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FKBP5 Products

(FK506 Binding Protein 5 (FKBP5))

Categories

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009].

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Featured FKBP5 Categories

FKBP5 Antibodies

High quality antibodies with extensive validation data.

FKBP5 ELISA Kits

Reliable ELISA kits for a wide range of species.

FKBP5 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended FKBP5 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application IF, IHC (p), WB
Validations
  • (3)
  • (6)
Cat. No. ABIN515669
Quantity 50 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, IHC
Validations
  • (6)
Cat. No. ABIN7260887
Quantity 200 μL
Datasheet Datasheet
Reactivity Human
Application IHC, WB
Validations
  • (4)
Cat. No. ABIN7267213
Quantity 100 μL
Datasheet Datasheet

Recommended FKBP5 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955923
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6955924
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4882891
Quantity 96 tests
Datasheet Datasheet

Recommended FKBP5 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1354130
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3080248
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3123299
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our FKBP5 products

Mata-Greenwood, Jackson, Pearce, Zhang: "Endothelial glucocorticoid receptor promoter methylation according to dexamethasone sensitivity." in: Journal of molecular endocrinology, (2015) (PubMed).

Romano, Xiao, Nakaya, DAngelillo, Chang, Jin, Hausch, Masullo, Feng, Romano, Sun: "FKBP51 employs both scaffold and isomerase functions to promote NF-?B activation in melanoma." in: Nucleic acids research, Vol. 43, Issue 14, pp. 6983-93, (2015) (PubMed).

Romano, DAngelillo, Staibano, Simeone, DArrigo, Ascierto, Scalvenzi, Mascolo, Ilardi, Merolla, Jovarauskaite, Romano: "Immunomodulatory pathways regulate expression of a spliced FKBP51 isoform in lymphocytes of melanoma patients." in: Pigment cell & melanoma research, Vol. 28, Issue 4, pp. 442-52, (2015) (PubMed).

Yang, Zhang, Pei, Xu, Li, Yu: "FK506-binding protein 5 inhibits proliferation and stimulates apoptosis of glioma cells." in: Archives of medical science : AMS, Vol. 11, Issue 5, pp. 1074-80, (2015) (PubMed).

Romano, DAngelillo, DArrigo, Staibano, Greco, Brunetti, Scalvenzi, Bisogni, Scala, Romano: "FKBP51 increases the tumour-promoter potential of TGF-beta." in: Clinical and translational medicine, Vol. 3, Issue 1, pp. 1, (2014) (PubMed).

Romano, Staibano, Greco, Brunetti, Nappo, Ilardi, Martinelli, Sorrentino, Di Pace, Mascolo, Bisogni, Scalvenzi, Alfano, Romano: "FK506 binding protein 51 positively regulates melanoma stemness and metastatic potential." in: Cell death & disease, Vol. 4, pp. e578, (2013) (PubMed).

van Lierop, Alkema, Laskewitz, Dijkema, van der Maaden, Smit, Plate, Conti, Jans, Timmers, van Boeckel, Lusher, McGuire, van Schaik, de Vlieg, Smeets, Hofstra, Boots, van Duin, Ingelse, Schoonen et al.: "Org 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic index. ..." in: PLoS ONE, Vol. 7, Issue 11, pp. e48385, (2012) (PubMed).

Horibe, Kohno, Haramoto, Ohara, Kawakami: "Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent." in: Journal of translational medicine, Vol. 9, pp. 8, (2011) (PubMed).

Synonyms and alternative names related to FKBP5

FK506 binding protein 5 (FKBP5), FK506 binding protein 5 (fkbp5), FK506 binding protein 5 (Fkbp5), AIG6, D17Ertd592e, Dit1, FKBP-5, FKBP5, FKBP51, FKBP54, P54, PPIase, Ptg-10, si:zc263a23.8, wu:fc31g11, wu:fl87b03, zgc:64082

Protein level used designations for FKBP5

  • FK506 binding protein 5
  • FK506-binding protein 5
  • PPIase FKBP5
  • peptidyl-prolyl cis-trans isomerase FKBP5
  • rotamase
  • 51 kDa FK506-binding protein 5
  • 51 kDa FKBP
  • 54 kDa progesterone receptor-associated immunophilin
  • FF1 antigen
  • FKBP-5
  • FKBP-51
  • HSP90-binding immunophilin
  • T-cell FK506-binding protein
  • androgen-regulated protein 6
  • peptidylprolyl cis-trans isomerase
  • 51 kDa FK506-binding protein
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