anti-Fanconi Anemia, Complementation Group C (FANCC) Antibodies

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping Fanconi Anemia, Complementation Group C Proteins (6) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FANCC 2176 Q00597
FANCC 14088  
FANCC 24361  
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Fanconi Anemia, Complementation Group C Antibodies at antibodies-online.com

Showing 10 out of 119 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB WB Image FANCC antibody detects FANCC protein by western blot analysis. Various whole cell extracts (30 μg) were separated by 7.5 % SDS-PAGE, and blotted with FANCC antibody , diluted by 1:1000 ICC/IF Image Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using FANCC, antibody at 1:200 dilution. 100 μL 3 to 4 Days
$466.18
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Immunofluorescence analysis of paraformaldehyde-fixed HeLa, merged with DNA probe, using FANCC antibody at 1:200 dilution. Immunofluorescence analysis of paraformaldehyde-fixed HeLa, using FANCC antibody at 1:200 dilution. 50 μL 6 to 8 Days
$495.00
Details
Human Rabbit Un-conjugated IF, IP, WB FANCC MaxPab rabbit polyclonal antibody. Western Blot analysis of FANCC expression in human kidney. Immunoprecipitation of FANCC transfected lysate using anti-FANCC MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with FANCC purified MaxPab mouse polyclonal antibody (B01P) . 100 μL 11 to 12 Days
$350.67
Details
Chimpanzee Rabbit Un-conjugated EIA, WB   0.1 mg 4 to 8 Days
$632.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Thymus: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with FANCC antibody ABIN214342 at 2.5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-FANCC antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 50 μg 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated ELISA, IHC, WB Western blot analysis of Hela whole cell lysates, using FANCC Antibody. The lane on the left is treated with the antigen-specific peptide. ABIN6276895 at 1/100 staining Mouse liver tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22¡ãC. An HRP conjugated goat anti-rabbit antibody was used as the secondary 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated EIA, FACS, IF, IHC (p), WB   0.4 mL 4 to 8 Days
$522.50
Details
Human Mouse Un-conjugated ELISA, IF, IHC, IHC (p), WB Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg 11 to 14 Days
$742.50
Details

Top referenced anti-Fanconi Anemia, Complementation Group C Antibodies

  1. Polyclonal FANCC Primary Antibody for WB - ABIN540662 : Freie, Ciccone, Li, Plett, Orschell, Srour, Hanenberg, Schindler, Lee, Clapp: A role for the Fanconi anemia C protein in maintaining the DNA damage-induced G2 checkpoint. in The Journal of biological chemistry 2004 (PubMed)

  2. Human Polyclonal FANCC Primary Antibody for WB - ABIN251003 : Yung, Tilgner, Ledran, Habibollah, Neganova, Singhapol, Saretzki, Stojkovic, Armstrong, Przyborski, Lako: Brief report: human pluripotent stem cell models of fanconi anemia deficiency reveal an important role for fanconi anemia proteins in cellular reprogramming and survival of hematopoietic progenitors. in Stem cells (Dayton, Ohio) 2013 (PubMed)

  3. Human Polyclonal FANCC Primary Antibody for ELISA, ICC - ABIN4310504 : Moeller, Yordy, Williams, Giri, Raju, Molkentine, Byers, Heymach, Story, Lee, Sturgis, Weber, Garden, Ang, Schwartz: DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. in Clinical cancer research : an official journal of the American Association for Cancer Research 2011 (PubMed)

More Antibodies against Fanconi Anemia, Complementation Group C Interaction Partners

Human Fanconi Anemia, Complementation Group C (FANCC) interaction partners

  1. This study showed that featured-metabolic alterations are readouts of functional mechanisms underlying reduced tumorigenicity driven by FANCC, demonstrating close links among cancer, aging, inflammation and DM.

