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The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). Additionally we are shipping FANCD2 Antibodies (148) and and many more products for this protein.
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Wang, Wang, Qi: Identification of riboflavin: revealing different metabolic characteristics between Escherichia coli BL21(DE3) and MG1655. in FEMS microbiology letters 2015
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FANCD2 acts independently of previous S phases to promote alignment and segregation of acentric DNA produced by double-strand breaks.
Fancd2 has a role in DNA repair.
study showed that FANCI (show FANCI ELISA Kits)-FANCD2 is required for replication-coupled DNA interstrand cross-link (ICL) repair in S phase; results show that multiple steps of the essential S-phase ICL repair mechanism fail when the Fanconi anemia (show PALB2 ELISA Kits) pathway is compromised
The Fanconi anemia protein FANCM (show FANCM ELISA Kits) is controlled by FANCD2 and the ATR (show ATR ELISA Kits)/ATM (show ATM ELISA Kits) pathways.
silkworm cells deficient for FA proteins FancD2 and FancM (show FANCM ELISA Kits) exhibit normal sensitivities to hydroxyurea (HU) and camptothecin (CPT (show DHDDS ELISA Kits))
It was shown that silkworm FancD2 is monoubiquitinated depending on FancI (show FANCI ELISA Kits) and FancL (show FANCL ELISA Kits), and stabilized on chromatin, following mitomycin C. Depletion of FancD2, FancI (show FANCI ELISA Kits) or FancL (show FANCL ELISA Kits) effected cell proliferation in the presence of mitomycin C.
FANCD2 has a ubiquitination-independent role in countering endogenous levels of replication stress, a function that is critical for the maintenance of genomic stability.
Data suggest that FANCI (show FANCI ELISA Kits) and FANCD2 have partially non-overlapping and possibly even opposing roles during the replication stress response.
Fanconi anemia (show PALB2 ELISA Kits) FANCD2 and FANCI (show FANCI ELISA Kits) proteins regulate the nuclear dynamics of splicing factors, such as SF3B1.
People with Fanconi anemia (show PALB2 ELISA Kits), or healthy people who develop sporadic mutations in FANCD2, may be hypersensitive to the carcinogenic activity of coffee.
Results indicate the importance of DNA binding and nuclear localization sequences (NLS (show ALDH1A2 ELISA Kits)) residues in Fanconi Anemia Group D2 Protein (FANCD2) to activate an efficient Fanconi anemia (show PALB2 ELISA Kits) (FA) pathway.
FANCB (show BRCA2 ELISA Kits) dimer coordinates FANCD2:FANCI (show FANCI ELISA Kits) monoubiquitination by two FANCL (show FANCL ELISA Kits) RING-ligases. Deubiquitination of FANCD2:FANCI (show FANCI ELISA Kits) by USP1 (show USP1 ELISA Kits):UAF1 (show WDR48 ELISA Kits) occurs only when DNA is removed.
These results reveal a synthetic lethal relationship between FANCD2 and BRCA1/2.
these findings provide a previously unrecognized central player FANCD2-V2 and thus novel insights into human tumorigenesis, and indicate that V2/V1 can act as an effective biomarker in assisting the recognition of tumor malignance
The data demonstrate that FANCD2 protein is required to ensure efficient chromosome fragile sites (CFS) replication and provide mechanistic insight into how FANCD2 regulates CFS stability.
A breakdown in a BRCA/FANCD2/BRG1 (show SMARCA4 ELISA Kits)/SNF (show SNRPA ELISA Kits)-DeltaNP63-mediated DNA repair and differentiation maintenance process in mammary epithelial cells may contribute to sporadic breast cancer development.
Fancd2-/- mice exhibit a pervasive developmental HSPC defect that echoes the constitutional defects evident at birth in a subset of FA patients.
loss of Fancd2 yields significant defects to fetal liver hematopoiesis, particularly the HSC (show FUT1 ELISA Kits) population, which mimics key phenotypes from adult Fancd2 KO bone marrow independently of aging-accrued DNA damage.
Data that suggest Usp1 (ubiquitin specific peptidase 1 (show USP1 ELISA Kits)) down-regulation by autocleavage is critical for Usp1 (show USP1 ELISA Kits) to exert role in DNA interstrand crosslink repair; Usp1 (show USP1 ELISA Kits) role is de-ubiquitination of Fancd2 and Pcna (proliferating cell nuclear antigen (show PCNA ELISA Kits)).
recruitment of Fan1 (show FAN1 ELISA Kits) by ubiquitinated-Fancd2 is dispensable for DNA interstrand cross-links repair
Results show that FANCD2 and ADH5 (show ADH5 ELISA Kits) protect hematopoietic stem cells, hepatocytes, and nephrons from endogenous DNA damage resulting from accumulation of endogenous formaldehyde.
Combined deficiency of Foxo3a (show FOXO3 ELISA Kits) and Fancc (show FANCC ELISA Kits) or Fancd2 not only impairs the self-renewal capacity but also markedly increases the apoptosis of neural stem and progenitor cells (NSPCs), leading to defective neurogenesis.
Data demonstrated that Fancd2 was required for nuclear retention of CA-FOXO3a (show FOXO3 ELISA Kits) and for maintaining hematopoietic repopulation of the HSCs.
CD25 (show IL2RA ELISA Kits)(+)Foxp3 (show FOXP3 ELISA Kits)(+) Tregs of Fanca (show FANCA ELISA Kits)(-/-) or Fancd2(-/-) mice were less efficient in suppressing the production of GVHD-associated inflammatory cytokines.
Fancd2-Ub activates the transcription of the tumor suppressor TAp63, thereby promoting cellular senescence and blocking skin tumorigenesis.
Studies indicate that in Fancd2-Knockout mice, the formation of sex-cords and intraovarian tubules lead to the formation of tumours with multiple phenotypes including luteomas, papillary cysts and malignant carcinomas.
The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in two transcript variants encoding different isoforms.
Fanconi anemia, complementation group D2
, Fanconi anemia group D2 protein-like
, fanconi anemia protein FANCD2
, Fanconi anemia complementation group D2
, Fanconi anemia group D2 protein
, Fanconi anemia group D2 protein homolog
, Fanconi anemia D2 protein