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FUNDC1 encodes a protein with a FUN14 superfamily domain.
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Our data suggested that FUNDC1 can be used as a prognostic biomarker in patients with cervical cancer, and may be a new therapeutic target to improve the antitumor effects of chemoradiotherapy.
phosphorylation of Tyr18 of FUNDC1 serves as a molecular switch for mitophagy.
MARCH5 directly interacts with FUNDC1 to mediate its ubiquitylation at lysine 119 for subsequent degradation.
FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the endoplasmic reticulum-mitochondrial contact site by working in concert with DRP1 (show CRMP1 ELISA Kits) and calnexin (show CANX ELISA Kits) under hypoxic conditions in mammalian cells.
structural and biochemical results reveal a working model for the specific recognition of FUNDC1 by LC3B (show MAP1LC3B ELISA Kits) and imply that the reversible phosphorylation modification of mitophagy receptors may be a switch for selective mitophagy.
FUNDC1 regulates both mitochondrial fission or fusion and mitophagy.
The BCL2L1 (show BCL2L1 ELISA Kits)-PGAM5 (show PGAM5 ELISA Kits)-FUNDC1 axis is critical for receptor-mediated mitophagy.
FUNDC1 regulates ULK1 (show ULK1 ELISA Kits) recruitment to damaged mitochondria, where FUNDC1 phosphorylation by ULK1 (show ULK1 ELISA Kits) is crucial for mitophagy.
Data show that Knockdown of endogenous FUNDC1 significantly prevented hypoxia-induced mitophagy, which could be reversed by the expression of wild-type FUNDC1.
FUNDC1 is required for cardiac ischemia reperfusion injury activated mitophagy.
hypoxic preconditioning induces FUNDC1-dependent mitophagy in platelets and reduces Ischemia/Reperfusion-induced heart injury, suggesting a new strategy to protect cardiac function and fight cardiovascular diseases.
FUNDC1 binds to IP3R2 to modulate ER Ca(2 (show CA2 ELISA Kits)+) release into mitochondria and cytosol. Disruption of the FUNDC1 and IP3R2 interaction lowers the levels of Ca(2 (show CA2 ELISA Kits)+) in mitochondria and cytosol, both of which instigate aberrant mitochondrial fission, mitochondrial dysfunction, cardiac dysfunction, and heart failure.
MicroRNA-137 has a role in inhibiting mitophagy via regulation of two mitophagy receptors FUNDC1 and NIX (show BNIP3L ELISA Kits)
This gene encodes a protein with a FUN14 superfamily domain. The function of the encoded protein is not known.
FUN14 domain-containing protein 1
, FUN14 domain-containing protein 1A