  2. The splice-site mutation in the FANCC gene (IVS4+4A>T) accounts for most cases of Fanconi anaemia in Ashkenazi Jewish cohorts worldwide.A founder mutation described in individuals of Ashkenazi Jewish ancestry is also found in South African individuals of this origin.

  3. mutation IVS4+4A>T is the most prevalent mutation in our group of patients. This analysis of Pakistani patients also suggests that there is no significant difference between IVS4+4A>T homozygotes and the rest of the patients with regard to severity of clinical phenotype.

  4. The finding that FANCC overexpression reduced betacell apoptosis advances the potential for an alternative approach to the treatment of Diabetes mellitus caused by FANCC defects

  5. Lung adenocarcinomas in both male and female patients were associated with (a) genotypic polymorphisms of FANCC and FANCD1.

  6. Israeli ATM, BLM, and FANCC heterozygous mutation carriers are not at an increased risk for developing cancer.

  7. FANCC interacts and co-localizes with STMN1 at centrosomes during mitosis. We also showed that FANCC is required for STMN1 phosphorylation.

  8. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A.

  9. The successful in vitro repair of the mutated Fanconi anemia FANCC gene using the CRISPR/Cas9 system has been described.

  10. Data indicate that TLR-induced IL-1beta overproduction in FANCA- and FANCC-deficient mononuclear phagocyte cell lines and primary cells requires activation of the inflammasome.

  11. deregulations of the FANCC-mediated DNA damage repair pathway and the PTCH1-associated sonic hedgehog pathway are associated with the development of early dysplastic head and neck lesions.

  12. we identified faults in two genes, Fanconi C and Bloom helicase( FANCC and BLM), in six families. Faults in these genes appear to increase the risk of developing breast cancer

  13. FANCC polymorphisms might be associated with the obstructive symptoms in allergic diseases.

  14. FA DNA repair genes, FANCD2, FANCL, and FANCC, are transcriptionally upregulated differently in melanoma compared with non-melanoma skin cancer

  15. genetic diversity in FANCA, FANCC and FANCL does not support an association of these genes with cervical cancer susceptibility in the Swedish population.

  16. Cytoplasmic FANCA-FANCC complex was essential for NPMc stability.

  17. Correct mRNA processing at a mutant TT splice donor in FANCC ameliorates the clinical phenotype in Fanconi anemia patients and is enhanced by delivery of suppressor U1 snRNAs.

  18. we identified a hepatocellular carcinoma cell line harboring an inactivating mutation of the FANCC gene, specifically causing proximal FA pathway inactivation and the classic cellular DNA interstrand-crosslinking agents-hypersensitivity phenotype

  19. study found genetic interaction between Fanconi anemia(FA)gene FANCC and Ku70; results indicate FA pathway promotes homologous recombination repair of DNA double-strand breaks (DSBs) by counteracting Ku70; suggest this achieved by modification of DSBs

  20. The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of this protein.

Mouse (Murine) Fanconi Anemia, Complementation Group C (FANCC) interaction partners

  1. TP53 haploinsufficiency completely rescues emergency granulopoiesis in FANCC(-/-) mice.

  2. Genetic deletion of Fancc blocks the autophagic clearance of viruses (virophagy) and increases susceptibility to lethal viral encephalitis. Fanconi anemia complementation group C (FANCC) protein interacts with Parkin, is required in vitro and in vivo for clearance of damaged mitochondria, and decreases mitochondrial reactive oxygen species (ROS) production and inflammasome activation.

  3. Data show that Fanconi anemia, complementation group C protein knockout (Fancc -/-) mice develop hematopoietic chromosomal instability followed by leukemia in an age-dependent manner.

  4. Loss of Fancc Impairs Antibody-Secreting Cell Differentiation in Mice through Deregulating the Wnt Signaling Pathway

  5. Combined deficiency of Foxo3a and Fancc or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.

  6. Using mice deficient in both Mus81 and the FA pathway protein FancC, we show both proteins cooperate in parallel pathways, as concomitant loss of FancC and Mus81 triggered cell-type-specific proliferation arrest, apoptosis and DNA damage accumulation in utero.

