FUN14 Domain Containing 1 (FUNDC1) ELISA Kits

FUNDC1 encodes a protein with a FUN14 superfamily domain. Additionally we are shipping FUNDC1 Antibodies (96) and FUNDC1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FUNDC1 139341 Q8IVP5
FUNDC1 72018 Q9DB70
FUNDC1 363442 Q5BJS4
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Catalog No. Reactivity Sensitivity Range Images Quantity Delivery Price Details
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days
  96 Tests 15 to 18 Days

More ELISA Kits for FUNDC1 Interaction Partners

Human FUN14 Domain Containing 1 (FUNDC1) interaction partners

  1. Elevated FUNDC1 levelcould stimulate human breast cancer proliferation and migration via Ca2+influxas well as NFATC1 activation and translocation into the nucleus, whichfurther binds and activates BMI1 transcription. The positive relationshipbetween FUNDC1 and BMI1 expression further predicts worse progres-sion of breast cancer.

  2. Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy.

  3. phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy.

  4. MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.

  5. FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells.

  6. structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.

  7. FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.

  8. The BCL2L1-PGAM5-FUNDC1 axis is critical for receptor-mediated mitophagy.

  9. FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 is crucial for mitophagy.

  10. Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1.

Cow (Bovine) FUN14 Domain Containing 1 (FUNDC1) interaction partners

  1. We observed that both transcript and protein levels of FUNDC1 were decreased in bovine papillomavirus-infected neoplastic bladder cells.It is conceivable that FUNDC1 plays a central role in mitochondrion fragmentation via phosphorylated DRP1 as observed in our study.

Mouse (Murine) FUN14 Domain Containing 1 (FUNDC1) interaction partners

  1. results confirmed that CK2alpha serves as a negative regulator of mitochondrial homeostasis via suppression of FUNDC1-required mitophagy, favoring the development of cardiac IR injury.

  2. By facilitating Mff-mediated mitochondrial fission and FUNDC1-required mitophagy, NR4A1 disturbed mitochondrial homeostasis, enhanced endothelial apoptosis and provoked microvascular dysfunction in myocardial ischemia reperfusion injury.

  3. FUNDC1 is required for cardiac ischemia reperfusion injury activated mitophagy.

  4. hypoxic preconditioning induces FUNDC1-dependent mitophagy in platelets and reduces Ischemia/Reperfusion-induced heart injury, suggesting a new strategy to protect cardiac function and fight cardiovascular diseases.

  5. FUNDC1 binds to IP3R2 to modulate ER Ca(2+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 interaction lowers the levels of Ca(2+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure.

  6. MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX

FUNDC1 Antigen Profile

Antigen Summary

This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.

Gene names and symbols associated with FUNDC1

  • FUN14 domain-containing protein 1-like (LOC100357289) antibody
  • FUN14 domain containing 1 S homeolog (fundc1.S) antibody
  • FUN14 domain containing 1 (FUNDC1) antibody
  • FUN14 domain containing 1 (Fundc1) antibody
  • FUN14 domain containing 1 (fundc1) antibody
  • 1500005J14Rik antibody
  • 1810033P05Rik antibody
  • fundc1-a antibody
  • zgc:92600 antibody

Protein level used designations for FUNDC1

FUN14 domain-containing protein 1 , FUN14 domain-containing protein 1A

100357289 Oryctolagus cuniculus
734365 Xenopus laevis
418558 Gallus gallus
139341 Homo sapiens
491842 Canis lupus familiaris
518258 Bos taurus
72018 Mus musculus
363442 Rattus norvegicus
436984 Danio rerio
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