in white adipose tissue
FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice
findings show that miR (show MLXIP ELISA Kits)-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.
These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.
We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.
FK506 binding protein 5
, FK506-binding protein 5
, PPIase FKBP5
, peptidyl-prolyl cis-trans isomerase FKBP5
, 51 kDa FK506-binding protein 5
, 51 kDa FKBP
, 54 kDa progesterone receptor-associated immunophilin
, FF1 antigen
, HSP90-binding immunophilin
, T-cell FK506-binding protein
, androgen-regulated protein 6
, peptidylprolyl cis-trans isomerase
, 51 kDa FK506-binding protein