FUN14 Domain Containing 1 (FUNDC1) ELISA Kits

FUNDC1 encodes a protein with a FUN14 superfamily domain. Additionally we are shipping FUNDC1 Antibodies (70) and FUNDC1 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
FUNDC1 139341 Q8IVP5
FUNDC1 72018 Q9DB70
FUNDC1 363442 Q5BJS4
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Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
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More ELISA Kits for FUNDC1 Interaction Partners

Human FUN14 Domain Containing 1 (FUNDC1) interaction partners

  1. phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy.

  2. MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.

  3. FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (show CRMP1 ELISA Kits) and calnexin (show CANX ELISA Kits) under hypoxic conditions in mammalian cells.

  4. structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B (show MAP1LC3B ELISA Kits) and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.

  5. FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.

  6. The BCL2L1 (show BCL2L1 ELISA Kits)-PGAM5 (show PGAM5 ELISA Kits)-FUNDC1 axis is critical for receptor-mediated mitophagy.

  7. FUNDC1 regulates ULK1 (show ULK1 ELISA Kits) recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 (show ULK1 ELISA Kits) is crucial for mitophagy.

  8. Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1.

Mouse (Murine) FUN14 Domain Containing 1 (FUNDC1) interaction partners

  1. FUNDC1 binds to IP3R2 to modulate ER Ca(2 (show CA2 ELISA Kits)+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 interaction lowers the levels of Ca(2 (show CA2 ELISA Kits)+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure.

  2. MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX (show BNIP3L ELISA Kits)

FUNDC1 Antigen Profile

Antigen Summary

This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.

Gene names and symbols associated with FUNDC1

  • FUN14 domain-containing protein 1-like (LOC100357289) antibody
  • FUN14 domain containing 1 S homeolog (fundc1.S) antibody
  • FUN14 domain containing 1 (FUNDC1) antibody
  • FUN14 domain containing 1 (Fundc1) antibody
  • FUN14 domain containing 1 (fundc1) antibody
  • 1500005J14Rik antibody
  • 1810033P05Rik antibody
  • fundc1-a antibody
  • zgc:92600 antibody

Protein level used designations for FUNDC1

FUN14 domain-containing protein 1 , FUN14 domain-containing protein 1A

100357289 Oryctolagus cuniculus
734365 Xenopus laevis
418558 Gallus gallus
139341 Homo sapiens
491842 Canis lupus familiaris
518258 Bos taurus
72018 Mus musculus
363442 Rattus norvegicus
436984 Danio rerio
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