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Stimulates the proliferation of early hematopoietic cells by activating FLT3. Additionally we are shipping FMS-Like tyrosine Kinase 3 Ligand Kits (38) and FMS-Like tyrosine Kinase 3 Ligand Antibodies (7) and many more products for this protein.
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Intratumoral administration of the STING agonist cyclic di-GMP (show NT5C2 Proteins) (CDG) or Flt3 Ligand (Flt3L (show FLT3LG Proteins)) augmented the therapeutic effect of systemic triple checkpoint modulation and promoted the cure of 75% of mice with bilateral TRAMP (show DPT Proteins)-C2; however, when all agents were administered locally, only CDG mobilized abscopal immunity
both Flt3 ligand (FL (show FLT3LG Proteins)) and IL-7 (show IL7 Proteins) regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D (show LY6D Proteins)(+)CD135 (show FLT3 Proteins)(+)CD127 (show IL7R Proteins)(+)CD19 (show CD19 Proteins)(-) progenitors and IL-7 (show IL7 Proteins) by providing survival signals to these progenitors
Data show that FLT3 ligand (FLT3L (show FLT3LG Proteins)) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (show ATXN1 Proteins)(+)c-Kit(+) [LSK (show LCK Proteins)] cells via CXCR4 (show CXCR4 Proteins) receptor regulation.
these results demonstrate that the lack of Flt3L (show FLT3LG Proteins) mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells
this study shows that ionizing radiation induces a decrease of CD8 (show CD8A Proteins)+ dendritic cells and Th1 (show HAND1 Proteins)/Th2 shift, which was reversed by Flt3 ligand (show FLT3LG Proteins) treatment, suggesting a novel mechanism for radiation-induced immunosuppression
may be mediated by Flt3L (show FLT3LG Proteins)- and MMP-9 (show MMP9 Proteins)-dependent mobilization of dendritic cells
Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L (show FLT3LG Proteins).
Flt3L (show FLT3LG Proteins) significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
unlike G-CSF (show CSF3 Proteins), Flt3 (show FLT3 Proteins)-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors.
Study showed shown Flt3L (show FLT3LG Proteins)-dependent accumulation of a population of DNGR-1(CLEC9A (show CLEC9A Proteins))-EGFP+ CD45h CD11blow MHCII+ myeloid cells in the brain
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
, fms-related tyrosine kinase 3 ligand
, fms-like tyrosine kinase 3 ligand