anti-Fanconi Anemia, Complementation Group D2 (FANCD2) Antibodies

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCD2 Kits (9) and and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
FANCD2 2177 Q9BXW9
FANCD2 211651 Q80V62
FANCD2 312641 Q6IV68
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Top anti-FANCD2 Antibodies at antibodies-online.com

Showing 10 out of 179 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated FACS, ICC, IF, IHC, IHC (p), IP, RNAi, SimWes, WB FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h.  Images were captured in a Kodak digital image system on a Leica fluorescence microscope. FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. 0.05 mL Log in to see 7 to 9 Days
$516.98
Details
Dog Rabbit Biotin ICC, IF, IHC, IHC (p), WB FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. 0.05 mL Log in to see 7 to 9 Days
$629.98
Details
Dog Rabbit HRP IHC, IHC (p), WB FancD2 colocalizes in vivo with another protein in SiHa cells after cell exposure to IR. Proliferating SiHa cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. FancD2 colocalizes in vivo with another protein in U2OS cells after cell exposure to IR. Proliferating U2OS cells were exposed to 10 Gy of IR and double -color immunofluorescence staining was performed after 8 h. Images were captured in a Kodak digital image system on a Leica fluorescence microscope. 0.05 mL Log in to see 7 to 9 Days
$658.23
Details
Human Mouse Un-conjugated ChIP, IP, SimWes, WB Simple Western: FANCD2 Antibody (FI-17) [ABIN151782] - Simple Western lane view shows a specific band for FANCD2 in 1.0 mg/ml of HeLa lysate. This experiment was performed under reducing conditions using the 12-230 kDa separation system. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Horse Rabbit Un-conjugated WB Host: Rabbit Target Name: FANCD2 Sample Type: NCI-H226 Whole Cell lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Indicated lymphoblasts (PD7, WT: GM1526, AT) were irradiated with 15 Gy (2), and immunoblotted with anti-FANCD2 and anti-FANCD2 (pS-222), cat# ABIN151945. 0.2 mL Log in to see 7 to 9 Days
$418.10
Details
Human Rabbit Un-conjugated IF, IHC, WB Immunofluorescence analysis of A549 cell using FANCD2 antibody. 100 μL Log in to see 11 to 13 Days
$366.77
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HT29 cells treated with Calyculin A 50ng/ml 30', using FANCD2 (Phospho-Ser222) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human lung carcinoma, using FANCD2 (Phospho-Ser222) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HT-29 cells, treated with Calyculin A 50ng/ml 30', using FANCD2 (Ab-222) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using FANCD2 (Ab-222) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see Available
$363.46
Details

Top referenced anti-FANCD2 Antibodies

  1. Dog (Canine) Polyclonal FANCD2 Primary Antibody for FACS, ICC - ABIN151329 : Bekker-Jensen, Lukas, Kitagawa, Melander, Kastan, Bartek, Lukas: Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. in The Journal of cell biology 2006 (PubMed)
    Show all 137 Pubmed References

  2. Human Monoclonal FANCD2 Primary Antibody for ChIP, IP - ABIN151782 : Nomura, Adachi, Koyama: Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. in Genes to cells : devoted to molecular & cellular mechanisms 2007 (PubMed)
    Show all 11 Pubmed References

  3. Dog (Canine) Polyclonal FANCD2 Primary Antibody for ICC, IF - ABIN250520 : Garcia-Higuera, Taniguchi, Ganesan, Meyn, Timmers, Hejna, Grompe, DAndrea: Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway. in Molecular cell 2001 (PubMed)
    Show all 15 Pubmed References

  4. Dog (Canine) Polyclonal FANCD2 Primary Antibody for IHC, IHC (p) - ABIN250521 : Rothfuss, Grompe: Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. in Molecular and cellular biology 2003 (PubMed)
    Show all 15 Pubmed References

  5. Polyclonal FANCD2 Primary Antibody for IHC (fro), IF - ABIN540721 : Stiff, Reis, Alderton, Woodbine, ODriscoll, Jeggo: Nbs1 is required for ATR-dependent phosphorylation events. in The EMBO journal 2005 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal FANCD2 Primary Antibody for IHC - ABIN966127 : Kweekel, Antonini, Nortier, Punt, Gelderblom, Guchelaar: Explorative study to identify novel candidate genes related to oxaliplatin efficacy and toxicity using a DNA repair array. in British journal of cancer 2009 (PubMed)
    Show all 6 Pubmed References

  7. Monoclonal FANCD2 Primary Antibody for IP, WB - ABIN534121 : Park, Ciccone, Beck, Hwang, Freie, Clapp, Lee: Oxidative stress/damage induces multimerization and interaction of Fanconi anemia proteins. in The Journal of biological chemistry 2004 (PubMed)
    Show all 4 Pubmed References

  8. Human Polyclonal FANCD2 Primary Antibody for WB - ABIN151945 : Taniguchi, Garcia-Higuera, Xu, Andreassen, Gregory, Kim, Lane, Kastan, DAndrea: Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. in Cell 2002 (PubMed)
    Show all 2 Pubmed References

More Antibodies against FANCD2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.