  7. Loss of FANCC leads to a drastic increase in stalled/collapsed forks in cells carrying an Mcm4 missense mutation.

  8. FANCC is most likely to be critical for resistance to DNA cross-linking drug-induced DNA damage in cells transformed by JAK2 V617F mutant.

  9. Data indicate that IL-1beta overproduction from FANCC-deficient macrophages is p38 dependent.

  10. Loss of FANCC expression results in an impaired emergency granulopoiesis response in a transgenic mouse model of Fanconi anemia.

  11. Compromised hematopoiesis in Fancc(-/-) animals is developmentally programmed and does not arise de novo in bone marrow.

  12. Double-mutant Fancc(-/-);Fancg(-/-) mice develop spontaneous hematologic sequelae including bone marrow failure, acute myeloid leukemia, myelodysplasia and complex random chromosomal abnormalities that the single-mutant mice do not.

  13. Fancc deficiency accelerates telomere shortening during high turnover of hematopoietic cells and promotes telomere recombination initiated by short telomeres.

  14. The results support a model where both FANCA and FANCC are part of a multi-protein nuclear FA complex with identical function in cellular responses to DNA damage and germ cell survival.

  15. whereas Fancc-/- mice failed to form hematopoietic or solid malignancies, mice mutant at both Fancc and Trp53 developed tumors more rapidly than mice mutant at Trp53 alone.

  16. Fancc mutations result in a subtle immunological defect owing to the failure of FANCC to normally support Janus kinase/STAT signaling, such that differentiation of Fancc-/- CD4+ T cells into the Th1 subset is impaired in Fancc-deficient mice.

  17. the intrinsic defects in the genomic stability of Fancc(-/-) stem/progenitor cells provide a selective pressure for cells that are resistant to apoptosis and have a propensity for the evolution to clonal hematopoiesis and malignancy

  18. predisposition of Fancc-/- hematopoietic progenitors to apoptosis is mediated in part through altered redox regulation and apoptosis signal-regulating kinase 1 hyperactivation

  19. Data suggest that TNF-alpha exposure creates an environment in which somatically mutated preleukemic stem cell clones are selected and from which unaltered TNF-alpha-hypersensitive Fancc-/- stem cells are purged.

  20. Short-term transduction of c-kit(+) cells with a foamyviral vector is sufficient for functional correction of a stem cell phenotype in a murine Fanconi anemia model.

Fanconi Anemia, Complementation Group C (FANCC) Antigen Profile

Protein Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C.

Gene names and symbols associated with FANCC

  • Fanconi anemia complementation group C (FANCC) antibody
  • Fanconi anemia, complementation group C (fancc) antibody
  • Fanconi anemia complementation group C L homeolog (fancc.L) antibody
  • Fanconi anemia, complementation group C (Fancc) antibody
  • BB116513 antibody
  • FA3 antibody
  • FAC antibody
  • Facc antibody
  • FANCC antibody
  • zgc:154105 antibody

Protein level used designations for FANCC

Fanconi anemia, complementation group C protein , Fanconi anemia C , Fanconi anemia, complementation group C , fanconi anemia group C protein-like , Fanconi anemia group C protein-like , Fanconi anemia group C protein , Fanconi anemia group C protein homolog

GENE ID SPECIES
427468 Gallus gallus
692127 Danio rerio
709398 Macaca mulatta
100061359 Equus caballus
100329211 Xenopus laevis
100344788 Oryctolagus cuniculus
100409306 Callithrix jacchus
100461880 Pongo abelii
2176 Homo sapiens
465257 Pan troglodytes
14088 Mus musculus
24361 Rattus norvegicus
281762 Bos taurus
607277 Canis lupus familiaris
Selected quality suppliers for anti-Fanconi Anemia, Complementation Group C (FANCC) Antibodies
Did you look for something else?