FK506 Binding Protein 5 (FKBP5) ELISA Kits

The protein encoded by FKBP5 is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Additionally we are shipping FKBP5 Antibodies (145) and FKBP5 Proteins (13) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FKBP5 2289 Q13451
FKBP5 14229 Q64378
Anti-Rat FKBP5 FKBP5 361810  
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Top FKBP5 ELISA Kits at

Showing 2 out of 17 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.057 ng/mL 0.15 ng/mL - 10 ng/mL 96 Tests Log in to see 13 to 16 Days
Mouse < 0.061 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days

More ELISA Kits for FKBP5 Interaction Partners

Human FK506 Binding Protein 5 (FKBP5) interaction partners

  1. Study revealed that genetic variants in neonatal FKBP5 moderate the association between antenatal maternal depressive symptoms and right hippocampal volume but only show a trend for such moderation on amygdala volumes and cortical thickness.

  2. Our findings suggest that the FKBP5 gene and its epigenetic changes could have influence on morphologic changes of several brain regions involved in emotion regulation, and that this process may be associated with the development of MDD.

  3. We hypothesize a role for FKBP51 as a prognostic marker for MF and suggest an involvement of this immunophilin in deregulated NF-jB pathway of this CTCL.

  4. Trauma exposure shapes FKBP5 impact on schizophrenia.

  5. The present findings suggest that Fkbp5 expression in mesocorticolimbic dopaminergic regions associates with early life stress-mediated sensitivity to alcohol drinking and that FKBP5 genotype interacts with parent-child relationship to influence alcohol drinking.

  6. Study found that DNA methylation levels in multiple genomic regions of FKBP5, a regulator of glucocorticoid response sensitivity, does not mediate the relationship between childhood maltreatment (CM) and depression symptom severity; also a significant increase in FKBP5 gene expression (GE) levels associated with lifetime major depressive disorder, but found no significant difference in GE levels related to exposure to CM.

  7. study thus provides support for an association between specific FKBP5 genetic variants and MDD risk

  8. Methylation of FKBP5 is sensitive to stress exposure and may be a mechanism linking early adversity to long-term health and developmental outcomes.

  9. The results indicate that individuals with at least one copy of the FKBP5 CATT haplotype (minor alleles) are more vulnerable to traversing the hypothesized internalizing pathway of risk than individuals without this genotypic profile. Findings highlight the importance of FKBP5 genetic variation in the context of early adversity; support the role of mediators of an internalizing pathway to problem drinking.

  10. FKBP5 methylation mediated the association between early life stress and inhibition-related prefrontal activity.

  11. Exposure to childhood physical abuse may increase the risk for sub-clinical depressive and anxiety symptoms depending on FKBP5 genetic variability.

  12. SNPs moderate the association of positive and negative recent life events (LEs) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits

  13. In humans, abnormal fear extinction was associated with the TT homozygous genotype of FKBP5 SNPs RS9470080 and RS1360780, and hyperarousal symptoms. Results indicate that FKBP5 confers risk for abnormal fear extinction learning in humans, which may drive the development of arousal symptomatology and ultimately the development of posttraumatic stress disorder.

  14. It is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer.

  15. These results provide strong evidence of interactions between FKBP5 genotypes and early-life stress, which could pose a significant risk factor for stress-associated disorders such as major depression and post-traumatic stress disorder (PTSD).

  16. FKBP5 polymorphisms in combination with early life stress exposure predict higher insulin and glucose values in midlife.

  17. GxE interaction between child maltreatment and FKBP5 on dissociative symptoms in adolescence.

  18. Children with high attachment insecurity and homozygous FKBP5 minor alleles manifest maladaptive emotion regulation and depressive symptoms.

  19. This study demonstrated that FKBP5 Messenger RNA Increases After Adolescence in Human Dorsolateral Prefrontal Cortex.

  20. A novel FKBP5 1V55L mutation is associated with Paget's disease in a Chinese family. Mutant FKBP51V55L promotes osteoclastogenesis.

Mouse (Murine) FK506 Binding Protein 5 (FKBP5) interaction partners

  1. Fkbp5 knockouts are protected from high-fat diet-induced weight gain, show improved glucose tolerance and increased insulin signaling in skeletal muscle. We identify a novel association between FKBP51 and AS160, a substrate of AKT2 that is involved in glucose uptake. FKBP51 antagonism increases the phosphorylation of AS160.