  2. Fancd2 has a role in DNA repair.

Xenopus laevis Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. study showed that FANCI-FANCD2 is required for replication-coupled DNA interstrand cross-link (ICL) repair in S phase; results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia pathway is compromised

  2. The Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathways.

Silk Worm Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. silkworm cells deficient for FA proteins FancD2 and FancM exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT)

  2. It was shown that silkworm FancD2 is monoubiquitinated depending on FancI and FancL, and stabilized on chromatin, following mitomycin C. Depletion of FancD2, FancI or FancL effected cell proliferation in the presence of mitomycin C.

Human Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. E6 expression caused delayed FancD2 de-ubiquitination, an important process for effective ICL repair. Delayed FancD2 de-ubiquitination was associated with the increased chromatin retention of FancD2 hindering USP1 de-ubiquitinating activity, and persistently activated ATR/CHK-1/pS565 FancI signaling.

  2. The ability of SETD1A to prevent degradation of these structures is mediated by its ability to catalyze methylation on Lys4 of histone H3 (H3K4) at replication forks, which enhances FANCD2-dependent histone chaperone activity.

  3. The study demonstrates a novel role of FANCD2 in governing cellular ATP production via ATP5A, and advances the understanding of how defective Fanconi anemia signaling contributes to aging and cancer at the energy metabolism level.

  4. Study reports the first structural insight into the human FANCD2-FANCI complex by obtaining the cryo-EM structure. The complex contains an inner cavity, large enough to accommodate a double-stranded DNA helix, as well as a protruding Tower domain. Disease-causing mutations in the Tower domain are observed in several Fanconi anemia patients.

  5. Our results indicate a potential role in breast cancer predisposition for heterozygous truncating mutations in FANCD2 and TEX15. Based on our results, FANCD2 c.2715 + 1G > A might act as a moderate breast cancer risk allele, adding FANCD2 to the list of shared genes between FA and breast cancer.

  6. demonstrate that the FANC pathway acts downstream MiTF and establish the existence of an epistatic relationship between MiTF and the FANC pathway

  7. we discuss the recent and relevant studies to provide an updated review on the roles of FANCD2 in the DNA damage response.

  8. FANCI phosphorylation activates the FANCI/D2 complex.

  9. FANCD2 and PALB2, as indicators of the upstream and downstream arms, respectively, colocalize independently of each other in response to DNA damage.

  10. FANCD2 has a ubiquitination-independent role in countering endogenous levels of replication stress, a function that is critical for the maintenance of genomic stability.

  11. Data suggest that FANCI and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response.

  12. Fanconi anemia FANCD2 and FANCI proteins regulate the nuclear dynamics of splicing factors, such as SF3B1.

  13. People with Fanconi anemia, or healthy people who develop sporadic mutations in FANCD2, may be hypersensitive to the carcinogenic activity of coffee.

  14. Results indicate the importance of DNA binding and nuclear localization sequences (NLS) residues in Fanconi Anemia Group D2 Protein (FANCD2) to activate an efficient Fanconi anemia (FA) pathway.

  15. FANCB dimer coordinates FANCD2:FANCI monoubiquitination by two FANCL RING-ligases. Deubiquitination of FANCD2:FANCI by USP1:UAF1 occurs only when DNA is removed.

  16. These results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.

  17. these findings provide a previously unrecognized central player FANCD2-V2 and thus novel insights into human tumorigenesis, and indicate that V2/V1 can act as an effective biomarker in assisting the recognition of tumor malignance

  18. The data demonstrate that FANCD2 protein is required to ensure efficient chromosome fragile sites (CFS) replication and provide mechanistic insight into how FANCD2 regulates CFS stability.

  19. A breakdown in a BRCA/FANCD2/BRG1/SNF-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.

  20. High FANCD2 expression is associated with drug Resistance in Malignant Melanoma.

Mouse (Murine) Fanconi Anemia, Complementation Group D2 (FANCD2) interaction partners

  1. Data indicate that linker of T-cell receptor pathways protein(Lnk) deficiency restores phenotypic hematopoietic stem cells (HSCs) in Fanconi anemia, complementation group D2 protein knockout (Fancd2-/-) mice.

  2. Fancd2 localizes in the mitochondrion and associates with the nucleoid complex components Atad3 and Tufm.

  3. Data show that stromal cell lines derived from both K14E7 Fancd2-/- and Fancd2-/- cultures were radiosensitive.

  4. Fancd2-/- mice exhibit a pervasive developmental HSPC defect that echoes the constitutional defects evident at birth in a subset of FA patients.

