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FERMT1 encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. Additionally we are shipping FERMT1 Kits (6) and FERMT1 Proteins (5) and many more products for this protein.
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we demonstrated that Kindlin-1 promotes CRC (show CALR Antibodies) progression by recruiting SARA (show ZFYVE9 Antibodies) and Smad3 (show SMAD3 Antibodies) to TbetaRI (show TGFBR1 Antibodies) and thereby activates TGF-beta (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling. Thus, Kindlin-1 is a novel regulator of TGF-beta (show TGFB1 Antibodies)/Smad3 (show SMAD3 Antibodies) signaling and may also be a potential target for CRC (show CALR Antibodies) therapeutics.
Sequence analysis of KIND1 exons in patient 1 revealed a commonly reported homozygous nonsense mutation in exon 6 (c.811C>T;p.R271X). Both Patients 2 and 3 had novel homozygous single nucleotide deletions
these data define a novel role for Kin1 in microtubule acetylation and stability
keratinocytes derived from KS patients are unable to undergo electrotaxis, and this defect is restored by overexpression of wild-type kindlin-1 but not a W612A mutation that prevents kindlin-integrin binding.
FERMT1 activates the beta-catenin (show CTNNB1 Antibodies) transcriptional activity to promote EMT (show ITK Antibodies) in CC metastasis.
KIND1 is important not only for keratinocyte proliferation but also for the suppression of UV-induced inflammation and DNA damage.
We show a direct relationship between kindlin-1 abundance and UV-B induced apoptosis in keratinocytes, whereas kindlin-2 (show FERMT2 Antibodies) overexpression has no compensatory effect.
These results indicate that Kindlin-1 is essential in EGF (show EGF Antibodies)-induced re-epithelialization in skin wound healing and provide additional rationale for the clinical application of EGF (show EGF Antibodies) in the treatment of acute wounds.
KS is caused by mutations in the FERMT1 gene. Including the present, more than 60 mutations in FERMT1 have been identified since 2003. In spite of the expanding FERMT1 mutation database, there seems to be a lack of a clear genotype-phenotype correlation in KS
A nonsense mutation in Exon 5 of KIND1 Gene in an Iranian Family may lead to incomplete and non-functional protein products and is pathogenic and has meaningful implications for the diagnosis of patients with Kindler syndrome.
By modulating its affinity with kindlin, beta3 integrin (show ITGB3 Antibodies) may be able to locate near the cell edge where it can control beta1 integrin activation and clustering.
Kindlin-1 is highly expressed in epithelial tissues derived from ectoderm and endoderm. Kindlin-1 was also found highly expressed in endoderm/ectoderm-derived tissues in embryos.
Kindlin-1 controls keratinocyte adhesion through beta1-class integrins and proliferation and differentiation of cutaneous epithelial stem cells via TGF-beta (show TGFB1 Antibodies) activation and Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) signal inhibition.
Kindlin-1 and Kindlin-2 (show FERMT2 Antibodies) have opposite roles in lung cancers
Kindlin-1 in mice gives rise to skin atrophy and an intestinal epithelial dysfunction with similarities to human ulcerative colitis.
Kindlin-1 and -2 directly bind the C-terminal region of beta integrin cytoplasmic tails and exert integrin-specific activation effects
Kindlin1 knockdown resulted in developmental delays, gross malformations of the gut (show GUSB Antibodies) and eventual lethality by tadpole stages.
The rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo.
This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome.
UNC112 related protein 1
, fermitin family homolog 1
, kindlin 1
, kindlin syndrome protein
, unc-112-related protein 1
, UNC-112 related protein 1
, fermitin family member 1
, fermitin family homolog 1-like