FERMT1 antibody (AA 601-677)

Catalog No. ABIN6989195

The Rabbit Polyclonal anti-FERMT1 antibody is suitable to detect FERMT1 in samples from Human. It has been validated for IF (cc), IF (p), IHC (p) and IHC (fro).

Quick Overview for FERMT1 antibody (AA 601-677) (ABIN6989195)

Target: FERMT1 (Fermitin Family Member 1 (FERMT1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FERMT1 antibody is un-conjugated

Application: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-FERMT1 Antibody

Binding Specificity: AA 601-677

Purpose: Kindlin Polyclonal Antibody

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kindlin

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for FERMT1

Target: FERMT1 (Fermitin Family Member 1 (FERMT1))

Alternative Name: Kindlin

Background:

Synonyms: C20orf42, Chromosome 20 open reading frame 42, DTGCU 2, DTGCU2, FERM1_HUMAN, Fermitin family homolog 1, Fermt1, FLJ20116, FLJ23423, KIND 1, KIND1, Kinderlin, Kindlerin, Kindlin 1, Kindlin syndrome protein, Kindlin-1, Kindlin1, Unc 112 related protein 1, Unc-112-related protein 1, Unc112 related protein, UNC112A, URP 1, URP1.

Background: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression.

Gene ID: 55612

UniProt: Q9BQL6