  5. loss of Fancd2 yields significant defects to fetal liver hematopoiesis, particularly the HSC population, which mimics key phenotypes from adult Fancd2 KO bone marrow independently of aging-accrued DNA damage.

  6. Data that suggest Usp1 (ubiquitin specific peptidase 1) down-regulation by autocleavage is critical for Usp1 to exert role in DNA interstrand crosslink repair; Usp1 role is de-ubiquitination of Fancd2 and Pcna (proliferating cell nuclear antigen).

  7. recruitment of Fan1 by ubiquitinated-Fancd2 is dispensable for DNA interstrand cross-links repair

  8. Results show that FANCD2 and ADH5 protect hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage resulting from accumulation of endogenous formaldehyde.

  9. Combined deficiency of Foxo3a and Fancc or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.

  10. Data demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a and for maintaining hematopoietic repopulation of the HSCs.

  11. E7 induces human papillomavirus-associated head and neck cancers by promoting DNA damage through the inactivation of pocket proteins.

  12. CD25(+)Foxp3(+) Tregs of Fanca(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.

  13. Fancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis.

  14. Studies indicate that in Fancd2-Knockout mice, the formation of sex-cords and intraovarian tubules lead to the formation of tumours with multiple phenotypes including luteomas, papillary cysts and malignant carcinomas.

  15. the Fanconi anaemia DNA repair pathway counteracts acetaldehyde-induced genotoxicity in mice; Aldh2(-/-)Fancd2(-/-) mice spontaneously develop acute leukaemia

  16. crystal structure of FANCI-FANCD2(ID) complex; crystallographic electron-density map of FANCI protein bound to splayed Y DNA; data suggest ID complex recognizes DNA structures resulting from encounter of replication forks with an interstrand cross-link

  17. Data show that Fancd2(-/-) mice displayed a higher magnitude of chromosomal breakage and micronucleus formation than the wild-type or Fancg(-/-) mice.

  18. Data sshow that K14E7/FancD2(-/-) mice had a significantly higher incidence of HNSCC compared with K14E7/FancD2(+/+) mice.

  19. Bone marrow from Fancd2-/- mice and Usp1-/- mice exhibited marked hematopoietic defects.

  20. found that C/EBPdelta promotes monoubiquitination of the Fanconi anemia complementation group D2 protein (FANCD2), which is necessary for its function in replication-associated DNA repair

FANCD2 Antigen Profile

Protein Summary

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.

Gene names and symbols associated with FANCD2

  • Fanconi anemia complementation group D2 (FANCD2) antibody
  • CG17269 gene product from transcript CG17269-RA (Fancd2) antibody
  • Fanconi anemia group D2 protein (LOC100455970) antibody
  • Fanconi anemia complementation group D2 (fancd2) antibody
  • Fanconi anemia, complementation group D2 (fancd2) antibody
  • Fanconi anemia complementation group D2 L homeolog (fancd2.L) antibody
  • Fanconi anemia, complementation group D2 (FANCD2) antibody
  • Fanconi anemia, complementation group D2 (Fancd2) antibody
  • 2410150O07Rik antibody
  • AU015151 antibody
  • BB137857 antibody
  • CG17269 antibody
  • CG31192 antibody
  • CG31194 antibody
  • Dmel\\CG17269 antibody
  • dmFANCD2 antibody
  • FA-D2 antibody
  • FA4 antibody
  • FACD antibody
  • FAD antibody
  • FAD2 antibody
  • FANCD antibody
  • FANCD2 antibody
  • xfancd2 antibody

Protein level used designations for FANCD2

Fanconi anemia, complementation group D2 , CG17269-PA , Fancd2-PA , Fanconi anemia group D2 protein-like , fanconi anemia protein FANCD2 , Fanconi anemia complementation group D2 , Fanconi anemia group D2 protein , Fanconi anemia group D2 protein homolog , Fanconi anemia D2 protein

GENE ID SPECIES
460163 Pan troglodytes
2768674 Drosophila melanogaster
100024226 Monodelphis domestica
100051871 Equus caballus
100455970 Pongo abelii
100469116 Ailuropoda melanoleuca
100487938 Xenopus (Silurana) tropicalis
100546871 Meleagris gallopavo
100560437 Anolis carolinensis
394241 Danio rerio
415935 Gallus gallus
734196 Xenopus laevis
100346581 Oryctolagus cuniculus
100620065 Bombyx mori
2177 Homo sapiens
211651 Mus musculus
312641 Rattus norvegicus
484659 Canis lupus familiaris
100522343 Sus scrofa
515845 Bos taurus
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