anti-Fat Mass and Obesity-Associated (FTO) Antibodies

FTO is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of FTO is not known.

list all antibodies Gene Name GeneID UniProt
Anti-Human FTO FTO 79068 Q9C0B1
Anti-Mouse FTO FTO 26383 Q8BGW1
Anti-Rat FTO FTO 291905 Q2A121
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Top anti-FTO Antibodies at antibodies-online.com

Showing 10 out of 150 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-Fto Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Mouse Brain WB Suggested Anti-Fto Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  Mouse Brain 100 μL Log in to see 2 to 3 Days
$289.00
Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-FTO Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  PANC1 cell lysate WB Suggested Anti-FTO <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.2500 <br /> Positive Control: PANC1 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB Western blot analysis of FTO expression in HepG2 (A), Caco2 (B), SHSY5Y (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Goat Un-conjugated ELISA, WB ABIN308414 (0.03µg/ml) staining of Human Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 6 to 7 Days
$358.02
Details
Human Rabbit Un-conjugated FACS, IHC, WB 100 μL Log in to see 2 to 3 Days
$245.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of FTO Antibody (N-term) in NCI-H460 cell line lysates (35 µg/lane). FTO (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated WB Detection of FTO in human brain lysate using ABIN258809. 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Human Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Cow Rabbit Un-conjugated IHC, IHC (p), WB Human Small Intestine: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 7 to 9 Days
$727.83
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of FTO Antibody (N-term) (ABIN390964) in NCI-H460 cell line lysates (35 µg/lane). FTO (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with FTO Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details

Top referenced anti-FTO Antibodies

  1. Human Polyclonal FTO Primary Antibody for ELISA, WB - ABIN316349 : Gerken, Girard, Tung, Webby, Saudek, Hewitson, Yeo, McDonough, Cunliffe, McNeill, Galvanovskis, Rorsman, Robins, Prieur, Coll, Ma, Jovanovic, Farooqi, Sedgwick, Barroso, Lindahl, Ponting, Ashcroft et al.: The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. ... in Science (New York, N.Y.) 2007 (PubMed)

  2. Human Polyclonal FTO Primary Antibody for WB - ABIN258809 : Walters, Mercaldo, Gillon, Yip, Neve, Boyce, Frankland, Josselyn: The Role of The RNA Demethylase FTO (Fat Mass and Obesity-Associated) and mRNA Methylation in Hippocampal Memory Formation. in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2017 (PubMed)

More Antibodies against FTO Interaction Partners

Human Fat Mass and Obesity-Associated (FTO) interaction partners

  1. FTO rs9939609 is associated with obesity risk and LTL in this study, where this association is only observed at higher, but not lower, FTO methylation levels of participants. Our data suggest association of multiple factors, including FTO methylation level, may be involved in one of several mechanisms underlying the commonly reported obesity risk of this FTO polymorphism.

  2. This study indicates that FTO expression may have an important role in promoting the occurrence of gastric cancer (GC), and it may be an vital molecular marker in the diagnosis and prognosis of GC patients

  3. Mediterranean Diet adherence can be useful for prevention or treatment of obesity phenotypes in subjects with FTO risk alleles.

  4. FTO increased the lipid accumulation in hepatocytes by increasing nuclear translocation of SREBP1c (show SREBF1 Antibodies) and SREBP1c (show SREBF1 Antibodies) maturation, thus improving the transcriptional activity of lipid droplet-associated protein (show PLIN1 Antibodies) CIDEC (show CIDEC Antibodies).

  5. Two FTO variants, found in 14 affected individuals from three families, were also associated with leanness in these patients with Delayed Puberty. One variant (p.Leu44Val) demonstrated altered demethylation activity of the mutant protein in vitro. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty.

  6. The aggregation analysis revealed a higher correlation between siblings than between parent-offspring pairs representing the role of genetic factors in metabolic syndrome (MetS (show ETV3 Antibodies)). In addition, the conditional logistic model with covariates showed that the linkage results between HDL_C and three markers, FTO (rs1558902 and rs7202116) and CETP (show CETP Antibodies)(rs1864163) were significant.