  2. High FKBP5 expression is associated with anxiety/depression.

  3. In mice, dexamethasone 300 mug/kg was associated with increased amygdala Fkbp5 mRNA following fear extinction and robust extinction learning while lower doses were not associated with amygdala Fkbp5 mRNA or differences in extinction learning. Further, mice that extinguished on dexamethasone 300 mug/kg maintained low levels of freezing behavior during recall training while mRNA levels were no longer elevated.

  4. These data establish SUMO conjugation as a novel regulatory mechanism in the Hsp90 cochaperone activity of FKBP51 with a functional impact on GR signaling in a neuronal context.

  5. Findings indicate a role of FK506 binding protein 5 (FKBP5) in hypoxia-regulated adipogenesis.

  6. important regulator of PPARgamma in white adipose tissue

  7. FKBP5 might increase muscle mass through the enhancements of muscle protein synthesis and myotube differentiation as well as an inhibition of muscle protein degradation in mice

  8. findings show that miR-511 is a functional regulator of FKBP5 and can contribute to neuronal differentiation.

  9. These results suggest that the association between FKBP5 and alcohol consumption is conserved in both mice and humans.

  10. We discovered that the suggested psychiatric risk factor FK506 binding protein 51 (FKBP51) increases phosphorylation of GSK3beta at serine 9 (pGSK3beta(S9)).

  11. Results suggest that regulation of Fkbp5 mRNA expression via DNA methylation, and its subsequent regulation of glucocorticoid receptor sensitivity may be implicated in the molecular mechanisms of fear retention and extinciton

  12. the abundance of BDNF positively correlated and phosphorylated DNMT1 inversely correlated with that of FKBP51 in cells

  13. FKBP5 associates with BECN1, changes its phosphorylation and protein levels and enhances markers of autophagy and autophagic flux

  14. Aged animals display elevated FKBP51 levels, which contribute to impaired resiliency to depressive-like behaviors through impaired glucocorticoid signaling, a phenotype that is abrogated in FKBP5-/- mice.

  15. Overexpression of FKBP51 in the amygdala resulted in increased anxiety-related behavior.

  16. the stress response, as well as the effects of antidepressants on behavior and autophagic markers, depends on FKBP51.

  17. FKBP51 is a key regulator of adipogenesis via the Akt-p38 pathway.

  18. FKBP51 loss reciprocally regulates glucocorticoid receptor alpha and PPARgamma via 2 complementary mechanisms.

  19. In mice, the absence of the Fkbp5 gene enhances sensitivity to alcohol withdrawal.

  20. Higher levels of hypothalamic Fkbp5 expression were related to increased body weight gain. Fkbp5 may represent a novel target in metabolic regulation.

FKBP5 Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with FKBP5

  • FK506 binding protein 5 (FKBP5) antibody
  • FK506 binding protein 5 (fkbp5) antibody
  • FK506 binding protein 5 (Fkbp5) antibody
  • AIG6 antibody
  • D17Ertd592e antibody
  • Dit1 antibody
  • FKBP-5 antibody
  • FKBP5 antibody
  • FKBP51 antibody
  • FKBP54 antibody
  • P54 antibody
  • PPIase antibody
  • Ptg-10 antibody
  • si:zc263a23.8 antibody
  • wu:fc31g11 antibody
  • wu:fl87b03 antibody
  • zgc:64082 antibody

Protein level used designations for FKBP5

FK506 binding protein 5 , FK506-binding protein 5 , PPIase FKBP5 , peptidyl-prolyl cis-trans isomerase FKBP5 , rotamase , 51 kDa FK506-binding protein 5 , 51 kDa FKBP , 54 kDa progesterone receptor-associated immunophilin , FF1 antigen , FKBP-5 , FKBP-51 , HSP90-binding immunophilin , T-cell FK506-binding protein , androgen-regulated protein 6 , peptidylprolyl cis-trans isomerase , 51 kDa FK506-binding protein

462639 Pan troglodytes
100171536 Pongo abelii
100544523 Meleagris gallopavo
100551895 Anolis carolinensis
100591277 Nomascus leucogenys
2289 Homo sapiens
14229 Mus musculus
361810 Rattus norvegicus
368924 Danio rerio
421186 Gallus gallus
481759 Canis lupus familiaris
100155423 Sus scrofa
535704 Bos taurus
100339155 Oryctolagus cuniculus
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