Fc Receptor, IgG, Low Affinity IV Products
(Fc Receptor, IgG, Low Affinity IV (FCGR4))
Categories
Receptor for the Fc region of immunoglobulin gamma (PubMed:16039578). Also acts as a receptor for the Fc region of immunoglobulin epsilon (PubMed:17558411, PubMed:18949059). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Mediates neutrophil activation by IgG complexes redundantly with Fcgr3 (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of proinflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:18097064, ECO:0000269|PubMed:18949059, ECO:0000269|PubMed:19795417, ECO:0000269|PubMed:25824719}.
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Featured Fc Receptor, IgG, Low Affinity IV Categories
Fc Receptor, IgG, Low Affinity IV Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Fc Receptor, IgG, Low Affinity IV ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6730047
Quantity
96 tests
Datasheet
Datasheet
Recommended Fc Receptor, IgG, Low Affinity IV Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Human Cells
Validations
Cat. No.
ABIN7314672
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Fc Receptor, IgG, Low Affinity IV products
: "Agonist anti-GITR monoclonal antibody and stereotactic radiation induce immune-mediated survival advantage in murine intracranial glioma." in: Journal for immunotherapy of cancer, Vol. 4, pp. 28, (2016) (PubMed).: "Interaction with Fc?RIIB is critical for the agonistic activity of anti-CD40 monoclonal antibody." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 187, Issue 4, pp. 1754-63, (2011) (PubMed).
Synonyms and alternative names related to Fc Receptor, IgG, Low Affinity IV
Fc receptor, IgG, low affinity IV (Fcgr4), 4833442P21Rik, CD16-2, FcgammaRIV, Fcgr3a, FcgRIV, Fcrl3Protein level used designations for Fc Receptor, IgG, Low Affinity IV
- CD16-2
- Fc fragment of IgG, low affinity IIIa, receptor for (CD16); Fc fragment of IgG, low affinity III, receptor for (CD16)
- Fc gammaRIV
- Fc receptor-like 3
- FcgammaRIV
- low affinity immunoglobulin gamma Fc region receptor III-A
- low affinity immunoglobulin gamma Fc region receptor IV
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