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FUNDC1 encodes a protein with a FUN14 superfamily domain. Additionally we are shipping FUNDC1 Proteins (4) and FUNDC1 Kits (3) and many more products for this protein.
Showing 10 out of 70 products:
Cow (Bovine) Polyclonal FUNDC1 Primary Antibody for WB - ABIN2785323
Ross, Grafham, Coffey, Scherer, McLay, Muzny, Platzer, Howell, Burrows, Bird, Frankish, Lovell, Howe, Ashurst, Fulton, Sudbrak, Wen, Jones, Hurles, Andrews, Scott, Searle, Ramser, Whittaker, Deadman et al.: The DNA sequence of the human X chromosome. ... in Nature 2005
Show all 3 Pubmed References
phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy.
MARCH5 (show MARCH5 Antibodies) directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.
FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (show CRMP1 Antibodies) and calnexin (show CANX Antibodies) under hypoxic conditions in mammalian cells.
structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B (show MAP1LC3B Antibodies) and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.
FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.
The BCL2L1 (show BCL2L1 Antibodies)-PGAM5 (show PGAM5 Antibodies)-FUNDC1 axis is critical for receptor-mediated mitophagy.
FUNDC1 regulates ULK1 (show ULK1 Antibodies) recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 (show ULK1 Antibodies) is crucial for mitophagy.
Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1.
FUNDC1 binds to IP3R2 (show ITPR2 Antibodies) to modulate ER Ca(2 (show CA2 Antibodies)+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 (show ITPR2 Antibodies) interaction lowers the levels of Ca(2 (show CA2 Antibodies)+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure.
MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX (show BNIP3L Antibodies)
This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.
FUN14 domain-containing protein 1
, FUN14 domain-containing protein 1A