  7. genetic association studies in population of adolescents in the United States: Data suggest that an SNP in FTO (rs9939609) is associated with adolescent overweight/obesity and obesogenic appetitive traits (decreased satiety responsiveness and increased food responsiveness) in the population studied.

  8. This meta-analysis provides additional support for a significant interaction between FTO, depression and BMI, indicating that depression increases the effect of FTO on BMI.

  9. children at risk for obesity possessing the obesity risk polymorphism (FTO rs9939609) exhibited stronger responses to food commercials in the nucleus accumbens (NAcc) than children not at risk. Similarly, children at a higher genetic risk for obesity possessing the obesity risk polymorphism (FTO rs9939609) demonstrated larger NAcc volumes.

  10. Variations within FTO may be predictors of fatty liver disease in HIV-infected patients independently of metabolic factors.

Mouse (Murine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well.

  2. FTO demethylase (show MBD2 Antibodies) activity is essential for normal bone development and mineralization, a previously unreported FTO function.

  3. FTO is critically involved in insulin (show INS Antibodies) defects-related Alzheimer's disease.

  4. This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK (show HNRNPK Antibodies) proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK (show HNRNPK Antibodies) in FTO-associated transformations.

  5. Contextual fear conditioning decreased FTO levels in neurons from the hippocampus.

  6. The involvement of mTOR (show FRAP1 Antibodies)-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed.

  7. In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice.

  8. propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases

  9. the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L (show RPGRIP1L Antibodies), and possibly other genes.

  10. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis

Pig (Porcine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. Studied role of FTO alpha-ketoglutarate dependent dioxygenase (FTO) in adipogenesis of intramuscular adipocytes.

  2. In this study, the authors characterise the nucleotide variability and haplotype diversity of the porcine fat mass and obesity-associated (FTO) gene in breeds having different predispositions to fat deposition traits.

  3. In pig, the FTO gene influences back fat depth in the commercial populations.

  4. This study will provide clues for obtaining a better understanding of the porcine FTO gene function.

  5. The results of the association analyses confirmed the effect of the FTO mutation on obesity-related traits in the Italian Duroc pigs (P < 0.01) and in the commercial pigs.

  6. The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs.

Cow (Bovine) Fat Mass and Obesity-Associated (FTO) interaction partners

  1. 34 FTO polymorphisms revealed significant association of FTO variants with lean meat percentage in Simmental and Brown cattle breeds.

  2. association signals not only provided evidence for at least two causative mutations in the FTO locus with a functional effect on milk but also milk protein (show CSN2 Antibodies) yield

  3. Haplotype frequencies and linkage disequilibrium (LD) coefficients of FTO single nucleotide polymorphisms in three Chinese indigenous cattle breeds were analyzed.

FTO Antigen Profile

Protein Summary

This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes.

Gene names and symbols associated with FTO

  • FTO, alpha-ketoglutarate dependent dioxygenase (FTO) antibody
  • fat mass and obesity associated (Fto) antibody
  • FTO, alpha-ketoglutarate dependent dioxygenase (Fto) antibody
  • fat mass and obesity associated L homeolog (fto.L) antibody
  • AW743446 antibody
  • mKIAA1752 antibody
  • RGD1305121 antibody

Protein level used designations for FTO

alpha-ketoglutarate-dependent dioxygenase FTO , fat mass and obesity-associated protein , protein fto , protein fatso , fat mass and obesity associated protein , Protein fatso

GENE ID SPECIES
79068 Homo sapiens
26383 Mus musculus
478125 Canis lupus familiaris
100127165 Sus scrofa
291905 Rattus norvegicus
100060565 Equus caballus
618622 Bos taurus
100125353 Ovis aries
447305 Xenopus laevis
100173222 Pongo abelii
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