Fc Receptor, IgG, Low Affinity IV Proteins

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578).

Type
  • 4
    Protein
Antigen
  • 4
Reactivity
  • 4
Application
  • 4
  • 3
  • 1
  • 1
  • 1
Host
  • 4
Binding Specificity
  • 3
  • 1
Conjugate
  • 2
  • 1
  • 1
Protein Type
  • 4
Format
  • 4
Biological Activity
  • 3
4 Products
Recombinant Protein, Human Cells (Source), Purity Greater than 95 % as determined by reducing SDS-PAGE.
ReactivityMouse (Murine)
Application ELISA, MS, SDS, WB
Order details Cat. No. ABIN5955402
$225.00
10 μg
Plus shipping costs $45.00
Delivery in 15 to 16 Business Days
Recombinant Protein, Human Cells (Source), Purity > 95 % as determined by SDS-PAGE
ReactivityMouse (Murine)
Application Func, SDS
Order details Cat. No. ABIN2007202
ISO
$440.65
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
Recombinant Protein, Human Cells (Source), Purity > 97 % as determined by SDS-PAGE
ReactivityMouse (Murine)
Application Func, SDS
Order details Cat. No. ABIN2007204
ISO
$440.65
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
Recombinant Protein, Human Cells (Source), Purity > 95 % as determined by SDS-PAGE
ReactivityMouse (Murine)
Application Func, SDS
Order details Cat. No. ABIN2007207
ISO
$440.65
Plus shipping costs $45.00
Delivery in 14 to 16 Business Days
  • <
  • 1
  • >

Fc Receptor, IgG, Low Affinity IV (FCGR4) Protein Profile

Protein Summary

Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:18097064, ECO:0000269|PubMed:18949059, ECO:0000269|PubMed:19795417, ECO:0000269|PubMed:25824719}.

Gene names and symbols associated with FCGR4

  • Fc receptor, IgG, low affinity IV (Fcgr4) antibody
  • 4833442P21Rik antibody
  • CD16-2 antibody
  • FcgammaRIV antibody
  • Fcgr3a antibody
  • FcgRIV antibody
  • Fcrl3 antibody

Protein level used designations for FCGR4

CD16-2 , Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16) , Fc gammaRIV , Fc receptor-like 3 , FcgammaRIV , low affinity immunoglobulin gamma Fc region receptor III-A , low affinity immunoglobulin gamma Fc region receptor IV

GENE ID SPECIES
246256 Mus musculus
Did you look for something else?